Advertisement

Neurochemical Journal

, Volume 7, Issue 3, pp 171–183 | Cite as

The neurochemistry of the sleep-wakefulness cycle and Parkinson’s disease

  • V. M. Kovalzon
  • I. M. Zavalko
Review Articles

Abstract

Parkinson’s disease (PD) is one of the most socially relevant illnesses. Sleep disturbances in PD are common and manifold; they are present, according to different data, in 45–98% of all patients and include insomnia, parasomnia, hypersomnia, and other symptoms. Many of these symptoms appear several years before the development of movement disorders and may be regarded as early predictors of PD. We review the possible roles of the dopaminergic, orexin/hypocretinergic, and melaninergic cerebral structures in the development of PD sleep disorders, such as excessive daytime sleepiness, rapid eye movement sleep behavior disorders (RBD), and restless legs syndrome.

Keywords

sleep disorders Parkinson’s disease excessive daytime sleepiness REM sleep behavior disorders (RBD) restless legs syndrome 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Osipov, Yu.S., Mozg. Fundamental’nye i prikladnye problemy (The Brain. Fundamental and Applied Problems), Moscow: Nauka, 2010, pp. 3–5.Google Scholar
  2. 2.
    Ugryumov, M.V., Mozg. Fundamental’nye i prikladnye problemy (The Brain. Fundamental and Applied Problems), Moscow: Nauka, 2010, pp. 29–49.Google Scholar
  3. 3.
    Ugryumov, M.V., Neirodegenerativnye zabolevaniya. Fundamental’nye i prikladnye aspekty (Neurodegenerative diseases. Fundamental and Applied Aspects), Moscow: Nauka, 2010, pp. 8–35.Google Scholar
  4. 4.
    Bhidayasiri, R. and Truong, D.D., Parkinsonism Relat. Disord., 2012, vol. 18,Suppl. 1, pp. S110–S113.PubMedCrossRefGoogle Scholar
  5. 5.
    Chaudhuri, K.R., Odin, P., Antonini, A., and Martinez-Martin, P., Parkinsonism Relat. Disord., vol. 17, no. 10, pp. 717–723.Google Scholar
  6. 6.
    Fernandez, H.H., CNS Spectr, 2008, vol. 13,Suppl. 4, pp. 6–11.Google Scholar
  7. 7.
    Pastukhov, Yu.F. and Chesnokova, A.Yu., Neirodegenerativnye zabolevaniya. Fundamental’nye i prikladnye aspekty (Neurodegenerative diseases. Fundamental and Applied Aspects), Moscow: Nauka, 2010, p. 189–2011.Google Scholar
  8. 8.
    McDowell, K. and Chesselet, M.-F., Neurobiol. Dis., vol. 46, 2012, pp. 597–606.PubMedCrossRefGoogle Scholar
  9. 9.
    Braak, H., Ghebremedhin, E., Rub, U., Bratzke, H., and Del Tredici, K., Cell. Tissue Res, 2004, vol. 318, pp. 121–134.PubMedCrossRefGoogle Scholar
  10. 10.
    Stern, M., Roffwarg, H., and Duvoisin, R., J. Nerv. Ment. Dis., vol. 147, no. 2, pp. 202–210.Google Scholar
  11. 11.
    Bertolucci, P.H., Andrade, L.A., Lima, J.G., and Carlini, E.A., Arq. Neuropsiquiatr, 1987, vol. 45, no. 3, pp. 224–230.PubMedGoogle Scholar
  12. 12.
    Factor, S.A., McAlarney, T., Sanchez-Ramos, J.R., and Wiener, W.J., Mov. Dis., vol. 5, no. 4, pp. 280–285.Google Scholar
  13. 13.
