Neurochemical Journal

, Volume 8, Issue 1, pp 24–27 | Cite as

The thiol-disulfide balance and the nitric oxide system in the brain tissue of rats subjected to experimental acute impairment of cerebral blood flow: The therapeutic effects of nootropic drugs

  • I. F. Belenichev
  • S. V. Gorbacheva
  • A. V. Demchenko
  • N. V. Bukhtiyarova
Experimental Articles

Abstract

Modeling of the acute impairment of cerebral blood flow was associated with disturbance of the thiol-disulfide balance, a decrease in NO-synthase activity, and an increase in the nitrotyrosine content, indicating the development of oxidative and nitrosative stress in brain tissue. Administration of thiotriazoline or α-lipoic acid resulted in the optimal ratio between the levels of reduced and oxidized thiol groups and glutathione, which demonstrates the active involvement of the thiol-disulfide system in the neutralization of products of free-radical oxidation. The effects of thiotriazoline or α-lipoic acid were related to the presence of thiol groups in their structures. Due to this, these drugs are able to normalize the glutathione system under conditions of oxidative stress.

Keywords

acute impairment of cerebral blood flow thiol-disulfide balance thiotriazoline α-lipoic acid glutathione system 

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • I. F. Belenichev
    • 1
  • S. V. Gorbacheva
    • 1
    • 2
  • A. V. Demchenko
    • 1
  • N. V. Bukhtiyarova
    • 1
  1. 1.Zaporozhye State Medical UniversityZaporozhyeUkraine
  2. 2.ZaporozhyeUkraine

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