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Neurochemical Journal

, Volume 9, Issue 4, pp 271–274 | Cite as

The effects of glucocorticoids on the ratio between brain-derived neurotrophic factor and its proform in the neonatal hippocampus

  • A. V. Bannova
  • P. N. Men’shanov
  • N. N. Dygalo
Experimental Articles
  • 55 Downloads

Abstract

Hydrocortisone, which activates both mineralo- and glucocorticoid receptors, decreased the levels of the proform of the brain-derived neurotrophic factor (proBDNF), which induces apoptosis, and mature BDNF (mBDNF), which promotes the survival of brain cells, in the hippocampus of 8-day-old rats 6 h after drug administration. A shift in the mBDNF/proBDNF ratio to the prevalence of the antiapoptotic form of neurotrophin in the hippocampus after hormone treatment corresponded to a decrease in the content of the key executive apoptotic protease, active caspase-3. In contrast to hydrocortisone, dexamethasone, a selective agonist of glucocorticoid receptors, did not induce any alterations in the expression of the studied proteins. Thus, hydrocortisone in vivo had an antiapoptotic effect on the expression of both forms of BDNF in the hippocampus of neonatal rats.

Keywords

hippocampus hydrocortisone dexamethasone mBDNF proBDNF active caspase-3 

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References

  1. 1.
    Cohen-Cory, S., Kidane, A.H., Shirkey, N.J., and Marshak, S., Dev. Neurobiol., 2010, vol. 70, pp. 271–288.PubMedCentralPubMedGoogle Scholar
  2. 2.
    Bernd, P., Gene Expr., 2008, vol. 14, pp. 241–250.CrossRefPubMedGoogle Scholar
  3. 3.
    Barnes, P. and Thomas, K.L., PLoS ONE, 2008, vol. 3, e3248.PubMedCentralCrossRefPubMedGoogle Scholar
  4. 4.
    Muzyka, V.V., Men’shanov, P.N., Bannova, A.V., and Dygalo, N.N., Neurochem. J., 2012, vol. 6, pp. 260–264.CrossRefGoogle Scholar
  5. 5.
    Menshanov, P.N., Lanshakov, D.A., and Dygalo, N.N., Physiol. Res., vol. 64, pp. 801–810.Google Scholar
  6. 6.
    Liston, C. and Gan, W.B., Proc. Natl. Acad. Sci. USA, 2011, vol. 108, pp. 16074–16079.PubMedCentralCrossRefPubMedGoogle Scholar
  7. 7.
    Duman, R.S. and Monteggia, L.M., Biol. Psychiatry, 2006, vol. 59, pp. 1116–1127.CrossRefPubMedGoogle Scholar
  8. 8.
    Schaaf, M.J., de Jong, J., de Kloet, E.R., and Vreugdenhil, E., Brain Res., 1998, vol. 813, pp. 112–120.CrossRefPubMedGoogle Scholar
  9. 9.
    Bulygina, V.V., Shishkina, G.T., Berezova, I.V., and Dygalo, N.N., Dokl. Biol. Sci., 2011, vol. 437, pp. 82–84.CrossRefPubMedGoogle Scholar
  10. 10.
    Shi, S.S., Shao, S.H., Yuan, B.P., Pan, F., and Li, Z.L., Yonsei. Med. J., 2010, vol. 51, pp. 661–671.PubMedCentralCrossRefPubMedGoogle Scholar
  11. 11.
    McMillan, T.M. and Herbert, C.M., Brain Inj., 2004, vol. 18, pp. 935–940.CrossRefPubMedGoogle Scholar
  12. 12.
    de Kloet, E.R., Joels, M., and Holsboer, F., Nat. Rev. Neurosci., 2005, vol. 6, pp. 463–475.CrossRefPubMedGoogle Scholar
  13. 13.
