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Neurochemical Journal

, 3:297 | Cite as

Effects of biguanides on oxidative status of rat tissues after cerebral ischemia/reperfusion

  • O. A. Safonova
  • T. N. Popova
  • A. V. Makeeva
  • L. F. Panchenko
Experimental Articles

Abstract

We studied the effects of synthetic biguanide derivatives on the intensity of free-radical processes and catalase activity in rat tissues after cerebral ischemia/reperfusion. We found that administration of phenylethyl-biguanide or (2,4-dimethoxyphenyl)biguanide in this pathology decreased the lactate/pyruvate ratio, an index of cell metabolism impairment, as compared to this index in rats with pathology. In the brain of rats and their blood serum, we observed a decrease in biochemiluminescence parameters, which was enhanced after ischemia/reperfusion and reflected the intensity of free radical processes. We also found a decrease in the mobilization rate of the antioxidant system as compared to the rate observed after pathology. These data show that the biguanide derivatives studied had antioxidant and protective properties in ischemic brain damage accompanied by oxidative stress.

Key words

biguanides cerebral ischemia/reperfusion rats free radical oxidation biochemiluminescence catalase 

Abbreviations

FRO

free radical oxidation

AOS

antioxidant system

ROS

reactive oxygen species

CIR

cerebral ischemia/reperfusion

LPO

lipid peroxidation

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Copyright information

© MAIK Nauka 2009

Authors and Affiliations

  • O. A. Safonova
    • 1
    • 3
  • T. N. Popova
    • 1
  • A. V. Makeeva
    • 1
  • L. F. Panchenko
    • 2
  1. 1.Voronezh State UniversityVoronezhRussia
  2. 2.Institute of General Pathology and PathophysiologyRussian Academy of Medical SciencesMoscowRussia
  3. 3.VoronezhRussia

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