Neurochemical Journal

, Volume 6, Issue 1, pp 38–43 | Cite as

Monoamine metabolism in the brain of rats with chronic heart failure of non-ischemic origin

Experimental Articles

Abstract

Chronic heart failure (CHF) modulates the activity of monoaminergic systems in the central nervous system (CNS). An increased dioxyphenylacetic acid/dopamine ratio and 5-oxyindoleacetic acid/serotonin ratio in the majority of the brain structures studied during CHF indicate the high activity of the dopamine and serotonin systems and their functional stress during the development of hypoxia-compensative processes aimed at the maintenance of the normal cerebral blood flow. However, if a convulsive seizure develops during CHF, it may result in the failure of compensatory and adaptive mechanisms, thus, leading to decreased levels of dopamine, serotonin, and their metabolites in most brain regions studied. These animals are also characterized by increased seizure readiness, which is not usually found in the postictal period in rats without heart pathologies. Hence, CHF prolongs the postictal changes in the brain, limits its capacity to recovery, which, in turn, builds a basis for further seizure development.

Keywords

monoamines chronic heart failure brain seizures 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Halaris, A., Int. Angiol., 2009, vol. 28, no. 2, pp. 92–99.PubMedGoogle Scholar
  2. 2.
    Fonyakin, A.V. and Geraskina, L.A., Atmosfera. Nervnye Bolezni, 2005, no. 2, pp. 2–7.Google Scholar
  3. 3.
    Simonenko, V.B. and Shirokov, E.A., Osnovy kardionevrologii (Rukovodstvo dlya vrachei) (Basic Cardioneurology, a Manual for Physicians), Moscow: Meditsina, 2001.Google Scholar
  4. 4.
    Kadykov, A.S., Manvelov, L.S., and Shakhparonova, N.V., Khronicheskie sosudistye zabolevaniya golovnogo mozga (distsirkulyatornaya entsefalopatiya) (Chronic Vascular Diseases of the Brain: Dyscirculatory Encephalopathy), Moscow: GEOTAR-Media, 2006.Google Scholar
  5. 5.
    Gulyaeva, N.V., Neirokhimiya, 2010, vol. 27, no. 2, pp. 102–108.Google Scholar
  6. 6.
    Clancy, R.R., Sharif, U., Ichord, R., Spray, T.L., Nicolson, S., Tabbutt, S., Wernovsky, G., and Gaynor, J.W., Epilepsia, 2005, vol. 46, no. 1, pp. 84–90.PubMedCrossRefGoogle Scholar
  7. 7.
    Nilsen, K.B., Haram, M., Tangedal, S., Sandab, T., and Brodtkorb, E., Seizure, 2010, vol. 19, no. 3, pp. 291–295.PubMedCrossRefGoogle Scholar
  8. 8.
    Semiokhina, A.F., Fedotova, I.B., and Poletaeva, I.I., Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 2006, vol. 56, no. 3, pp. 298–316.Google Scholar
  9. 9.
    Pintor, M., Mefford, I.N., Hutter, I.., Pocotte, S.L., Wyler, A.R., and Nadi, N.S., Synapse, 1990, vol. 5, no. 2, pp. 152–156.PubMedCrossRefGoogle Scholar
  10. 10.
    Fedorov, V.N., Yartsev, A.V., and Danilova, O.V., Patol. Fiziol. Eksp. Ter., 2005, no. 3, pp. 7–9.Google Scholar
  11. 11.
    Fedorov, V.N., Nozdrachev, A.D., Sal’nikov, E.V., Sidorov, A.V., Yartsev, A.V., and Fateev, M.M., Vestn. SPbGU, Ser. 3., 2006, no. 2, pp. 103–107.Google Scholar
  12. 12.
