Skip to main content
SpringerLink
Log in

Neurogenesis and neuroinflammation: The role of Wnt proteins

  • Review Articles
  • Published:
Neurochemical Journal Aims and scope Submit manuscript

Abstract

Adult neurogenesis is an intensively studied phenomenon that is presumably involved in brain functioning under normal and some pathological conditions. Neuroinflammation as a non-specific response of the nerve tissue to pathologic conditions may change the course of adult neurogenesis in the brain and thus enable long-term functional and structural alterations. In this short review, we discuss the interaction of adult neurogenesis and neuroinflammation with a special emphasis on the place that is occupied in both these processes by morphogenic proteins of the Wnt family, which play an important role in the development of the nervous system, as well as in the neuroplasticity of the adult brain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

DG:

dentate gyrus

SGZ:

subgranular zone

GFAP:

glial fibrillary acidic protein

GSK:

3β, glycogen synthase kinase 3β

BMP:

bone morphogenic protein

IGF-1:

insulin-like growth factor 1

TNFα:

tumor necrosis factor α

IFNγ:

interferonγ

References

  1. Abrous, D.N., Koehl, M., and Le Moal, M., Physiol. Rev., 2005, vol. 85, no. 2, pp. 523–569.

    Article  CAS  PubMed  Google Scholar 

  2. Cameron, H.A., Woolley, C.S., McEwen, B.S., and Gould, E., Neuroscience, 1993, vol. 56, no. 2, pp. 337–344.

    Article  CAS  PubMed  Google Scholar 

  3. Encinas, J.M., Michurina, T.V., Peunova, N., Park, J.H., Tordo, J., Peterson, D.A., Fishell, G., Koulakov, A., and Enikolopov, G., Cell Stem Cell, 2011, vol. 8, no. 5, pp. 566–579.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Von Bohlen O. und Halbach, O., Cell Tissue Res., 2007, vol. 329, no. 3, pp. 409–420.

    Article  Google Scholar 

  5. Gage, F.H., Science, 2000, vol. 287, no. 5457, pp. 1433–1438.

    Article  CAS  PubMed  Google Scholar 

  6. Ma, D.K., Kim, W.R., Ming, G.L., and Song, H., Ann. New York Acad. Sci., 2009, vol. 1170, pp. 664–673.

    Article  Google Scholar 

  7. Bengzon, J., Kokaia, Z., Elmer, E., Nanobashvili, A., Kokaia, M., and Lindvall, O., Proc. Natl. Acad. Sci. USA, 1997, vol. 94, no. 19, pp. 10432–10437.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Rola, R., Mizumatsu, S., Otsuka, S., Morhardt, D.R., Noble-Haeusslein, L.J., Fishman, K., Potts, M.B., and Fike, J.R., Exp. Neurol., 2006, vol. 202, no. 1, pp. 189–199.

    Article  CAS  PubMed  Google Scholar 

  9. Nygren, J., Wieloch, T., Pesic, J., Brundin, P., and Deierborg, T., Stroke, 2006, vol. 37, no. 11, pp. 2824–2829.

    Article  PubMed  Google Scholar 

  10. Tonchev, A.B., Yamashima, T., and Chaldakov, G.N., Adv. Anat. Embryol. Cell Biol., 2007, vol. 191, pp. 1–106.

    Article  CAS  PubMed  Google Scholar 

  11. Parent, J.M., Valentin, V.V., and Lowenstein, D.H., J. Neurosci., 2002, vol. 22, no. 8, pp. 3174–3188.

    CAS  PubMed  Google Scholar 

  12. Scharfman, H.E., Neuroscientist, 2002, vol. 8, no. 2, pp. 154–173.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kitabatake, Y., Sailor, K.A., Ming, G.L., and Song, H., Neurosurg. Clin. N. Am., 2007, vol. 18, no. 1, pp. 105–113.

    Article  PubMed  Google Scholar 

  14. Deng, W., Aimone, J.B., and Gage, F.H., Nat. Rev. Neurosci., 2010, vol. 11, pp. 339–350.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Kempermann, G., Kuhn, H.G., and Gage, F.H., Nature, 1997, vol. 386, pp. 493–195.

