Abstract
We performed a mathematical analysis of the dependence of the final concentration of ATP in the brain tissue of animals on the activity of oxidative mitochondrial enzymes. We constructed a mathematical model that approximates this relationship under different conditions of the body’s vital activity. The model proposed helps to calculate and predict the energetic state of the brain during mitochondrial dysfunction of the respiratory chain induced by hypoxias of different severities.
Similar content being viewed by others
References
Luk’yanova, L.D., Mitokhondrial’naya disfunktsiya — tipovoi patologicheskii protsess, molekulyarnyi mekhanizm gipoksii, in “Problemy gipoksii: molekulyarnye, fiziologicheskie i meditsinskie aspekty” (Problems of Hypoxia: Molecular, Physiological and Medical Aspects), Moscow, 2004, pp. 8–50.
Dudchenko, A.M. and Luk’yanova, L.D., Triggernaya rol’ energeticheskogo obmena v kaskade funktsional’no metabolicheskikh narushenii pri gipoksii, in “Problemy gipoksii: molekulyarnye, fiziologicheskie i meditsinskie aspekty” (Problems of Hypoxia: Molecular, Physiological and Medical Aspects), Moscow, 2004, pp. 51–83.
Moshkova, A.N., Khvatova, E.M., and Rusakova, I.A., Neurochem. J., 2007, no. 3, pp. 240–243.
Bergmeyer, H.V., Meth. Enzym. Anal., 1974, vol. 6, p. 2127.
Bergmeyer, H.V., Meth. Enzym. Anal., 1984, vol. 6, p. 582.
Moshkova, A.N., Stefanov, V.E., Khvatova, E.M., and Lyzlova, S.N., Byull. Eksp. Biol. Med., 1998, vol. 125, no. 4, pp. 391–394.
Eshchenko, N.D., in Metody biokhimicheskikh issledovanii (Methods of Biochemical Studies), Leningrad: Leningr. Gos. Univ., 1982, pp. 29–32.
Lowry, O., Rosebrough, N., Farr, A., and Raudall, R.J., J. Biol. Chem., 1951, vol. 193, pp. 265–275.
Gulidova, G.N. and Sorokina, I.N., Byull. Eksp. Biol. Med., 1967, vol. 63, no. 1, pp. 41–44.
Ivanova, T.V. and Rubel’, L.N., Evolyuts. Biokhim. Fiziol., 1969, vol. 5, pp. 279–287.
Praktikum po biokhimii (Training Biochemistry) Severin, S.E. and Solov’eva, G.A., Eds., Moscow: Mosk. Gos. Univ., 1989, p. 190.
Aivazyan, S.A., Enyukov, I.S., and Meshalkin, L.D., Prikladnaya Statistika: Issledovanie Zavisimostei (Applied Statistics: Dependence Analysis), Moscow: Finansy i Statistika, 1985.
Semenova, T.S., Rubanova, N.A., and Fokin, V.M., Fermentativnaya kharakteristika mozga pri raznykh patogeneticheskikh formakh gipoksii, in “Biokhimiya gipoksii, trudy Gor’kovskogo meditsinskogo instituta im. S.M. Kirova” (Biochemistry of Hypoxia, Works of Gorky Medical Institute), Gorky, 1975, vol. 63, pp. 65–70.
Moshkova, A.N., Khvatova, E.M., and Rusakova, I.A., Neirokhimiya, 2004, vol. 21, no. 2, pp. 121–124.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © A.N. Moshkova, E.M. Khvatova, I.A. Rusakova, 2009, published in Neirokhimiya, 2009, Vol. 26, No. 1, pp. 51–55.
Rights and permissions
About this article
Cite this article
Moshkova, A.N., Khvatova, E.M. & Rusakova, I.A. Analysis and prediction of ATP concentration in the animal brain under hypoxic conditions. Neurochem. J. 3, 44–48 (2009). https://doi.org/10.1134/S1819712409010061
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1819712409010061