Abstract
Cytokines and indices of the lipid peroxidation and antioxidant defense system were investigated in the blood. Sixty-six patients with first-episode paranoid schizophrenia were included in this research. An increase in proinflammatory cytokines (IL1β, IL8, TNFα, and IFNα), immune interleukin 2, and a decrease in the anti-inflammatory interleukin 4 were observed in schizophrenic patients. An increase in lipoperoxidation and a decrease in glutathione peroxidase and glutathione reductase activity were found as well. We discuss some pathophysiological mechanisms of changes in cytokines, lipid peroxidation, and the antioxidant defense system.
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Original Russian Text © N.V. Ozornina, A.S. Ozornin, N.V. Govorin, 2013, published in Neirokhimiya, 2013, Vol. 30, No. 3, pp. 259–263.
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Ozornina, N.V., Ozornin, A.S. & Govorin, N.V. Possible pathophysiological mechanisms of changes in several cytokines and in the lipid peroxidation and antioxidant defense system in first-episode schizophrenia patients. Neurochem. J. 7, 230–233 (2013). https://doi.org/10.1134/S1819712413030112
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DOI: https://doi.org/10.1134/S1819712413030112