Neurochemical Journal

, 5:138 | Cite as

Activation of monoamine oxidase as a compensatory response during ischemic insult

  • M. G. Uzbekov
  • V. V. Alferova
  • E. Yu. Misionzhnik
  • A. B. Gekht
Clinical Neurochemistry


We measured the activity of monoamine oxidase (MAO) in platelets taken from 25 patients in the acute period of ischemic hemispheric insult. The neurological deficit of the patients on arrival and discharge from the hospital was evaluated using the data from clinical examinations and tests. In 64% of the patients with ischemic insult, we found a considerable increase in the activity of platelet MAO on the 3rd–5th day of the insult, as compared to the control group (P < 0.001). We found a correlation between the increase in MAO activity on the 3rd–5th day after ischemic insult and a decrease in neurological deficit on the 21st day after the insult. The increase in the MAO activity during the acute period of ischemic insult is, presumably, one of compensatory responses that develop during insult.


monoamine oxidase of platelets acute period of ischemic insult neurological deficit compensatory response 


  1. 1.
    Gusev, E. I. and Skvortsova, V. I., Ishemiya golovnogo mozga (Brain Ischemia), Moscow: Meditsina, 2001.Google Scholar
  2. 2.
    Chen, K., J. Neurotoxicol., 2004, vol. 25, pp. 31–36.CrossRefGoogle Scholar
  3. 3.
    Holschneider, P., Scremin, O.U., Huynh, L., Chen, H., and Shih, J. C., Neurosci., 1999, vol. 3, pp. 161–164.Google Scholar
  4. 4.
    Maher, P. and Davis, J. B., J. Neurosci., 1996, vol. 20, pp. 6394–6401.Google Scholar
  5. 5.
    Shaheen, A.A., Abd-el-Fattah, A.A., and Seif-el-Nasr, M., Arzneimittelforschung, 2008, vol. 58, no. 4, pp. 160–167.Google Scholar
  6. 6.
    Stahl, S.M., Psychopharmacol. Bul., 1985, vol. 21, pp. 663–671.Google Scholar
  7. 7.
    Brott, T.G., Stroke, 1992, vol. 23, pp. 632–640.PubMedGoogle Scholar
  8. 8.
    Frankel, M. R., Neurology, 2000, vol. 55, pp. 952–959.PubMedGoogle Scholar
  9. 9.
    Mahoney, F. and Barthel, D., MD State Med. J., 1965, vol. 14, pp. 61–65.PubMedGoogle Scholar
  10. 10.
    Voloshina, O.N. and Moskvitina, T.A., Lab. Delo, 1985, no. 5, pp. 289–291.Google Scholar
  11. 11.
    Uzbekov, M.G. and Misionzhnik, E.Yu., Ros. Psikhiatr. Zh., 2000, no. 4, pp. 56–65.Google Scholar
  12. 12.
    Uzbekov, M.G., Misionzhnik, E.Yu., Shmukler, A.B., Gurovich, I. Ya., Gryzunov, Yu.A., Smolina, N.V., Kalinina, V.V., Sokolova, T.N., Moskvitina, T.A., and Shevchenko, V.A., Zhurn. Nevr. i Psikhiatr., 2009, no. 5, pp. 48–52.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • M. G. Uzbekov
    • 1
    • 3
  • V. V. Alferova
    • 2
  • E. Yu. Misionzhnik
    • 1
  • A. B. Gekht
    • 2
  1. 1.Moscow Institute of PsychiatryMoscowRussia
  2. 2.Department of Neurology and NeurosurgeryRussian State Medical UniversityMoscowRussia
  3. 3.MoscowRussia

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