    Menshanov, P.N., Bannova, A.V., and Dygalo, N.N., Neurochem. Res., 2006, vol. 31, pp. 869–875.CrossRefPubMedGoogle Scholar
  14. 14.
    Men’shanov, P.N., Muzyka, V.V., and Dygalo, N.N., Neurochem. J., 2011, vol. 5, pp. 20–23.CrossRefGoogle Scholar
  15. 15.
    Benders, M.J., Groenendaal, F., van Bel, F., Ha, VinhR., Dubois, J., Lazeyras, F., Warfield, S.K., Hüppi, P.S., and de Vries, L.S., Pediatr. Res., 2009, vol. 66, pp. 555–559.PubMedCentralCrossRefPubMedGoogle Scholar
  16. 16.
    Ichinohashi, Y., Sato, Y., Saito, A., Ito, M., Watanabe, K., Hayakawa, M., Nakanishi, K., Wakatsuki, A., and Oohira, A., Early Hum. Dev., 2013, vol. 89, pp. 283–288.CrossRefPubMedGoogle Scholar
  17. 17.
    Feng, Y., Lu, S., Wang, J., Kumar, P., Zhang, L., and Bhatt, A.J., Brain Res., 2014, vol. 1589, pp. 68–77.CrossRefGoogle Scholar
  18. 18.
    Chao, H.M., Sakai, R.R., Ma, L.Y., and McEwen, B.S., Endocrinology, 1998, vol. 139, pp. 3112–3118.CrossRefPubMedGoogle Scholar
  19. 19.
    Hansson, A.C., Sommer, W.H., Metsis, M., Stromberg, I., Agnati, L.F., and Fuxe, K., J. Neuroendocrinol., 2006, vol. 18, pp. 104–114.CrossRefPubMedGoogle Scholar
  20. 20.
    Hossain, A., Hajman, K., Charitidi, K., Erhardt, S., Zimmermann, U., Knipper, M., and Canlon, B., Endocrinology, 2008, vol. 149, pp. 6356–6365.CrossRefPubMedGoogle Scholar
  21. 21.
    Lessmann, V. and Brigadski, T., Neurosci. Res., 2009, vol. 65, pp. 11–22.CrossRefPubMedGoogle Scholar
  22. 22.
    Menshanov, P.N., Bannova, A.V., Bulygina, V.V., and Dygalo, N.N., Physiol. Res., 2013, vol. 62, pp. 205–213.PubMedGoogle Scholar
  23. 23.
    de Kloet, E.R., Fitzsimons, C.P., Datson, N.A., Meijer, O.C., and Vreugdenhil, E., Brain Res., 2009, vol. 1293, pp. 129–141.CrossRefPubMedGoogle Scholar
  24. 24.
    Menshanov, P.N., Bannova, A.V., and Dygalo, N.N., Behav. Brain Res., 2014, vol. 271, pp. 43–50.CrossRefPubMedGoogle Scholar
  25. 25.
    Almeida, O.F., Conde, G.L., Crochemore, C., Demeneix, B.A., Fischer, D., Hassan, A.H., Meyer, M., Holsboer, F., and Michaelidis, T.M., FASEB J., 2000, vol. 14, pp. 779–790.PubMedGoogle Scholar
  26. 26.
    Crochemore, C., Lu, J., Wu, Y., Liposits, Z., Sousa, N., Holsboer, F., and Almeida, O.F., Mol. Psychiatry, 2005, vol. 10, pp. 790–798.CrossRefPubMedGoogle Scholar
  27. 27.
    Gould, E., Tanapat, P., McEwen, B.S., Flugge, G., and Fuchs, E., Proc. Natl. Acad. Sci. USA, 1998, vol. 95, pp. 3168–3171.PubMedCentralCrossRefPubMedGoogle Scholar
  28. 28.
    Hassan, A.H.S., von Rosenstiel, P., Patchev, V.K., Holsboer, F., and Almeida, O.F.X., Exp. Neurol., 1996, vol. 140, pp. 43–54.CrossRefPubMedGoogle Scholar
  29. 29.
    McEwen, B.S., Annu. Rev. Neurosci., 1999, vol. 22, pp. 105–122.CrossRefPubMedGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • A. V. Bannova
    • 1
  • P. N. Men’shanov
    • 1
    • 2
  • N. N. Dygalo
    • 1
    • 2
  1. 1.Institute of Cytology and Genetics, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  2. 2.Novosibirsk State UniversityNovosibirskRussia

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