Neurochemical Journal

, Volume 4, Issue 4, pp 304–313 | Cite as

Effects of stimulation of the hypothalamic nuclei and treatment with a proline-rich peptide on neurons of the superior vestibular nuclei during exposure to vibration

  • S. H. Sarkisyan
  • V. A. Chavushyan
  • I. B. Meliksetyan
  • V. S. Kamenecki
  • S. M. Minasyan
  • J. S. Sarkissian
  • A. A. Galoyan
Experimental Articles

Abstract

Vibration impairs functioning of the nervous, cardiovascular, and motor systems. Postvibration disturbances in vestibular function are determined by adaptive changes in neuromediatory processes. We studied the possibility of the regulation of the CNS functions by neurohumoral factors, viz., hypothalamic proline-rich peptides (PRP). We found changes in the spiking activity of single neurons of the superior vestibular nucleus (SVN) in response to high-frequency stimulation (HFS) of the paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus in the presence of vibration or systemic treatment with PRP-1. Mathematical analysis of impulse activity showed predominantly tetanic potentiation (TP) in the SVN neurons in response to HFS. Vibration resulted in a decrease in the TP level and an increase in the post-tetanic potentiation. The results of the morphological and histochemical analyses suggest a close relationship between neurons and gliocytes, with both being involved in integral unit formation. An enhanced level of survival of SVN neurons and activation of acidic phosphatase in SVN were also found in the presence of PRP during long-term exposure to vibration.

Keywords

superior vestibular nucleus vibration action single neuronal activity tetanic stimulation, hypothalamic supraoptical and paraventricular nuclei proline rich peptide 

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • S. H. Sarkisyan
    • 1
    • 4
  • V. A. Chavushyan
    • 2
  • I. B. Meliksetyan
    • 2
  • V. S. Kamenecki
    • 2
  • S. M. Minasyan
    • 1
  • J. S. Sarkissian
    • 2
  • A. A. Galoyan
    • 3
  1. 1.Yerevan State UniversityYerevanArmenia
  2. 2.Orbeli Institute of PhysiologyNational Academy of SciencesYerevanArmenia
  3. 3.Buniatian Institute of BiochemistryNational Academy of SciencesYerevanArmenia
  4. 4.YerevanArmenia

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