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Pathophysiology and Treatment of Peritumoral Brain Edema: Possible Effect of Lidocaine

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Abstract

Brain tumors account to a great mortality worldwide. Malignant tumors worsen patients’ prognosis due to peritumoral edema which is highly associated with a longer hospital stay and a higher incidence of sequelae. However, also non-malignant tumors develop severe complications. Among them, meningioma represents 53% of the cases. During tumor growth, damage to vascular endothelium increases inflammation; primary neoplastic lesions frequently show a high extent of edema. This is responsible for the associated morbidity and mortality in several pathologies but it is refractory to almost all treatments. The pathophysiological mechanism of this edema is not well understood, but may involve cerebral and vascular compression, as well as hydrodynamic changes. Edema complicates tumor exeresis affecting patients’ outcome so it is essential to achieve an early diagnosis and to perform better management strategies. Transurgical imaging studies are very useful for this purpose but they are not available in every institution. Other methods to detect edema involve direct observation by the surgeon and his/her perception on brain relaxation, although these are subjective measures. Edema treatment includes corticosteroids, mannitol and hypertonic saline but they may cause severe side effects. It should be noticed that many of the intracellular events that are involved in the genesis of brain edema are inhibited by lidocaine, this molecule is a tertiary amine that blocks sodium channels. It has a well described pharmacological profile. For these reasons, this article examines the mechanisms of peritumoral brain edema and their possible pharmacologic interventions with lidocaine.

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References

  1. Cancer IAfRo (2012). http://www.iarc.fr. Accessed March 29, 2016.

  2. Ostrom, Q.T., Gittleman, H., Liao, P., Rouse, C., Chen, Y., Dowling, J., Wolinsky, Y., Kruchko, C., and Barnholtz-Sloan, J., Neurooncology, 2014, vol. 16 (Suppl. 4), pp. iv1–iv63.

    Google Scholar 

  3. INEGI (2016). http://cuentame.inegi.org.mx/poblacion/ defunciones.aspx?tema=P. Accessed March 28, 2016.

  4. Jiménez-Marcial, M.E. and Velásquez-Pérez, L., Gac. Med. Mex., 2004, vol. 140, pp. 155–162.

    PubMed  Google Scholar 

  5. Alan, N., Seicean, A., Seicean, S., Neuhauser, D., Benzel, E.C., and Weil, R.J., J. Clin. Neurosci., 2015, vol. 22, no. 9, pp. 1413–1419.

    Article  CAS  PubMed  Google Scholar 

  6. Sherchan, P., Kim, C.H., and Zhang, J.H., Acta Neurochir., 2013, vol. 118, pp. 129–133.

    Google Scholar 

  7. Weil, R.J. and Oldfield, E.H., Cerebral edema, Youmans Neurological Surgery, 5 ed., Winn, H.R. and Youmans, J.R., Eds., Philadelphia: Saunders, 2004, pp. 162–168.

  8. Newton, H.B. and Ray-Chaudhury, A., Overview of Brain Tumor Epidemiology and Histopathology, Handbook of Brain Tumor Chemotherapy, 1st ed., Newton, H.B., Ed., Amsterdam: Elsevier, 2006, pp. 3–20.

  9. Papadopoulos, M.C., Saadoun, S., Binder, D.K., Manley, G.T., Krishna, S., and Verkman, A.S., Neuroscience, 2004, vol. 29, no. 4, pp. 1009–1018.

    Article  Google Scholar 

  10. Weingart, J.D. and Brem, H., Basic Principles of Cranial Surgery for Brain Tumors, Youmans Neurological Surgery, 5 ed., Winn, H.R., and Youmans, J.R., Eds., Philadelphia: Saunders, 2004, pp. 1261–1266.

  11. Abbott, N.J., J. Anat., 2002, vol. 200, no. 6, pp. 629–638.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Merrill, M.J. and Oldfield, E.H., J. Neurosurg., 2005, vol. 103, no. 5, pp. 853–868.

    Article  CAS  PubMed  Google Scholar 

  13. Stover, J.F., Morganti-Kosmann, M.C., Lenzlinger, P.M., Stocker, R., Kempski, O.S., and Kossmann, T., J. Neurotrauma, 1999, vol. 16, no. 2, pp. 135–142.

    Article  CAS  PubMed  Google Scholar 

  14. Chu, H., Xiang, J., Wu, P., Su, J., Ding, H., Tang, Y., and Dong Q., J. Neuroinflammation, 2014, vol. 11, p.184.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Lukic-Panin, V., Kamiya, T., Zhang, H., Hayashi, T., Tsuchiya, A., Sehara, Y., Deguchi, K., Yamashita, T., and Abe, K., Brain Res., 2007, vol. 1176, pp. 143–150.

