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Neurochemical Journal

, Volume 1, Issue 4, pp 275–280 | Cite as

Synaptic and extrasynaptic NMDA receptors: Problems and prospects

Review Articles
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Abstract

This review is devoted to the problem of induction of differently directed NMDA-dependent longterm plasticity in the central nervous system and their transformation into pathological changes. Their hypothetical mechanisms and the corresponding experimental data are discussed. Special attention is paid to the functional characteristics of synaptic and extrasynaptic NR1/NR2A and NR1/NR2B receptors, their different involvement in the spatiotemporal organization of Ca2+ signaling, and peculiarities of biochemical reactions of the cell. The possible structural reorganization of NMDA receptors as one of the kinds of plasticity is also analyzed.

Key words

synaptic NMDA receptors extrasynaptic NMDA receptors NR2A subunit NR2B subunit plasticity neuropathology 

Abbreviations

EPSC

excitatory postsynaptic current

LPD

long-term depression

LPT

long-term potentiation

NMDA

N-methyl-D-aspartate

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© Pleiades Publishing, Ltd. 2007

Authors and Affiliations

  1. 1.Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscowRussia

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