    Article  CAS  PubMed  Google Scholar 

  16. Van Praag, H., Christie, B.R., Sejnowski, T.J., and Gage, F.H., Proc. Natl. Acad. Sci. USA, 1999, vol. 96, no. 23, pp. 13427–13431.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Van Praag, H., Kempermann, G., and Gage, F.H., Nat. Neurosci., 1999, vol. 2, no. 3, pp. 266–270.

    Article  PubMed  Google Scholar 

  18. Winocur, G., Wojtowicz, J.M., Sekeres, M., Snyder, J.S., and Wang, S., Hippocampus, 2006, vol. 16, no. 3, pp. 296–304.

    Article  PubMed  Google Scholar 

  19. Van der Borght, K., Meerlo, P., Luiten, P.G., Eggen, B.J., and Van der Zee, E.A., Behav. Brain Res., 2005, vol. 157, no. 1, pp. 23–30.

    Article  PubMed  Google Scholar 

  20. Saxe, M.D., Malleret, G., Vronskaya, S., Mendez, I., Garcia, A.D., Sofroniew, M.V., Kandel, E.R., and Hen, R., Proc. Natl. Acad. Sci. USA, 2007, vol. 104, no. 11, pp. 4642–4646.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Bonaguidi, M.A., Peng, C.Y., McGuire, T., Falciglia, G., Gobeske, K.T., Czeisler, C., and Kessler, J.A., J. Neurosci., 2008, vol. 28, no. 37, pp. 9194–9204.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Lie, D.C., Colamarino, S.A., Song, H.J., Desire, L., Mira, H., Consiglio, A., Lein, E.S., Jessberger, S., Lansford, H., Dearie, A.R., and Gage, F.H., Nature, 2005, vol. 437, no. 7063, pp. 1370–1375.

    Article  CAS  PubMed  Google Scholar 

  23. Li, F., Chong, Z.Z., and Maiese, K., Histol. Histopathol., 2006, vol. 21, no. 1, pp. 103–124.

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Katoh, M. and Katoh, M., Int. J. Mol. Med., 2005, vol. 15, no. 4, pp. 749–753.

    CAS  PubMed  Google Scholar 

  25. Li, F., Chong, Z.Z., and Maiese, K., Curr. Neurovasc. Res., 2005, vol. 2, no. 4, pp. 331–340.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Tamai, K. and He, X., Dev. Cell, 2009, vol. 17, no. 1, pp. 9–26.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Gaulden, J. and Reiter, J.F., Hum. Mol. Genet., 2008, vol. 17, no. R1, pp. R60–R66.

    Article  CAS  PubMed  Google Scholar 

  28. Nojima, H., Shimizu, T., Kim, C.H., Yabe, T., Bae, Y.K., Muraoka, O., Hirata, T., Chitnis, A., Hirano, T., and Hibi, M., Mech. Dev., 2004, vol. 121, pp. 371–386.

    Article  CAS  PubMed  Google Scholar 

  29. Wessely, O., Agius, E., Oelgeschlager, M., Pera, E.M., and De Robertis, E.M., Dev. Biol., 2001, vol. 234, pp. 161–173.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Yoshikawa, Y., Fujimori, T., McMahon, A.P., and Takada, S., Dev. Biol., 1997, vol. 183, pp. 234–242.

    Article  CAS  PubMed  Google Scholar 

  31. Kelly, O.G., Pinson, K.I., and Skarnes, W.C., Development, 2004, vol. 131, pp. 2803–2815.

    Article  CAS  PubMed  Google Scholar 

  32. Mukhopadhyay, M., Shtrom, S., Rodriguez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D.W., Glinka, A., Grinberg, A., Huang, S.P., Niehrs, C., Izpisua Belmonte, J.C., and Westphal, H., Dev. Cell, 2001, vol. 1, pp. 423–434.

