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Neurochemical Journal

, Volume 6, Issue 4, pp 307–310 | Cite as

Involvement of the 5-HT1A and 5-HT2A/2C serotonin receptors in the anxious behavior of prenatally stressed ovariectomized rats

  • Yu. O. Fedotova
  • S. G. Pivina
  • N. E. Ordyan
Experimental Articles
  • 55 Downloads

Abstract

We compared the effects of an antagonist of 5-HT1A receptors, NAN-190 (0.1 mg/kg intraperitoneally), and an antagonist of 5-HT2A/2C receptors, ketanserin (0.1 mg/kg intraperitoneally), which were chronically injected for 14 days, on the anxiety level in prenatally stressed female rats with an ovariectomyinduced experimental deficiency of estrogens. Chronic administration of ketanserin to ovariectomized prenatally stressed females had an anxiolytic effect and corrected disturbed levels of follitropin, lutropin, and estradiol. Administration of NAN-190 to ovariectomized prenatally stressed rats increased the anxiety level and decreased the ratio between the levels of tropic and peripheral sex hormones.

Keywords

NAN-190 ketanserin serotonin receptors anxiety hormonal status ovariectomy prenatal stress 

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • Yu. O. Fedotova
    • 1
    • 2
  • S. G. Pivina
    • 1
  • N. E. Ordyan
    • 1
  1. 1.Laboratory of Endocrinology, Pavlov Institute of PhysiologyRussian Academy of SciencesSt. PetersburgRussia
  2. 2.St. PetersburgRussia

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