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Monoamine metabolism in the brain of rats with chronic heart failure of non-ischemic origin

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Abstract

Chronic heart failure (CHF) modulates the activity of monoaminergic systems in the central nervous system (CNS). An increased dioxyphenylacetic acid/dopamine ratio and 5-oxyindoleacetic acid/serotonin ratio in the majority of the brain structures studied during CHF indicate the high activity of the dopamine and serotonin systems and their functional stress during the development of hypoxia-compensative processes aimed at the maintenance of the normal cerebral blood flow. However, if a convulsive seizure develops during CHF, it may result in the failure of compensatory and adaptive mechanisms, thus, leading to decreased levels of dopamine, serotonin, and their metabolites in most brain regions studied. These animals are also characterized by increased seizure readiness, which is not usually found in the postictal period in rats without heart pathologies. Hence, CHF prolongs the postictal changes in the brain, limits its capacity to recovery, which, in turn, builds a basis for further seizure development.

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References

  1. Halaris, A., Int. Angiol., 2009, vol. 28, no. 2, pp. 92–99.

    PubMed  CAS  Google Scholar 

  2. Fonyakin, A.V. and Geraskina, L.A., Atmosfera. Nervnye Bolezni, 2005, no. 2, pp. 2–7.

  3. Simonenko, V.B. and Shirokov, E.A., Osnovy kardionevrologii (Rukovodstvo dlya vrachei) (Basic Cardioneurology, a Manual for Physicians), Moscow: Meditsina, 2001.

    Google Scholar 

  4. Kadykov, A.S., Manvelov, L.S., and Shakhparonova, N.V., Khronicheskie sosudistye zabolevaniya golovnogo mozga (distsirkulyatornaya entsefalopatiya) (Chronic Vascular Diseases of the Brain: Dyscirculatory Encephalopathy), Moscow: GEOTAR-Media, 2006.

    Google Scholar 

  5. Gulyaeva, N.V., Neirokhimiya, 2010, vol. 27, no. 2, pp. 102–108.

    Google Scholar 

  6. Clancy, R.R., Sharif, U., Ichord, R., Spray, T.L., Nicolson, S., Tabbutt, S., Wernovsky, G., and Gaynor, J.W., Epilepsia, 2005, vol. 46, no. 1, pp. 84–90.

    Article  PubMed  Google Scholar 

  7. Nilsen, K.B., Haram, M., Tangedal, S., Sandab, T., and Brodtkorb, E., Seizure, 2010, vol. 19, no. 3, pp. 291–295.

    Article  PubMed  Google Scholar 

  8. Semiokhina, A.F., Fedotova, I.B., and Poletaeva, I.I., Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 2006, vol. 56, no. 3, pp. 298–316.

    CAS  Google Scholar 

  9. Pintor, M., Mefford, I.N., Hutter, I.., Pocotte, S.L., Wyler, A.R., and Nadi, N.S., Synapse, 1990, vol. 5, no. 2, pp. 152–156.

    Article  PubMed  CAS  Google Scholar 

  10. Fedorov, V.N., Yartsev, A.V., and Danilova, O.V., Patol. Fiziol. Eksp. Ter., 2005, no. 3, pp. 7–9.

  11. Fedorov, V.N., Nozdrachev, A.D., Sal’nikov, E.V., Sidorov, A.V., Yartsev, A.V., and Fateev, M.M., Vestn. SPbGU, Ser. 3., 2006, no. 2, pp. 103–107.

  12. Mezhdunarodnye rekomendatsii po provedeniyu mediko-biologicheskikh issledovanii s ispol’zovaniem zhivotnykh, Lanimalogiya, 1993, no. 1, pp. 29–32.

