Cell and Tissue Biology

, Volume 7, Issue 2, pp 149–153 | Cite as

Characteristics of capsaicin-sensitive afferent neurons of spinal nerve ganglia



Morphological peculiarities of neurons that had TRPV1, SP, CGRP, and NF200 markers in thoracic spinal ganglia nerves were studied in 3-month-old rats subjected to chemical deafferentation produced by capsaicin. The obtained results have shown that from 6.5 to 41.3% of ganglion neurons in the control group of animals contain, as a rule, one of the above-mentioned markers. The heterogeneity of nociceptive neurons observed in a control group of rats was also preserved in the capsaicin-treated animals. In both groups, the spinal ganglion TRPV1 neurons were predominant, whereas populations of SP, CGRP, and NF200 neurons formed smaller groups. In each population, sensitivity to capsaicin was shown in the largest neurons, regardless of marker; this sensitivity was pronounced to the greatest degree in the group of TRPV1 neurons.


neuron spinal ganglion immunohistochemistry capsaicin rat 



sensitive of the second thoracic spinal nerve


calcitonin gene-related peptide


protein of neurofilaments with mol. mass of 200 kDa


substance P


TRPV1-receptors (transient receptor potential vanilloid receptor 1)


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© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  1. 1.Department of AnatomyState Medical Academy of Ministry of Health Service and Social DevelopmentYaroslavlRussia

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