Cell and Tissue Biology

, Volume 7, Issue 2, pp 149–153 | Cite as

Characteristics of capsaicin-sensitive afferent neurons of spinal nerve ganglia

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Abstract

Morphological peculiarities of neurons that had TRPV1, SP, CGRP, and NF200 markers in thoracic spinal ganglia nerves were studied in 3-month-old rats subjected to chemical deafferentation produced by capsaicin. The obtained results have shown that from 6.5 to 41.3% of ganglion neurons in the control group of animals contain, as a rule, one of the above-mentioned markers. The heterogeneity of nociceptive neurons observed in a control group of rats was also preserved in the capsaicin-treated animals. In both groups, the spinal ganglion TRPV1 neurons were predominant, whereas populations of SP, CGRP, and NF200 neurons formed smaller groups. In each population, sensitivity to capsaicin was shown in the largest neurons, regardless of marker; this sensitivity was pronounced to the greatest degree in the group of TRPV1 neurons.

Keywords

neuron spinal ganglion immunohistochemistry capsaicin rat 

Abbreviations

SGTN

sensitive of the second thoracic spinal nerve

CGRP

calcitonin gene-related peptide

NF200

protein of neurofilaments with mol. mass of 200 kDa

SP

substance P

TRPV1

TRPV1-receptors (transient receptor potential vanilloid receptor 1)

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Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  1. 1.Department of AnatomyState Medical Academy of Ministry of Health Service and Social DevelopmentYaroslavlRussia

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