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The neurochemistry of the sleep-wakefulness cycle and Parkinson’s disease

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Abstract

Parkinson’s disease (PD) is one of the most socially relevant illnesses. Sleep disturbances in PD are common and manifold; they are present, according to different data, in 45–98% of all patients and include insomnia, parasomnia, hypersomnia, and other symptoms. Many of these symptoms appear several years before the development of movement disorders and may be regarded as early predictors of PD. We review the possible roles of the dopaminergic, orexin/hypocretinergic, and melaninergic cerebral structures in the development of PD sleep disorders, such as excessive daytime sleepiness, rapid eye movement sleep behavior disorders (RBD), and restless legs syndrome.

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References

  1. Osipov, Yu.S., Mozg. Fundamental’nye i prikladnye problemy (The Brain. Fundamental and Applied Problems), Moscow: Nauka, 2010, pp. 3–5.

    Google Scholar 

  2. Ugryumov, M.V., Mozg. Fundamental’nye i prikladnye problemy (The Brain. Fundamental and Applied Problems), Moscow: Nauka, 2010, pp. 29–49.

    Google Scholar 

  3. Ugryumov, M.V., Neirodegenerativnye zabolevaniya. Fundamental’nye i prikladnye aspekty (Neurodegenerative diseases. Fundamental and Applied Aspects), Moscow: Nauka, 2010, pp. 8–35.

    Google Scholar 

  4. Bhidayasiri, R. and Truong, D.D., Parkinsonism Relat. Disord., 2012, vol. 18,Suppl. 1, pp. S110–S113.

    Article  PubMed  Google Scholar 

  5. Chaudhuri, K.R., Odin, P., Antonini, A., and Martinez-Martin, P., Parkinsonism Relat. Disord., vol. 17, no. 10, pp. 717–723.

  6. Fernandez, H.H., CNS Spectr, 2008, vol. 13,Suppl. 4, pp. 6–11.

    Google Scholar 

  7. Pastukhov, Yu.F. and Chesnokova, A.Yu., Neirodegenerativnye zabolevaniya. Fundamental’nye i prikladnye aspekty (Neurodegenerative diseases. Fundamental and Applied Aspects), Moscow: Nauka, 2010, p. 189–2011.

    Google Scholar 

  8. McDowell, K. and Chesselet, M.-F., Neurobiol. Dis., vol. 46, 2012, pp. 597–606.

    Article  PubMed  Google Scholar 

  9. Braak, H., Ghebremedhin, E., Rub, U., Bratzke, H., and Del Tredici, K., Cell. Tissue Res, 2004, vol. 318, pp. 121–134.

    Article  PubMed  Google Scholar 

  10. Stern, M., Roffwarg, H., and Duvoisin, R., J. Nerv. Ment. Dis., vol. 147, no. 2, pp. 202–210.

  11. Bertolucci, P.H., Andrade, L.A., Lima, J.G., and Carlini, E.A., Arq. Neuropsiquiatr, 1987, vol. 45, no. 3, pp. 224–230.

    PubMed  CAS  Google Scholar 

  12. Factor, S.A., McAlarney, T., Sanchez-Ramos, J.R., and Wiener, W.J., Mov. Dis., vol. 5, no. 4, pp. 280–285.

  13. Gusev, E.I., Gekht, A.B., Popov, G.R., Volkova, N.A., Pastukhov, Yu.F., Pronina, T.S., Chesnokova, A.Yu., and Ekimova, I.V., Neirodegenerativnye zabolevaniya. Fundamental’nye i prikladnye aspekty (Neurodegenerative diseases. Fundamental and Applied Aspects), Moscow: Nauka, 2010, pp. 52–86.

    Google Scholar 

  14. Mehta, S.H., Morgan, J.C., and Sethi, K.D., CNS Spectr, 2008, vol. 13,Suppl. 4, pp. 6–11.

    PubMed  Google Scholar 

  15. Trenkwalder, C. and Arnulf, I., in Principles and Practice in Sleep Medicine, 5th ed., Kryger, M.H. and Roth, T., Dement, W.C., Eds., Elsevier: St. Louis, Missouri, 2011, pp. 980–992.

  16. Zoccolella, S., Savarese, M., Lamberti, P., Manni, R., Pacchetti, C., and Logroscino, G., Sleep Med. Rev., 2011, vol. 15, pp. 41–50.