    Article  CAS  PubMed  Google Scholar 

  33. De Robertis, E.M. and Kuroda, H., Annu. Rev. Cell Dev. Biol., 2004, vol. 20, pp. 285–308.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Jessberger, S., Clark, R.E., Broadbent, N.J., Clemenson, G.D., Consiglio, A., Lie, D.C., Squire, L.R., and Gage, F.H., Learn. Mem., 2009, vol. 16, no. 2, pp. 147–154.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Marchetti, B. and Pluchino, S., Trends Mol. Med., 2013, vol. 19, no. 3, pp. 144–156.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Sierra, A., Encinas, J.M., Deudero, J.J., Chancey, J.H., Enikolopov, G., Overstreet-Wadiche, L.S., Tsirka, S.E., and Maletic-Savatic, M., Cell Stem Cell, 2010, vol. 7, no. 4, pp. 483–495.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Ekdahl, C.T., Claasen, J.H., Bonde, S., Kokaia, Z., and Lindvall, O., Proc. Natl. Acad. Sci. USA, 2003, vol. 100, pp. 13632–13637.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Ziv, Y. and Schwartz, M., Brain Behav. Immun., 2008, vol. 22, pp. 167–176.

    Article  CAS  PubMed  Google Scholar 

  39. Aarum, J., Sandberg, K., Haeberlein, S.L., and Persson, M.A., Proc. Natl. Acad. Sci. USA, 2003, vol. 100, pp. 15983–15988.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Walton, N.M., Sutter, B.M., Laywell, E.D., Levkoff, L.H., Kearns, S.M., Marshall, G.P., Scheffler, B., and Steindler, D.A., Glia, 2006, vol. 54, pp. 815–825.

    Article  PubMed  Google Scholar 

  41. Vukovic, J., Colditz, M.J., Blackmore, D.G., Ruitenberg, M.J., and Bartlett, P.F., J. Neurosci., 2012, vol. 32, no. 19, pp. 6435–6443.

    Article  CAS  PubMed  Google Scholar 

  42. Gemma, C. and Bachstetter, A.D., Front. Cell Neurosci., 2013, vol. 7, p. 229.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Choi, S.H., Veeraraghavalu, K., Lazarov, O., Marler, S., Ransohoff, R.M., Ramirez, J.M., and Sisodia, S.S., Neuron, 2008, vol. 59, no. 4, pp. 568–580.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Gebara, E., Sultan, S., Kocher-Braissant, J., and Toni, N., Front. Neurosci., 2013, vol. 7, p. 145.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Ziv, Y., Ron, N., Butovsky, O., Landa, G., Sudai, E., Greenberg, N., Cohen, H., Kipnis, J., and Schwartz, M., Nat. Neurosci., 2006, vol. 9, pp. 268–275.

    Article  CAS  PubMed  Google Scholar 

  46. Ekdahl, C.T., Kokaia, Z., and Lindvall, O., Neuroscience, 2009, vol. 158, pp. 1021–1029.

    Article  CAS  PubMed  Google Scholar 

  47. Ben-Hur, T., Ben-Menachem, O., Furer, V., Einstein, O., Mizrachi-Kol, R., and Grigoriadis, N., Mol. Cell. Neurosci., 2003, vol. 24, pp. 623–631.

    Article  CAS  PubMed  Google Scholar 

  48. Cacci, E., Ajmone-Cat, M.A., Anelli, T., Biagioni, S., and Minghetti, L., Glia, 2008, vol. 56, pp. 412–425.

    Article  PubMed  Google Scholar 

  49. Iosif, R.E., Ekdahl, C.T., Ahlenius, H., Pronk, C.J., Bonde, S., Kokaia, Z., Jacobsen, S.E., and Lindvall, O., J. Neurosci., 2006, vol. 26, pp. 9703–9712.

    Article  CAS  PubMed  Google Scholar 

  50. Koo, J.W. and Duman, R.S., Proc. Natl. Acad. Sci. USA, 2008, vol. 105, pp. 751–756.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Monje, M.L., Toda, H., and Palmer, T.D., Science, 2003, vol. 302, pp. 1760–1765.