    Article  CAS  PubMed  Google Scholar 

  16. Michael, D.B., Byers, D.M., and Irwin, L.N., J. Clin. Neurosci., 2005, vol. 12, no. 3, pp. 284–290.

    Article  CAS  PubMed  Google Scholar 

  17. Mohammadi, M.T., Shid-Moosavi, S.M., and Dehghani, G.A., Pathophysiology, 2012, vol. 19, no. 1, pp. 13–20.

    Article  CAS  PubMed  Google Scholar 

  18. Pérez-Neri, I., Bargés-Coll, J., Ramírez-Bermúdez, J., García-López, R., Ojeda-López, C., Méndez-Rosito, D., Ramírez-Abascal, M., Márquez-Flores, M.Á., Nente, F., Avendaño, J., Montes, S., Gómez-Amador, J.L., Moreno-Jiménez, S., Soto-Hernández, J.L., and Ríos, C., Arch. Neurocien, 2011, vol. 16 (Suppl. II), pp. 22–24.

    Google Scholar 

  19. Nag, S., Manias, J.L., and Stewart, D.J., Acta Neuropathol., 2009, vol. 118, no. 2, pp. 197–217.

    Article  PubMed  Google Scholar 

  20. Bundgaard, H. and Cold, G.E., Br. J. Neurosurg., 2000, vol. 14, no. 3, pp. 229–234.

    Article  CAS  PubMed  Google Scholar 

  21. Dubois, L.G., Campanati, L., Righy, C., D’Andrea-Meira, I., Spohr, T.C., Porto-Carreiro, I., Pereira, C.M., Balça-Silva, J., Kahn, S.A., DosSantos, M.F., de Oliveira, M.A., Ximenes-da-Silva, A., Lopes, M.C., Faveret, E., Gasparetto, E.L., and Moura-Neto, V., Front. Cell. Neurosci., 2014, vol. 8, p.418.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Kröll, S., El-Gindi, J., Thanabalasundaram, G., Panpumthong, P., Schrot, S., Hartmann, C., and Galla, H.J., Ann. NY Acad. Sci., 2009, vol. 1165, pp. 228–239.

    Article  PubMed  Google Scholar 

  23. Fathi, A.-R. and Roelcke, U., Curr. Neurol. Neurosci. Rep., 2013, vol. 13, no.4, p.337.

    Article  PubMed  Google Scholar 

  24. Hou, J., Kshettry, V.R., Selman, W.R., and Bambakidis, N.C., Neurosurg. Focus, 2013, vol. 35, no. 6, p. E2.

    Article  PubMed  Google Scholar 

  25. Bartek, J., Jr., Sjåvik, K., Förander, P., Solheim, O., Gulati, S., Weber, C., Ingebrigtsen, T., and Jakola, A.S., World Neurosurg., 2015, vol. 83, no. 5, pp. 673–678.

    Article  PubMed  Google Scholar 

  26. Tamiya, T., Ono, Y., Matsumoto, K., and Ohmoto, T., Neurosurgery, 2001, vol. 49, no. 5, pp. 1046–1052.

    CAS  PubMed  Google Scholar 

  27. Bruzzone, M.G., D’Incerti, L., Farina, L.L., Cuccarini, V., and Finocchiaro, G., Q. J. Nucl. Med. Mol. Imaging, 2012, vol. 56, no. 2, pp. 112–137.

    CAS  Google Scholar 

  28. Di Costanzo, A., Trojsi, F., Giannatempo, G.M., Vuolo, L., Popolizio, T., Catapano, D., Bonavita, S., d’Angelo, V.A., Tedeschi, G., and Scarabino, T., J. Exp. Clin. Cancer Res., 2006, vol. 25, no. 3, pp. 383–390.

    PubMed  Google Scholar 

  29. Wu, C.T., Chen, L.C., Kuo, C.P., Ju, D.T., Borel, C.O., Cherng, C.H., and Wong, C.S., Anesth. Analg., 2010, vol. 110, no. 3, pp. 903–907.

    Article  CAS  PubMed  Google Scholar 

  30. Quentin, C., Charbonneau, S., Moumdjian, R., Lallo, A., Bouthilier, A., Fournier-Gosselin, M.P., Bojanowski, M., Ruel, M., Sylvestre, M.P., and Girard, F., Anesth. Analg., 2013, vol. 116, no. 4, pp. 862–868.

    Article  CAS  PubMed  Google Scholar 

  31. Rasmussen, M., Bundgaard, H., and Cold, G.E., J. Neurosurg., 2004, vol. 101, no. 4, pp. 621–626.

    Article  PubMed  Google Scholar 

  32. Yachnis, A.T. and Rivera-Zengotita, M.L., Cerebral Edema, Neuropathology, Philadelphia: Saunders/Elsevier, 2014, pp. 2–3.

    Google Scholar 

  33. Sandercock, P.A. and Soane, T., Cochrane Database Syst. Rev., 2011, vol. 9, p. CD000064.

    Google Scholar 

  34. Bebawy, J.F., J. Neurosurg. Anesthesiol., 2012, vol. 24, no. 3, pp. 173–177.

    Article  PubMed  Google Scholar 

  35. Grände, P-O. and Romner, B., J. Neurosurg. Anesthesiol., 2012, vol. 24, no. 4, pp. 407–412.

    Article  PubMed  Google Scholar 

  36. Mendelow, A.D., Teasdale, G.M., Russell, T., Flood, J., Patterson, J., and Murray, G.D., J. Neurosurg., 1985, vol. 63, no. 1, pp. 43–48.