    Gusev, E.I., Gekht, A.B., Popov, G.R., Volkova, N.A., Pastukhov, Yu.F., Pronina, T.S., Chesnokova, A.Yu., and Ekimova, I.V., Neirodegenerativnye zabolevaniya. Fundamental’nye i prikladnye aspekty (Neurodegenerative diseases. Fundamental and Applied Aspects), Moscow: Nauka, 2010, pp. 52–86.Google Scholar
  14. 14.
    Mehta, S.H., Morgan, J.C., and Sethi, K.D., CNS Spectr, 2008, vol. 13,Suppl. 4, pp. 6–11.PubMedGoogle Scholar
  15. 15.
    Trenkwalder, C. and Arnulf, I., in Principles and Practice in Sleep Medicine, 5th ed., Kryger, M.H. and Roth, T., Dement, W.C., Eds., Elsevier: St. Louis, Missouri, 2011, pp. 980–992.Google Scholar
  16. 16.
    Zoccolella, S., Savarese, M., Lamberti, P., Manni, R., Pacchetti, C., and Logroscino, G., Sleep Med. Rev., 2011, vol. 15, pp. 41–50.PubMedCrossRefGoogle Scholar
  17. 17.
    De Cock, V.C., Vidailhet, M., and Arnulf, I., Nat. Clin. Pract. Neurol., 2008, vol. 4, no. 5, pp. 254–266.PubMedCrossRefGoogle Scholar
  18. 18.
    De Cock, V.C., Vidailhet, M., Leu, S., Texeira, A., Apartis, E., Elbaz, A., Roze, E., Willer, J.C., Derenne, J.P., Agid, Y., and Arnulf, I., Brain, 2007, vol. 130, no. 2, pp. 450–456.PubMedCrossRefGoogle Scholar
  19. 19.
    Postuma, R.B., Gagnon, J.-F., Vendette, M., and Montplaisir, J.Y., Mov. Dis., 2009, vol. 24, no. 15, pp. 2225–2232.CrossRefGoogle Scholar
  20. 20.
    Postuma, R.B., Gagnon, J.F., Vendette, M., and Montplaisir, J.Y., Brain, 2009, vol. 132, no. 12, pp. 3298–3307.PubMedCrossRefGoogle Scholar
  21. 21.
    Schulte, E.C. and Winkelmann, J., J. Neurol., 2011, vol. 258,Suppl. 2, pp. S328–S335.PubMedCrossRefGoogle Scholar
  22. 22.
    Vendette, M., Gagnon, J.F., Soucy, J.P., Gosselin, N., Postuma, R.B., Tuineag, M., Godin, I., and Montplaisir, J., Mov. Disord., 2011, vol. 26, no. 9, pp. 1717–1724.PubMedCrossRefGoogle Scholar
  23. 23.
    Sil’kis, I.G., Neirokhimiya, 2009, vol. 26, no. 3, pp. 253–264.Google Scholar
  24. 24.
    Paus, S., Brecht, H.M., Koster, J., Seeger, G., Klockgether, T., and Wullner, U., Mov Disord, 2003, vol. 18, no. 6, pp. 659–667.PubMedCrossRefGoogle Scholar
  25. 25.
    Iranzo, A., J. Neurol. Sci., 2011, vol. 310, pp. 283–285.PubMedCrossRefGoogle Scholar
  26. 26.
    Koval’zon, V.M., Osnovy somnologii. Fiziologiya i neirokhimiya tsikla bodrstvovanie-son (The Bases of Somnology. Physiology and neurochemistry of wakefulness-sleep cycle), Moscow: Binom, 2011.Google Scholar
  27. 27.
    Koval’zon, V.M., Hum. Physiol., 2011, vol. 37, no. 4, pp. 500–508.CrossRefGoogle Scholar
  28. 28.
    Datta, S., Maclean, R.R., Neurosci. Biobehav. Rev., 2007, vol. 31, pp. 775–824.PubMedCrossRefGoogle Scholar
  29. 29.
    Datta, S., Sleep Med, 2010, vol. 11, pp. 431–440.PubMedCrossRefGoogle Scholar
  30. 30.