    Article  CAS  PubMed  Google Scholar 

  52. Cacci, E., Claasen, J.H., and Kokaia, Z., J. Neurosci. Res., 2005, vol. 80, pp. 789–797.

    Article  CAS  PubMed  Google Scholar 

  53. Jakubs, K., Bonde, S., Iosif, R.E., Ekdahl, C.T., Kokaia, Z., Kokaia, M., and Lindvall, O., J. Neurosci., 2008, vol. 28, no. 47, pp. 12477–12488.

    Article  CAS  PubMed  Google Scholar 

  54. Vallieres, L., Campbell, I.L., Gage, F.H., and Sawchenko, P.E., J. Neurosci., 2002, vol. 22, pp. 486–492.

    CAS  PubMed  Google Scholar 

  55. Parent, J.M., Prog. Brain Res., 2007, vol. 163, pp. 529–540.

    Article  CAS  PubMed  Google Scholar 

  56. Bonde, S., Ekdahl, C.T., and Lindvall, O., Eur. J. Neurosci., 2006, vol. 23, pp. 965–974.

    Article  PubMed  Google Scholar 

  57. Ivanova-Dyatlova, A.Yu., Aniol, V.A., and Gulyaeva, N.V., Neurochem. J., 2015, vol. 9, no. 3, pp. 232–236.

    Article  CAS  Google Scholar 

  58. Choi, Y.S., Cho, H.Y., Hoyt, K.R., Naegele, J.R., and Obrietan, K., Glia, 2008, vol. 56, pp. 791–800.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Kiyota, T., Okuyama, S., Swan, R.J., Jacobsen, M.T., Gendelman, H.E., and Ikezu, T., FASEB J., 2010, vol. 24, pp. 3093–3102.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Kiyota, T., Ingraham, K.L., Swan, R.J., Jacobsen, M.T., Andrews, S.J., and Ikezu, T., Gene Ther., 2012, vol. 19, pp. 724–733.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Mathieu, P., Piantanida, A.P., and Pitossi, F., Neuroimmunomodulation, 2010, vol. 17, pp. 200–201.

    Article  CAS  PubMed  Google Scholar 

  62. Annenkov, A., Mol. Neurobiol., 2009, vol. 40, pp. 195–215.

    Article  CAS  PubMed  Google Scholar 

  63. L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M.C., Cossetti, C., D’Adamo, P., Zardini, E., Andreoni, L., Ihekwaba, A.E., Serra, P.A., Franciotta, D., Martino, G., Pluchino, S., and Marchetti, B., Neurobiol. Dis., 2011, vol. 41, no. 2, pp. 508–527.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Halleskog, C., Mulder, J., Dahlstrom, J., Mackie, K., Hortobagyi, T., Tanila, H., Kumar, PuliL., Farber, K., Harkany, T., and Schulte, G., Glia, 2011, vol. 59, no. 1, pp. 119–131.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Halleskog, C., Dijksterhuis, J.P., Kilander, M.B., Becerril-Ortega, J., Villaescusa, J.C., Lindgren, E., Arenas, E., and Schulte, G., J. Neuroinflammation, 2012, vol. 9, p. 111.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Li, B., Zhong, L., Yang, X., Andersson, T., Huang, M., and Tang, S.J., PLoS One, 2011, vol. 6, no. 8, p. e22920.

    Article  Google Scholar 

  67. L’Episcopo, F., Serapide, M.F., Tirolo, C., Testa, N., Caniglia, S., Morale, M.C., Pluchino, S., and Marchetti, B., Mol. Neurodegener., 2011, vol. 6, p. 49.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    V. A. Aniol, A. O. Tishkina & N. V. Gulyaeva

Authors
  1. V. A. Aniol
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. O. Tishkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. V. Gulyaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. A. Aniol.

Additional information

Original Russian Text © V.A. Aniol, A.O. Tishkina, N.V. Gulyaeva, 2016, published in Neirokhimiya, 2016, Vol. 33, No. 1, pp. 5–11.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aniol, V.A., Tishkina, A.O. & Gulyaeva, N.V. Neurogenesis and neuroinflammation: The role of Wnt proteins. Neurochem. J. 10, 1–6 (2016). https://doi.org/10.1134/S1819712415040030

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1819712415040030

Keywords

Search

Navigation