    Article  PubMed  Google Scholar 

  17. De Cock, V.C., Vidailhet, M., and Arnulf, I., Nat. Clin. Pract. Neurol., 2008, vol. 4, no. 5, pp. 254–266.

    Article  PubMed  Google Scholar 

  18. De Cock, V.C., Vidailhet, M., Leu, S., Texeira, A., Apartis, E., Elbaz, A., Roze, E., Willer, J.C., Derenne, J.P., Agid, Y., and Arnulf, I., Brain, 2007, vol. 130, no. 2, pp. 450–456.

    Article  PubMed  Google Scholar 

  19. Postuma, R.B., Gagnon, J.-F., Vendette, M., and Montplaisir, J.Y., Mov. Dis., 2009, vol. 24, no. 15, pp. 2225–2232.

    Article  Google Scholar 

  20. Postuma, R.B., Gagnon, J.F., Vendette, M., and Montplaisir, J.Y., Brain, 2009, vol. 132, no. 12, pp. 3298–3307.

    Article  PubMed  CAS  Google Scholar 

  21. Schulte, E.C. and Winkelmann, J., J. Neurol., 2011, vol. 258,Suppl. 2, pp. S328–S335.

    Article  PubMed  Google Scholar 

  22. Vendette, M., Gagnon, J.F., Soucy, J.P., Gosselin, N., Postuma, R.B., Tuineag, M., Godin, I., and Montplaisir, J., Mov. Disord., 2011, vol. 26, no. 9, pp. 1717–1724.

    Article  PubMed  Google Scholar 

  23. Sil’kis, I.G., Neirokhimiya, 2009, vol. 26, no. 3, pp. 253–264.

    Google Scholar 

  24. Paus, S., Brecht, H.M., Koster, J., Seeger, G., Klockgether, T., and Wullner, U., Mov Disord, 2003, vol. 18, no. 6, pp. 659–667.

    Article  PubMed  Google Scholar 

  25. Iranzo, A., J. Neurol. Sci., 2011, vol. 310, pp. 283–285.

    Article  PubMed  Google Scholar 

  26. Koval’zon, V.M., Osnovy somnologii. Fiziologiya i neirokhimiya tsikla bodrstvovanie-son (The Bases of Somnology. Physiology and neurochemistry of wakefulness-sleep cycle), Moscow: Binom, 2011.

    Google Scholar 

  27. Koval’zon, V.M., Hum. Physiol., 2011, vol. 37, no. 4, pp. 500–508.

    Article  Google Scholar 

  28. Datta, S., Maclean, R.R., Neurosci. Biobehav. Rev., 2007, vol. 31, pp. 775–824.

    Article  PubMed  CAS  Google Scholar 

  29. Datta, S., Sleep Med, 2010, vol. 11, pp. 431–440.

    Article  PubMed  Google Scholar 

  30. Pace-Schott, E.F. and Hobson, J.A., Nat. Rev. Neurosci., 2002, vol. 3, pp. 591–605.

    PubMed  CAS  Google Scholar 

  31. Monti, J.M. and Jantos, H., Prog. Brain Res., 2008, vol. 172, pp. 625–646.

    Article  PubMed  CAS  Google Scholar 

  32. Wisor, J.P., Nishino, S., Sora, I., Uhl, G.H., Mignot, E., and Edgar, D.M., J. Neurosci., 2001, vol. 21, no. 5, pp. 1787–1794.

    PubMed  CAS  Google Scholar 

  33. Trulson, M.E., Preussler, D.W., and Howell, G.A., Neurosci. Let., 1981, vol. 26, no. 2, pp. 183–188.

    Article  CAS  Google Scholar 

  34. Steinfels, G.F., Heym, J., Strecker, R.E., and Jacobs, B.L., Brain Res., 1983, vol. 258, no. 2, pp. 217–228.

    Article  PubMed  CAS  Google Scholar 

  35. Miller, J.D., Farber, J., Gatz, P., Roffwarg, H., and German, D.C., Brain Res., 1983, vol. 273, pp. 133–141.

    Article  PubMed  CAS  Google Scholar 

  36. Trulson, M.E. and Preussler, D.W., Exp. Neurol., 1984, vol. 83, pp. 367–377.

    PubMed  CAS  Google Scholar 

  37. Lena, I., Parrot, S., Deschaux, O., Muffat-Joly, S., Sauvinet, V., Renaud, B., Suaud-Chagny, M.-F., and Gottesmann, C., J. Neurosci. Res., 2005, vol. 81, pp. 891–899.

    Article  PubMed  CAS  Google Scholar 

  38. Dahan, L., Astier, B., Vautrelle, N., and Urbain, N., Kosis, B., and Chouvet, G., Neuropsychopharm., 2007, vol. 32, pp. 1232–1241.