    Article  CAS  PubMed  Google Scholar 

  37. Bratton, S.L., Chestnut, R.M., Ghajar, J., McConnell Hammond, F.F., Harris, O.A., Hartl, R., Manley, G.T., Nemecek, A., Newell, D.W., Rosenthal, G., Schouten, J., Shutter, L., Timmons, S.D., Ullman, J.S., Videtta, W., Wilberger, J.E., and Wright, D.W., Brain Trauma Foundation, American Association of Neurological Surgeons, Congress of Neurological Surgeons, Joint Section on Neurotrauma and Critical Care, AANS/CNS, J. Neurotrauma, 2007, Suppl. 1, pp. S14–S20.

    Google Scholar 

  38. McManus, M.L. and Soriano, S.G., Anesthesiology, 1998, vol. 88, no. 6, pp. 1586–1591.

    Article  CAS  PubMed  Google Scholar 

  39. Fink, M.E., Continuum (Minneap. Minn.), 2012, vol. 18, no. 3, pp. 640–654.

    Google Scholar 

  40. Froelich, M., Ni, Q., Wess, C., Ougorets, I., and Härtl, R., Crit. Care Med., 2009, vol. 37, no. 4, pp. 1433–1441.

    Article  CAS  PubMed  Google Scholar 

  41. Prabhakar, H., Singh, G.P., Anand, V., and Kalaivani, M., Cochrane Database Syst. Rev., 2014, vol. 7, p. CD010026.

    Google Scholar 

  42. Hauger, R.L., Risbrough, V., Brauns, O., and Dautzenberg, F.M., CNS Neurol. Disord. Drug Targets, 2006, vol. 5, no. 4, pp. 453–479.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Rothstein, J.D., Patel, S., Regan, M.R., Haenggeli, C., Huang, Y.H., Bergles, D.E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D.S., Toan, S.V., Bruijn, L.I., Su, Z.Z., Gupta, P., and Fisher, P.B., Nature, 2005, vol. 433, no. 7021, pp. 73–77.

    Article  CAS  PubMed  Google Scholar 

  44. Becker, D.E. and Reed, K.L., Anesth. Prog., 2012, vol. 59, no. 2, pp. 90–103.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Farag, E., Ghobrial, M., Sessler, D.I., Dalton, J.E., Liu, J., Lee, J.H., Zaky, S., Benzel, E., Bingaman, W., and Kurz, A., Anesthesiology, 2013, vol. 119, no. 4, pp. 932–940.

    Article  CAS  PubMed  Google Scholar 

  46. Hollmann, M.W. and Durieux, M.E., Anesthesiology, 2000, vol. 93, no. 3, pp. 858–875.

    Article  CAS  PubMed  Google Scholar 

  47. Liu, K., Adachi, N., Yanase, H., Kataoka, K., and Arai, T., Anesthesiology, 1997, vol. 87, no. 6, pp. 1470–1478.

    Article  CAS  PubMed  Google Scholar 

  48. Chen, J., Adachi, N., Liu, K., Nagaro, T., and Arai, T., Brain Res., 1998, vol. 792, no. 1, pp. 16–23.

    Article  CAS  PubMed  Google Scholar 

  49. Schurr, A., Spears, B., Reid, K.H., West, C.A., Edmonds, H.L., and Rigor, B.M., Anesthesiology, 1986, vol. 64, no. 4, pp. 501–503.

    Article  CAS  PubMed  Google Scholar 

  50. Fujitani, T., Adachi, N., Miyazaki, H., Liu, K., Nakamura, Y., Kataoka, K., and Arai, T., Neurosci. Lett., 1994, vol. 179, nos. 1–2, pp. 91–94.

    Article  CAS  PubMed  Google Scholar 

  51. Das, K.C. and Misra, H.P., Mol. Cell. Biochem., 1992, vol. 115, no. 2, pp. 179–185.

    Article  CAS  PubMed  Google Scholar 

  52. Astrup, J., Sørensen, P.M., and Sørensen, H.R., Anesthesiology, 1981, vol. 55, no. 3, pp. 263–268.

    Article  CAS  PubMed  Google Scholar 

  53. Lei, B., Popp, S., Capuano-Waters, C., Cottrell, J.E., and Kass, I.S., Neuroscience, 2004, vol. 125, no. 3, pp. 691–701.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neuroanesthesiology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico

    Luisa Piedad Manrique-Carmona

  2. Department of Neurochemistry, National Institute of Neurology and Neurosurgery, Mexico City, Mexico

    Iván Pérez-Neri

  3. Department of Neurochemistry, National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877, La Fama, Tlalpan, Mexico City, 14269, Mexico

    Iván Pérez-Neri

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  1. Luisa Piedad Manrique-Carmona
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Correspondence to Iván Pérez-Neri.

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Manrique-Carmona, L.P., Pérez-Neri, I. Pathophysiology and Treatment of Peritumoral Brain Edema: Possible Effect of Lidocaine. Neurochem. J. 12, 9–14 (2018). https://doi.org/10.1134/S1819712418010099

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