    Pace-Schott, E.F. and Hobson, J.A., Nat. Rev. Neurosci., 2002, vol. 3, pp. 591–605.PubMedGoogle Scholar
  31. 31.
    Monti, J.M. and Jantos, H., Prog. Brain Res., 2008, vol. 172, pp. 625–646.PubMedCrossRefGoogle Scholar
  32. 32.
    Wisor, J.P., Nishino, S., Sora, I., Uhl, G.H., Mignot, E., and Edgar, D.M., J. Neurosci., 2001, vol. 21, no. 5, pp. 1787–1794.PubMedGoogle Scholar
  33. 33.
    Trulson, M.E., Preussler, D.W., and Howell, G.A., Neurosci. Let., 1981, vol. 26, no. 2, pp. 183–188.CrossRefGoogle Scholar
  34. 34.
    Steinfels, G.F., Heym, J., Strecker, R.E., and Jacobs, B.L., Brain Res., 1983, vol. 258, no. 2, pp. 217–228.PubMedCrossRefGoogle Scholar
  35. 35.
    Miller, J.D., Farber, J., Gatz, P., Roffwarg, H., and German, D.C., Brain Res., 1983, vol. 273, pp. 133–141.PubMedCrossRefGoogle Scholar
  36. 36.
    Trulson, M.E. and Preussler, D.W., Exp. Neurol., 1984, vol. 83, pp. 367–377.PubMedGoogle Scholar
  37. 37.
    Lena, I., Parrot, S., Deschaux, O., Muffat-Joly, S., Sauvinet, V., Renaud, B., Suaud-Chagny, M.-F., and Gottesmann, C., J. Neurosci. Res., 2005, vol. 81, pp. 891–899.PubMedCrossRefGoogle Scholar
  38. 38.
    Dahan, L., Astier, B., Vautrelle, N., and Urbain, N., Kosis, B., and Chouvet, G., Neuropsychopharm., 2007, vol. 32, pp. 1232–1241.CrossRefGoogle Scholar
  39. 39.
    Wightman, R.M. and Robinson, D.L., J. Neurochem., 2002, vol. 82, pp. 721–735.PubMedCrossRefGoogle Scholar
  40. 40.
    Maloney, K.J., Mainville, L., and Jones, B.E., Eur. J. Neurosci, 2002, vol. 15, pp. 774–778.PubMedCrossRefGoogle Scholar
  41. 41.
    Léger, L., Sapin, E., Goutagny, R., Peyron, C., Salvert, D., Fort, P., and Luppi, P.-H., J. Chem. Neuroanat., 2010, vol. 39, no. 4, pp. 262–271.PubMedCrossRefGoogle Scholar
  42. 42.
    Kovacs, K.J., Neurochem. Int., 1998, vol. 33, pp. 287–297.PubMedCrossRefGoogle Scholar
  43. 43.
    Luppi, P.-H., Clément, O., Sapin, E., Gervasoni, D., Peyron, C., Léger, L., Salvert, D., and Fort, P., Sleep Med. Rev., 2011, vol. 15, no. 3, pp. 153–163.PubMedCrossRefGoogle Scholar
  44. 44.
    Solms, M., Front. Neurosci., 2009, vol. 3, no. 3, p. 453.Google Scholar
  45. 45.
    Lima, M.M.S., Andersen, M.L., Reksidler, A.B., Vital, M.A.B.F., and Tufik, S., PLoS ONE, 2007, vol. 2, no. 6, p. e513.PubMedCrossRefGoogle Scholar
  46. 46.
    Lena, I., Deschaux, O., Muffat, S., Parrot, S., Sauvinet, V., Suaud-Chagny, M.-F., Renaud, B., and Gottesmann, C., J. Sleep Res., 2004, vol. 13,Suppl. 1, p. 141.Google Scholar
  47. 47.