    Article  CAS  Google Scholar 

  39. Wightman, R.M. and Robinson, D.L., J. Neurochem., 2002, vol. 82, pp. 721–735.

    Article  PubMed  CAS  Google Scholar 

  40. Maloney, K.J., Mainville, L., and Jones, B.E., Eur. J. Neurosci, 2002, vol. 15, pp. 774–778.

    Article  PubMed  Google Scholar 

  41. Léger, L., Sapin, E., Goutagny, R., Peyron, C., Salvert, D., Fort, P., and Luppi, P.-H., J. Chem. Neuroanat., 2010, vol. 39, no. 4, pp. 262–271.

    Article  PubMed  Google Scholar 

  42. Kovacs, K.J., Neurochem. Int., 1998, vol. 33, pp. 287–297.

    Article  PubMed  CAS  Google Scholar 

  43. Luppi, P.-H., Clément, O., Sapin, E., Gervasoni, D., Peyron, C., Léger, L., Salvert, D., and Fort, P., Sleep Med. Rev., 2011, vol. 15, no. 3, pp. 153–163.

    Article  PubMed  Google Scholar 

  44. Solms, M., Front. Neurosci., 2009, vol. 3, no. 3, p. 453.

    Google Scholar 

  45. Lima, M.M.S., Andersen, M.L., Reksidler, A.B., Vital, M.A.B.F., and Tufik, S., PLoS ONE, 2007, vol. 2, no. 6, p. e513.

    Article  PubMed  Google Scholar 

  46. Lena, I., Deschaux, O., Muffat, S., Parrot, S., Sauvinet, V., Suaud-Chagny, M.-F., Renaud, B., and Gottesmann, C., J. Sleep Res., 2004, vol. 13,Suppl. 1, p. 141.

    Google Scholar 

  47. Jouvet, M., Zamok Snov (Castle of Dreams), Russian Transl. by V.M. Kovalzon, Fryazino: Vek-2, 2006.

    Google Scholar 

  48. Jouvet, M., Pokhititel’ snov (Dream Thief), Russian transl. by V.M. Kovalzon and V.V. Nezgovorova, Moscow, Vremya, 2008.

    Google Scholar 

  49. Sil’kis, I.G., Neirokhimiya, 2006, vol. 23, no. 4, pp. 283–293.

    Google Scholar 

  50. Takakusaki, K., Saitoh, K., Harada, H., Okumura, T., and Sakamoto, T., Neuroscience, 2004, vol. 124, pp. 207–220.

    Article  PubMed  CAS  Google Scholar 

  51. Monaca, C., Laloux, C., Jacquesson, J.-M., Gelé, P., Maréchal, X., Bordet, R., Destée, A., and Derambure, P., Eur. J. Neurosci, 2004, vol. 20, no. 9, pp. 2474–2478.

    Article  PubMed  Google Scholar 

  52. Laloux, C., Derambure, P., Kreisler, A., and Houdayer, E., Brueziere, S., Bordet, R., Destée, A., Monaca, C., Exp. Brain Res., 2008, vol. 186, pp. 635–642.

    Article  PubMed  Google Scholar 

  53. Laloux, C., Derambure, P., Jacquesson, J.-M., Bordet, R., Destée, A., and Monaca, C., Brain Res., 2007, vol. 1161, pp. 79–87.

    Article  PubMed  CAS  Google Scholar 

  54. Pastukhov, Yu.F., Chesnokova, A.Yu., Yakimchuk, A.A., Ekimova, I.V., Romanova, I.V., and Khudik, K.A., Ros. fiziol. zhurn. im. I. M. Sechenova, 2010, vol. 96, no. 12, pp. 1190–1202.

    CAS  Google Scholar 

  55. Giovanni, A., Sieber, B.A., Heikkila, R.E., and Sonsalla, P.K., J. Pharmacol. Exp. Ther., 1994, vol. 270, no. 3, pp. 1000–1007.

    PubMed  CAS  Google Scholar 

  56. Aznavour, N., Cendres-Bozzi, C., Lemoine, L., Buda, C., Sastre, J.-P., Mincheva, Z., Zimmer, L., and Lin J.-S., CNS Neurosci. Ther., 2012, vol. 18, pp. 934–941.

    Article  PubMed  Google Scholar 

  57. Pungor, K., Papp, M., Kékesi, K., and Juhász, G., Brain Res., 1990, vol. 525, no. 2, pp. 310–314.

    Article  PubMed  CAS  Google Scholar 

  58. Almirall, H., Pigarev, I.N., de la Calzada, M.D., Pigareva, M.L., Sagales, T., and Herrero, M.T., J. Neural Transm., 1999, vol. 106, pp. 1125–1134.

