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Cell and Tissue Biology

, 2:93 | Cite as

Micronucleus and antitumor activities of two newly synthesized pyrimidine derivatives

  • A. K. Nersesyan
  • R. E. Muradyan
  • F. G. Arsenyan
  • G. G. Danagulyan
Article

Abstract

Micronucleus and antitumor activities of two newly synthesized iodides of pyrazolo[1,5a]pyrimidines were studied on mice. Both compounds were slightly toxic and had no antitumor activity in mice with Ehrlich ascites carcinoma; only one of them had low micronucleus activity. Both compounds substantially increase the micronucleus as well as the antitumor activities of cyclophosphamide.

Key words

pyrazolo[1,5a] pyrimidine iodides mice micronuclei Ehrlich ascitic carcinoma antitumor activity cyclophosphamide 

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • A. K. Nersesyan
    • 1
  • R. E. Muradyan
    • 2
  • F. G. Arsenyan
    • 2
  • G. G. Danagulyan
    • 3
  1. 1.National Center of OncologyYerevanArmenia
  2. 2.Institute of Fine Organic ChemistryYerevanArmenia
  3. 3.Institute of Organic ChemistryYerevanArmenia

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