    Mezhdunarodnye rekomendatsii po provedeniyu mediko-biologicheskikh issledovanii s ispol’zovaniem zhivotnykh, Lanimalogiya, 1993, no. 1, pp. 29–32.Google Scholar
  13. 13.
    Browning, R.A. and Mayeenert, E.W., Eur. J. Pharmacol., 1978, vol. 50, no. 5, pp. 91–101.Google Scholar
  14. 14.
    Bourne, W.M., Chin, L., and Picchioni, A.L., J. Pharmacol., 1972, vol. 24, no. 12, pp. 913–914.CrossRefGoogle Scholar
  15. 15.
    Montepietra, S., Cattaneo, L., and Granella, F., Seizure, 2009, vol. 18, no. 5, pp. 379–381.PubMedCrossRefGoogle Scholar
  16. 16.
    Tigaran, S., Mølgaard, H., McClelland, R., Dam, M., and Jaffe, A.S., Neurology, 2003, vol. 60, no. 3, pp. 492–495.PubMedGoogle Scholar
  17. 17.
    Chazov, E.I. and Kalenikova, E.I., Dokl. Akad. Nauk, 1996, vol. 348, no. 4, pp. 570–572.PubMedGoogle Scholar
  18. 18.
    Nissenbaum, L.K. and Zigmondt, M.T., Swed A.F., Abercrombie E.D, J. Neurosci., 1991, vol. 11, no. 5, pp. 1478–1484.Google Scholar
  19. 19.
    Bjönkman, S.T., Miller, S.M., Rose, S.E., Wallis, L.E.D., Burke, C., Stevenson, N.J., and Colditz, P.B., Neurosci., 2010, vol. 166, no. 1, pp. 157–167.CrossRefGoogle Scholar
  20. 20.
    Sanchez, R.M. and Jensen, F.E., Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period Models of Seizures and Epilepsy, United States: Academic Press, 2006, pp. 323–331.Google Scholar
  21. 21.
    Freund, T.E., Vlinen, A., and Miettinen, P., Brain Res. Bull, 1992, vol. 28, no. 1, pp. 27–38.PubMedCrossRefGoogle Scholar
  22. 22.
    Bertram, G., Kattsung, in Bazisnaya i klinicheskaya farmakologiya (Basic and Clinical Pharmacology), Moscow: Binom, 2007, vol. 2.Google Scholar
  23. 23.
    Bazyan, A.S., Zhulin, V.V., Karpova, M.N., Klishina, N.Yu., and Glebov, R.N., Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 1998, vol. 48, no. 1, pp. 135–142.Google Scholar
  24. 24.
    Psarropoulou, C., Matsokis, N., Angelatou, F., and Kostopoulos, G., Epilepsia, 1994, vol. 35, no. 2, pp. 12–17.PubMedCrossRefGoogle Scholar
  25. 25.
    Mainardi, P., Leonardi, A., and Albano, C., Medical Hypotheses, 2008, vol. 70, no. 4, pp. 876–879.PubMedCrossRefGoogle Scholar
  26. 26.
    Kryzhanovskii, G.N., Zhurn. Nevrol. i Psikhiatrii, 2002, no. 11, pp. 4–13.Google Scholar
  27. 27.
    Pshennikova, M.G., Ros. fiziol. zhurn. im. I.M. Sechenova, 2002, vol. 88, no. 4, pp. 485–495.Google Scholar
  28. 28.
    Pshennikova, M.G., Popkova, E.V., and Shimkovich, M.V., Usp. Fiziol. Nauk, 2003, vol. 34, no. 3, pp. 55–67.PubMedGoogle Scholar
  29. 29.
    Markus, C.R., Neuromolecular. Med., 2008, vol. 10, no. 4, pp. 247–258.PubMedCrossRefGoogle Scholar
  30. 30.
    Idova, G.V., Cheido, M.A., and Devoino, L.V., Dokl. Biol. Sci., 2004, vol. 398, pp. 351–353.PubMedCrossRefGoogle Scholar
  31. 31.
    Perveen, T., Zehra, S.F., and Haider, S., Pak. J. Pharm. Sci., 2003, vol. 16, no. 1, pp. 27–33.PubMedGoogle Scholar
  32. 32.
    Briones-Aranda, A., Rocha, L., and Picazo, O., Progr. Neuro-Psychopharmacol. Biolog. Psychiatry, 2005, vol. 29, no. 3, pp. 275–281.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  1. 1.Moscow State Pedagogical UniversityMoscowRussia
  2. 2.MoscowRussia

Personalised recommendations