    Article  PubMed  CAS  Google Scholar 

  59. Barraud, Q., Lambrecq, V., Forni, C., McGuire, S., Hill, M., Bioulac, B., Balzamo, E., Bezard, E., Tison, F., and Ghorayeb, I., Exp. Neur., 2009, vol. 219, pp. 574–582.

    Article  CAS  Google Scholar 

  60. Verhave, P.S., Jongsma, M.J., Berg, R.M., Vis, J.C., Vanwersch, R.A.P., Smit, A.B., Van Someren, E.J.W., and Philippens, I.H.C.H.M., Sleep, 2011, vol. 34, no. 8, pp. 1119–1125.

    PubMed  Google Scholar 

  61. Abbott, R.D., Ross, G.W., White, L.R., Tanner, C.M., Masaki, K.H., Nelson, J.S., Curb, J.D., and Petrovitch, H., Neurology, 2005, vol. 65, no. 9, pp. 1442–1446.

    Article  PubMed  CAS  Google Scholar 

  62. Arnulf, I., Konofal, E., Merino-Andreu, M., Houeto, J.L., Mesnage, V., Welter, M.L., Lacomblez, L., Golmard, J.L., Derenne, J.P., and Agid, Y., Neurology, 2002, vol. 58, no. 7, pp. 1019–1024.

    Article  PubMed  CAS  Google Scholar 

  63. Rye, D.B., Bliwise, D.L., Dihenia, B., and Gurecki, P., J. Sleep Res., 2000, vol. 9, pp. 63–69.

    Article  PubMed  CAS  Google Scholar 

  64. Bonnavion, P. and de Lecea, L., Curr. Neurol. Neurosci. Rep., 2010, vol. 10, pp. 174–179.

    Article  PubMed  CAS  Google Scholar 

  65. De la Herrán-Arita, A.K., Guerra-Crespo, M., and Drucker-Colín, R., Front. Neurol., 2011, vol. 2, article 26.

  66. Mignot, E., Front. Neurosci., 2009, vol. 3, no. 3, pp. 426–427.

    Google Scholar 

  67. Arnulf, I., Bonnet, A.-M., Damier, P., Bejjani, B.-P., Seilhean, D., Derenne, J.-P., and Agid, Y., Neurology, 2000, vol. 55, pp. 281–288.

    Article  PubMed  CAS  Google Scholar 

  68. Fronczek, R., Overeem, S., Lee, S.Y.Y., Hegeman, I.M., van Pelt, J., van Duinen, S.G., Lammers, G.J., and Swaab, D.F., Brain, 2007, vol. 130, pp. 1577–1585.

    Article  PubMed  Google Scholar 

  69. Fronczek, R., Overeem, S., Lee, S.Y.Y., Hegeman, I.M., van Pelt, J., van Duinen, S.G., Lammers, G.J., and Swaab, D.F., Brain, 2008, vol. 131, p. e88.

    Article  PubMed  Google Scholar 

  70. Thannickal, T.C., Lai, Y.-Y., and Siegel, J.M., Brain, 2007, vol. 130, pp. 1586–1595.

    Article  PubMed  Google Scholar 

  71. Thannickal, T.C., Lai, Y.-Y., and Siegel, J.M., Brain, 2008, vol. 131, p. e87.

  72. Torterolo, P., Lagos, P., and Monti, J.M., Front. Neurol, 2011, vol. 2, Art. 14.

  73. Nakamura, T., Uramura, K., Nambu, T., Yada, T., Goto, K., Yanagisawa, M., and Sakurai, T., Brain Res., 2000, vol. 873, pp. 181–187.

    Article  PubMed  CAS  Google Scholar 

  74. Baumann, C.R., Scammell, T.E., and Bassetti, C.L., Brain, 2008, vol. 131, p. e91.

    Article  PubMed  Google Scholar 

  75. Narcolepsy: Pathophysiology, Diagnosis, and Treatment, Bassetti, C.L., Baumann, C.R., and Scammell, T.E., Eds., Springer: Berlin, 2011.

    Google Scholar 

  76. Wienecke, M., Werth, E., Poryazova, R., Baumann-Vogel, H., Bassetti, C.L., Weller, M., Waldvogel, D., Storch, A., and Baumann, C.R., J. Sleep Res., 2012, vol. 21, no. 6, pp. 710–717.

