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The thiol-disulfide balance and the nitric oxide system in the brain tissue of rats subjected to experimental acute impairment of cerebral blood flow: The therapeutic effects of nootropic drugs

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Abstract

Modeling of the acute impairment of cerebral blood flow was associated with disturbance of the thiol-disulfide balance, a decrease in NO-synthase activity, and an increase in the nitrotyrosine content, indicating the development of oxidative and nitrosative stress in brain tissue. Administration of thiotriazoline or α-lipoic acid resulted in the optimal ratio between the levels of reduced and oxidized thiol groups and glutathione, which demonstrates the active involvement of the thiol-disulfide system in the neutralization of products of free-radical oxidation. The effects of thiotriazoline or α-lipoic acid were related to the presence of thiol groups in their structures. Due to this, these drugs are able to normalize the glutathione system under conditions of oxidative stress.

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Correspondence to S. V. Gorbacheva.

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Original Russian Text © I.F. Belenichev, S.V. Gorbacheva, A.V. Demchenko, N.V. Bukhtiyarova, 2014, published in Neirokhimiya, 2014, Vol. 31, No. 1, pp. 31–35.

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Belenichev, I.F., Gorbacheva, S.V., Demchenko, A.V. et al. The thiol-disulfide balance and the nitric oxide system in the brain tissue of rats subjected to experimental acute impairment of cerebral blood flow: The therapeutic effects of nootropic drugs. Neurochem. J. 8, 24–27 (2014). https://doi.org/10.1134/S181971241401005X

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  • DOI: https://doi.org/10.1134/S181971241401005X

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