  13. Browning, R.A. and Mayeenert, E.W., Eur. J. Pharmacol., 1978, vol. 50, no. 5, pp. 91–101.

    Google Scholar 

  14. Bourne, W.M., Chin, L., and Picchioni, A.L., J. Pharmacol., 1972, vol. 24, no. 12, pp. 913–914.

    Article  Google Scholar 

  15. Montepietra, S., Cattaneo, L., and Granella, F., Seizure, 2009, vol. 18, no. 5, pp. 379–381.

    Article  PubMed  Google Scholar 

  16. Tigaran, S., Mølgaard, H., McClelland, R., Dam, M., and Jaffe, A.S., Neurology, 2003, vol. 60, no. 3, pp. 492–495.

    PubMed  CAS  Google Scholar 

  17. Chazov, E.I. and Kalenikova, E.I., Dokl. Akad. Nauk, 1996, vol. 348, no. 4, pp. 570–572.

    PubMed  CAS  Google Scholar 

  18. Nissenbaum, L.K. and Zigmondt, M.T., Swed A.F., Abercrombie E.D, J. Neurosci., 1991, vol. 11, no. 5, pp. 1478–1484.

    Google Scholar 

  19. Bjönkman, S.T., Miller, S.M., Rose, S.E., Wallis, L.E.D., Burke, C., Stevenson, N.J., and Colditz, P.B., Neurosci., 2010, vol. 166, no. 1, pp. 157–167.

    Article  Google Scholar 

  20. Sanchez, R.M. and Jensen, F.E., Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period Models of Seizures and Epilepsy, United States: Academic Press, 2006, pp. 323–331.

    Google Scholar 

  21. Freund, T.E., Vlinen, A., and Miettinen, P., Brain Res. Bull, 1992, vol. 28, no. 1, pp. 27–38.

    Article  PubMed  CAS  Google Scholar 

  22. Bertram, G., Kattsung, in Bazisnaya i klinicheskaya farmakologiya (Basic and Clinical Pharmacology), Moscow: Binom, 2007, vol. 2.

    Google Scholar 

  23. Bazyan, A.S., Zhulin, V.V., Karpova, M.N., Klishina, N.Yu., and Glebov, R.N., Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 1998, vol. 48, no. 1, pp. 135–142.

    CAS  Google Scholar 

  24. Psarropoulou, C., Matsokis, N., Angelatou, F., and Kostopoulos, G., Epilepsia, 1994, vol. 35, no. 2, pp. 12–17.

    Article  PubMed  CAS  Google Scholar 

  25. Mainardi, P., Leonardi, A., and Albano, C., Medical Hypotheses, 2008, vol. 70, no. 4, pp. 876–879.

    Article  PubMed  CAS  Google Scholar 

  26. Kryzhanovskii, G.N., Zhurn. Nevrol. i Psikhiatrii, 2002, no. 11, pp. 4–13.

  27. Pshennikova, M.G., Ros. fiziol. zhurn. im. I.M. Sechenova, 2002, vol. 88, no. 4, pp. 485–495.

    CAS  Google Scholar 

  28. Pshennikova, M.G., Popkova, E.V., and Shimkovich, M.V., Usp. Fiziol. Nauk, 2003, vol. 34, no. 3, pp. 55–67.

    PubMed  CAS  Google Scholar 

  29. Markus, C.R., Neuromolecular. Med., 2008, vol. 10, no. 4, pp. 247–258.

    Article  PubMed  CAS  Google Scholar 

  30. Idova, G.V., Cheido, M.A., and Devoino, L.V., Dokl. Biol. Sci., 2004, vol. 398, pp. 351–353.

    Article  PubMed  CAS  Google Scholar 

  31. Perveen, T., Zehra, S.F., and Haider, S., Pak. J. Pharm. Sci., 2003, vol. 16, no. 1, pp. 27–33.

    PubMed  CAS  Google Scholar 

  32. Briones-Aranda, A., Rocha, L., and Picazo, O., Progr. Neuro-Psychopharmacol. Biolog. Psychiatry, 2005, vol. 29, no. 3, pp. 275–281.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Moscow State Pedagogical University, Moscow, Russia

    M. L. Mamalyga

  2. ul. Kibal’chicha 6, korp. 4, Moscow, 129278, Russia

    M. L. Mamalyga

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  1. M. L. Mamalyga
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Correspondence to M. L. Mamalyga.

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Original Russian Text © M.L. Mamalyga, 2012, published in Neirokhimiya, 2012, Vol. 29, No. 1, pp. 45–51.

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Mamalyga, M.L. Monoamine metabolism in the brain of rats with chronic heart failure of non-ischemic origin. Neurochem. J. 6, 38–43 (2012). https://doi.org/10.1134/S1819712411040118

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