    Jouvet, M., Zamok Snov (Castle of Dreams), Russian Transl. by V.M. Kovalzon, Fryazino: Vek-2, 2006.Google Scholar
  48. 48.
    Jouvet, M., Pokhititel’ snov (Dream Thief), Russian transl. by V.M. Kovalzon and V.V. Nezgovorova, Moscow, Vremya, 2008.Google Scholar
  49. 49.
    Sil’kis, I.G., Neirokhimiya, 2006, vol. 23, no. 4, pp. 283–293.Google Scholar
  50. 50.
    Takakusaki, K., Saitoh, K., Harada, H., Okumura, T., and Sakamoto, T., Neuroscience, 2004, vol. 124, pp. 207–220.PubMedCrossRefGoogle Scholar
  51. 51.
    Monaca, C., Laloux, C., Jacquesson, J.-M., Gelé, P., Maréchal, X., Bordet, R., Destée, A., and Derambure, P., Eur. J. Neurosci, 2004, vol. 20, no. 9, pp. 2474–2478.PubMedCrossRefGoogle Scholar
  52. 52.
    Laloux, C., Derambure, P., Kreisler, A., and Houdayer, E., Brueziere, S., Bordet, R., Destée, A., Monaca, C., Exp. Brain Res., 2008, vol. 186, pp. 635–642.PubMedCrossRefGoogle Scholar
  53. 53.
    Laloux, C., Derambure, P., Jacquesson, J.-M., Bordet, R., Destée, A., and Monaca, C., Brain Res., 2007, vol. 1161, pp. 79–87.PubMedCrossRefGoogle Scholar
  54. 54.
    Pastukhov, Yu.F., Chesnokova, A.Yu., Yakimchuk, A.A., Ekimova, I.V., Romanova, I.V., and Khudik, K.A., Ros. fiziol. zhurn. im. I. M. Sechenova, 2010, vol. 96, no. 12, pp. 1190–1202.Google Scholar
  55. 55.
    Giovanni, A., Sieber, B.A., Heikkila, R.E., and Sonsalla, P.K., J. Pharmacol. Exp. Ther., 1994, vol. 270, no. 3, pp. 1000–1007.PubMedGoogle Scholar
  56. 56.
    Aznavour, N., Cendres-Bozzi, C., Lemoine, L., Buda, C., Sastre, J.-P., Mincheva, Z., Zimmer, L., and Lin J.-S., CNS Neurosci. Ther., 2012, vol. 18, pp. 934–941.PubMedCrossRefGoogle Scholar
  57. 57.
    Pungor, K., Papp, M., Kékesi, K., and Juhász, G., Brain Res., 1990, vol. 525, no. 2, pp. 310–314.PubMedCrossRefGoogle Scholar
  58. 58.
    Almirall, H., Pigarev, I.N., de la Calzada, M.D., Pigareva, M.L., Sagales, T., and Herrero, M.T., J. Neural Transm., 1999, vol. 106, pp. 1125–1134.PubMedCrossRefGoogle Scholar
  59. 59.
    Barraud, Q., Lambrecq, V., Forni, C., McGuire, S., Hill, M., Bioulac, B., Balzamo, E., Bezard, E., Tison, F., and Ghorayeb, I., Exp. Neur., 2009, vol. 219, pp. 574–582.CrossRefGoogle Scholar
  60. 60.
    Verhave, P.S., Jongsma, M.J., Berg, R.M., Vis, J.C., Vanwersch, R.A.P., Smit, A.B., Van Someren, E.J.W., and Philippens, I.H.C.H.M., Sleep, 2011, vol. 34, no. 8, pp. 1119–1125.PubMedGoogle Scholar
  61. 61.
    Abbott, R.D., Ross, G.W., White, L.R., Tanner, C.M., Masaki, K.H., Nelson, J.S., Curb, J.D., and Petrovitch, H., Neurology, 2005, vol. 65, no. 9, pp. 1442–1446.PubMedCrossRefGoogle Scholar
  62. 62.
