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Exosome Drug Delivery through the Blood–Brain Barrier: Experimental Approaches and Potential Applications

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Abstract

This review discusses the current experimental data on targeted drug delivery through the blood–brain barrier (BBB). We focus on exosome drug delivery and examine the unique biological structure of exosomes, which allows them to pack, store, and deliver various molecules to the brain. Various approaches to modification and engineering of exosomes are reviewed with an analysis of experimental studies of exosome drug delivery through the BBB. The problems associated with potential clinical uses of exosomes and their possible solutions are discussed.

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Authors and Affiliations

  1. Solov’ev Scientific and Practical Psychoneurological Center, Moscow Department of Healthcare, Moscow, Russia

    T. A. Druzhkova & A. A. Yakovlev

  2. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    A. A. Yakovlev

  3. ul. Butlerova, 5a, Moscow, 117485, Russia

    A. A. Yakovlev

Authors
  1. T. A. Druzhkova
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  2. A. A. Yakovlev
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Correspondence to A. A. Yakovlev.

Additional information

Original Russian Text © T.A. Druzhkova, A.A. Yakovlev, 2018, published in Neirokhimiya, 2018, Vol. 35, No. 3, pp. 201–211.

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Druzhkova, T.A., Yakovlev, A.A. Exosome Drug Delivery through the Blood–Brain Barrier: Experimental Approaches and Potential Applications. Neurochem. J. 12, 195–204 (2018). https://doi.org/10.1134/S1819712418030030

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  • DOI: https://doi.org/10.1134/S1819712418030030

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