    Article  PubMed  Google Scholar 

  77. Monti, J.M. and Monti, D., Sleep Med. Rev, 2007, vol. 11, pp. 113–133.

    Article  PubMed  Google Scholar 

  78. Dzirasa, K., Ribeiro, S., Costa, R., Santos, L.M., Lin, S.-C., Grosmark, A., Sotnikova, T.D., Gainetdinov, R.R., Caron, M.G., and Nicolelis, M.A.L., J. Neurosci., 2006, vol. 26, no. 41, pp. 10577–10589.

    Article  PubMed  CAS  Google Scholar 

  79. Litvinenko, I.V., Krasakov, I.V., and Tikhomirova, O.V., in Bolezn’ Parkinsona i rasstroistva dvizhenii (Parkinson disease and movement disorders), Moscow: NTsN RAMN, 2011, pp. 92–98.

    Google Scholar 

  80. Jouvet, M. and Delorme, F., C. R. Soc. Biol, 1965, vol. 159, pp. 895–899.

    Google Scholar 

  81. Morrison, E.R., Scientific American, 1983, no. 6, pp. 62–71.

    Google Scholar 

  82. Morrison, A.R., Arch. Ital. Biol, 1988, vol. 126, pp. 275–289.

    PubMed  CAS  Google Scholar 

  83. Sanford, L.D., Cheng, C.S., Silvestri, A.J., Tang, X., Mann, G.L., Ross, R.J., and Morrison, A.R., Sleep Res. Online, 2001, vol. 4, no. 1, pp. 1–5.

    Google Scholar 

  84. Lai, Y.-Y., Kodama, T., Schenkel, E., and Siegel, J.M., J. Neurophysiol., 2010, vol. 104, pp. 2024–2033.

    Article  PubMed  Google Scholar 

  85. Schenck, C.H., Bundlie, S.R., Ettinger, M.G., and Mahowald, M.W., Sleep, vol. 9, no. 2, pp. 293–308.

  86. Boeve, B.F., Silber, M.H., Saper, C.B., Ferman, T.J., Dickson, D.W., Parisi, J.E., Benarroch, E.E., Ahlskog, J.E., Smith, G.E., Caselli, R.C., Tippman-Peikert, M., Olson, E.J., Lin, S.-C., Young, T., Wszolek, Z., Schenck, C.H., Mahowald, M.W., Castillo, P.R., Del Tredici, K., and Braak, H., Brain, 2007, vol. 130, pp. 2770–2788.

    Article  PubMed  CAS  Google Scholar 

  87. Boeve, B.F., Ann. New York Acad. Sci., 2010, vol. 1184, no. 1, pp. 15–54.

    Article  CAS  Google Scholar 

  88. Montplaisir, J., Allen, R.P., Walters, A., and Ferini-Strambi, L., in Principles and Practice in Sleep Medicine, 5th ed., Kryger, M.H., Roth, T., and Dement, W.C, Eds., Elsevier: St.Louis, Missouri, 2011, pp. 1026–1037.

  89. Garcia-Borreguero, D., Larrosa, O., Granizo, J.J., de la Llave, Y., and Hening, W.A., Sleep, vol. 27, no. 4, pp. 669–673.

  90. Earley, C.J., Barker, B.P., Horska, A., and Allen, R.P., Sleep Med., 2006, vol. 7, no. 5, pp. 458–461.

    Article  PubMed  Google Scholar 

  91. Rothman, S.M. and Mattson, M.P., Neuromol. Med., 2012, vol. 14, pp. 194–204.

    Article  CAS  Google Scholar 

  92. Goldberg, N.R., Haack, A.K., and Lim, N.S., Janson, O.K., and Meshul, C.K., Neuroscience, 2011, vol. 180, pp. 256–271.

    Article  PubMed  CAS  Google Scholar 

  93. Kudo, T., Loh, D.H., Truong, D., Wu, Y., and Colwell, C.S., Exp. Neurol., 2011, vol. 232, pp. 66–75.

    Article  PubMed  Google Scholar 

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  1. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia

    V. M. Kovalzon & I. M. Zavalko

  2. Leninskii pr. 33, Moscow, 119071, Russia

    V. M. Kovalzon

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Original Russian Text © V.M. Kovalzon, I.M. Zavalko, 2013, published in Neirokhimiya, 2013, Vol. 30, No. 3, pp. 193–206.

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Kovalzon, V.M., Zavalko, I.M. The neurochemistry of the sleep-wakefulness cycle and Parkinson’s disease. Neurochem. J. 7, 171–183 (2013). https://doi.org/10.1134/S1819712413030069

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