Neurochemical Journal

, Volume 8, Issue 3, pp 205–207 | Cite as

Pinealon corrects hyperhomocysteinemia-induced disturbances of the diurnal dynamics of hypothalamic norepinephrine content in female rats

  • A. V. Korenevskii
  • A. V. Arutyunyan
  • Yu. P. Milyutina
  • I. V. Zaloznyaya
  • L. S. Kozina
Experimental Articles


The effect of experimental hyperhomocysteinemia on diurnal dynamics of norepinephrine content in the medial preoptic area of the female rat hypothalamus, which is responsible for the synthesis of gonadotropin-releasing hormone (GnRH), has been studied. We investigated plausible neuroprotective effects of the pineal gland peptide pinealon (Glu-Asp-Arg). It has been found that administration of the substance can correct the deficiencies in the normal diurnal dynamics of norepinephrine content in the studied hypothalamic area that were caused by L-methionine loading. The data we obtained testify to the protective effect of pinealon and to its ability to diminish the unfavorable effect of hyperhomocysteinemia on the female rat reproductive function.


reproduction hypothalamus diurnal rhythms norepinephrine melatonin pinealon gonadotropin-releasing hormone (GnRH) 


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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • A. V. Korenevskii
    • 1
  • A. V. Arutyunyan
    • 1
    • 3
  • Yu. P. Milyutina
    • 1
  • I. V. Zaloznyaya
    • 1
  • L. S. Kozina
    • 2
  1. 1.Ott Research Institute of Obstetrics and GynecologyRussian Academy of Medical SciencesSt. PetersburgRussia
  2. 2.St. Petersburg Institute of Bioregulation and GerontologySt. PetersburgRussia
  3. 3.St. PetersburgRussia

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