    Arnulf, I., Konofal, E., Merino-Andreu, M., Houeto, J.L., Mesnage, V., Welter, M.L., Lacomblez, L., Golmard, J.L., Derenne, J.P., and Agid, Y., Neurology, 2002, vol. 58, no. 7, pp. 1019–1024.PubMedCrossRefGoogle Scholar
  63. 63.
    Rye, D.B., Bliwise, D.L., Dihenia, B., and Gurecki, P., J. Sleep Res., 2000, vol. 9, pp. 63–69.PubMedCrossRefGoogle Scholar
  64. 64.
    Bonnavion, P. and de Lecea, L., Curr. Neurol. Neurosci. Rep., 2010, vol. 10, pp. 174–179.PubMedCrossRefGoogle Scholar
  65. 65.
    De la Herrán-Arita, A.K., Guerra-Crespo, M., and Drucker-Colín, R., Front. Neurol., 2011, vol. 2, article 26.Google Scholar
  66. 66.
    Mignot, E., Front. Neurosci., 2009, vol. 3, no. 3, pp. 426–427.Google Scholar
  67. 67.
    Arnulf, I., Bonnet, A.-M., Damier, P., Bejjani, B.-P., Seilhean, D., Derenne, J.-P., and Agid, Y., Neurology, 2000, vol. 55, pp. 281–288.PubMedCrossRefGoogle Scholar
  68. 68.
    Fronczek, R., Overeem, S., Lee, S.Y.Y., Hegeman, I.M., van Pelt, J., van Duinen, S.G., Lammers, G.J., and Swaab, D.F., Brain, 2007, vol. 130, pp. 1577–1585.PubMedCrossRefGoogle Scholar
  69. 69.
    Fronczek, R., Overeem, S., Lee, S.Y.Y., Hegeman, I.M., van Pelt, J., van Duinen, S.G., Lammers, G.J., and Swaab, D.F., Brain, 2008, vol. 131, p. e88.PubMedCrossRefGoogle Scholar
  70. 70.
    Thannickal, T.C., Lai, Y.-Y., and Siegel, J.M., Brain, 2007, vol. 130, pp. 1586–1595.PubMedCrossRefGoogle Scholar
  71. 71.
    Thannickal, T.C., Lai, Y.-Y., and Siegel, J.M., Brain, 2008, vol. 131, p. e87.Google Scholar
  72. 72.
    Torterolo, P., Lagos, P., and Monti, J.M., Front. Neurol, 2011, vol. 2, Art. 14.Google Scholar
  73. 73.
    Nakamura, T., Uramura, K., Nambu, T., Yada, T., Goto, K., Yanagisawa, M., and Sakurai, T., Brain Res., 2000, vol. 873, pp. 181–187.PubMedCrossRefGoogle Scholar
  74. 74.
    Baumann, C.R., Scammell, T.E., and Bassetti, C.L., Brain, 2008, vol. 131, p. e91.PubMedCrossRefGoogle Scholar
  75. 75.
    Narcolepsy: Pathophysiology, Diagnosis, and Treatment, Bassetti, C.L., Baumann, C.R., and Scammell, T.E., Eds., Springer: Berlin, 2011.Google Scholar
  76. 76.
    Wienecke, M., Werth, E., Poryazova, R., Baumann-Vogel, H., Bassetti, C.L., Weller, M., Waldvogel, D., Storch, A., and Baumann, C.R., J. Sleep Res., 2012, vol. 21, no. 6, pp. 710–717.PubMedCrossRefGoogle Scholar
  77. 77.
    Monti, J.M. and Monti, D., Sleep Med. Rev, 2007, vol. 11, pp. 113–133.PubMedCrossRefGoogle Scholar
  78. 78.
