Neurochemical Journal

, Volume 6, Issue 1, pp 38–43 | Cite as

Monoamine metabolism in the brain of rats with chronic heart failure of non-ischemic origin

Experimental Articles


Chronic heart failure (CHF) modulates the activity of monoaminergic systems in the central nervous system (CNS). An increased dioxyphenylacetic acid/dopamine ratio and 5-oxyindoleacetic acid/serotonin ratio in the majority of the brain structures studied during CHF indicate the high activity of the dopamine and serotonin systems and their functional stress during the development of hypoxia-compensative processes aimed at the maintenance of the normal cerebral blood flow. However, if a convulsive seizure develops during CHF, it may result in the failure of compensatory and adaptive mechanisms, thus, leading to decreased levels of dopamine, serotonin, and their metabolites in most brain regions studied. These animals are also characterized by increased seizure readiness, which is not usually found in the postictal period in rats without heart pathologies. Hence, CHF prolongs the postictal changes in the brain, limits its capacity to recovery, which, in turn, builds a basis for further seizure development.


monoamines chronic heart failure brain seizures 


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© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  1. 1.Moscow State Pedagogical UniversityMoscowRussia
  2. 2.MoscowRussia

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