    Dzirasa, K., Ribeiro, S., Costa, R., Santos, L.M., Lin, S.-C., Grosmark, A., Sotnikova, T.D., Gainetdinov, R.R., Caron, M.G., and Nicolelis, M.A.L., J. Neurosci., 2006, vol. 26, no. 41, pp. 10577–10589.PubMedCrossRefGoogle Scholar
  79. 79.
    Litvinenko, I.V., Krasakov, I.V., and Tikhomirova, O.V., in Bolezn’ Parkinsona i rasstroistva dvizhenii (Parkinson disease and movement disorders), Moscow: NTsN RAMN, 2011, pp. 92–98.Google Scholar
  80. 80.
    Jouvet, M. and Delorme, F., C. R. Soc. Biol, 1965, vol. 159, pp. 895–899.Google Scholar
  81. 81.
    Morrison, E.R., Scientific American, 1983, no. 6, pp. 62–71.Google Scholar
  82. 82.
    Morrison, A.R., Arch. Ital. Biol, 1988, vol. 126, pp. 275–289.PubMedGoogle Scholar
  83. 83.
    Sanford, L.D., Cheng, C.S., Silvestri, A.J., Tang, X., Mann, G.L., Ross, R.J., and Morrison, A.R., Sleep Res. Online, 2001, vol. 4, no. 1, pp. 1–5.Google Scholar
  84. 84.
    Lai, Y.-Y., Kodama, T., Schenkel, E., and Siegel, J.M., J. Neurophysiol., 2010, vol. 104, pp. 2024–2033.PubMedCrossRefGoogle Scholar
  85. 85.
    Schenck, C.H., Bundlie, S.R., Ettinger, M.G., and Mahowald, M.W., Sleep, vol. 9, no. 2, pp. 293–308.Google Scholar
  86. 86.
    Boeve, B.F., Silber, M.H., Saper, C.B., Ferman, T.J., Dickson, D.W., Parisi, J.E., Benarroch, E.E., Ahlskog, J.E., Smith, G.E., Caselli, R.C., Tippman-Peikert, M., Olson, E.J., Lin, S.-C., Young, T., Wszolek, Z., Schenck, C.H., Mahowald, M.W., Castillo, P.R., Del Tredici, K., and Braak, H., Brain, 2007, vol. 130, pp. 2770–2788.PubMedCrossRefGoogle Scholar
  87. 87.
    Boeve, B.F., Ann. New York Acad. Sci., 2010, vol. 1184, no. 1, pp. 15–54.CrossRefGoogle Scholar
  88. 88.
    Montplaisir, J., Allen, R.P., Walters, A., and Ferini-Strambi, L., in Principles and Practice in Sleep Medicine, 5th ed., Kryger, M.H., Roth, T., and Dement, W.C, Eds., Elsevier: St.Louis, Missouri, 2011, pp. 1026–1037.Google Scholar
  89. 89.
    Garcia-Borreguero, D., Larrosa, O., Granizo, J.J., de la Llave, Y., and Hening, W.A., Sleep, vol. 27, no. 4, pp. 669–673.Google Scholar
  90. 90.
    Earley, C.J., Barker, B.P., Horska, A., and Allen, R.P., Sleep Med., 2006, vol. 7, no. 5, pp. 458–461.PubMedCrossRefGoogle Scholar
  91. 91.
    Rothman, S.M. and Mattson, M.P., Neuromol. Med., 2012, vol. 14, pp. 194–204.CrossRefGoogle Scholar
  92. 92.
    Goldberg, N.R., Haack, A.K., and Lim, N.S., Janson, O.K., and Meshul, C.K., Neuroscience, 2011, vol. 180, pp. 256–271.PubMedCrossRefGoogle Scholar
  93. 93.
    Kudo, T., Loh, D.H., Truong, D., Wu, Y., and Colwell, C.S., Exp. Neurol., 2011, vol. 232, pp. 66–75.PubMedCrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  1. 1.Severtsov Institute of Ecology and EvolutionRussian Academy of SciencesMoscowRussia
  2. 2.MoscowRussia

Personalised recommendations