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The neurochemistry of the psychological dependence syndrome in addictive diseases of chemical etiology

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Abstract

The syndrome of psychological dependence on psychoactive substances (SPD) is the most important element in the pathogenesis of the addictive diseases (narcoticism and alcoholism). Studies of this syndrome are possible on the basis of the achievements of a number of sciences including neurobiology, neurochemistry, physiology, and psychology. In recent years, changes in signal transduction systems occurring during the chronic action of psychoactive substances have been investigated in detail. It is believed that such disorders are involved in the development of the SPD. These problems are discussed in connection with the prophylaxis and treatment of addictive diseases.

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Abbreviations

CRF:

corticotrophin releasing factor

DA:

dopamine

EAA:

exitatory amino acids

PAS:

psychoactive substances

SPD:

syndrome of psychological dependence

References

  1. Val’dman, A.V., Babayan, E.A., and Zvartau, E.E., Psikhofarmakologicheskie i medico-pravovye aspekty toksikomanii (Psycopharmacological and Medicojural Aspects of Toxicomanias), Moscow: Meditsina, 1988.

    Google Scholar 

  2. Sudakov, S.K. and Sudakov, K.V., Narkologiya, 2003, no. 1, pp. 38–43.

  3. Pyatnitskaya, I. N., Narkomanii: Rukovodstvo dlya vrachei (Drug Addictions: Handbook for Doctors), Moscow: Meditsina, 1994.

    Google Scholar 

  4. Shabalina, V. V., Psikhologiya zavisimogo povedeniya: Na primere povedeniya, svyazannogo s potrebleniem narkotikov i drugikh psikhoaktivnykh veshchestv (Psychology of Dependent Behavior: On the Example of Behavior Associated with Use of Narcotics and Other Psychoactive Substances), SPb: St. Petersburg University, 2004.

    Google Scholar 

  5. Zvartau, E.E., Metodologya izucheniya narkotoksikomanii (Methodology of Studies of Narcotoxicomanias), Itogi nauki i tekhniki, VINITI, ser. Narcology, 1988, vol. 1.

  6. Cami, J., Farre, M., New Engl. J. Med., 2003, vol. 349, no. 10, pp. 975–986.

    Article  PubMed  CAS  Google Scholar 

  7. Entsiklopedia medizinskikh terminov (Encyclopedia of Medical Terms), Petrovskii, B.V., Ed., Moscow: Sovetskaya Entsyklopediya, 1984, vol. 3.

    Google Scholar 

  8. Sudakov, K.V., Zh. Nevrologii i Psikhiatrii im. Korsakova, S.S., 2000, vol. 100, no. 10, pp. 7–17.

    CAS  Google Scholar 

  9. Slovar’fisiologicheskikh terminov (Dictionary of Physiological Terms), Gazenko, O.G., Ed., Moscow: Nauka, 1987.

    Google Scholar 

  10. Lichko, A.E. and Bitenskii, V.S., Podrostkovaya narkomaniya: Rukovodstvo (Adolescent Narcotism: Handbook), Leningrad: Meditsina, 1991.

    Google Scholar 

  11. Sudakov, K.V., Vestn. Ross. Akad. Med. Nauk, 2001, no. 4, pp. 3–12.

  12. Sudakov, K.V., Vestn. Ross. Akad. Med. Nauk, 1997, no. 12, pp. 52–56.

  13. Ykhtomskii, A.A., Dominanta, Moscow-Leningrad: Nauka, 1966.

    Google Scholar 

  14. Shabanov, P.D., Nozdrachev, A.D., Lebedev, A.A., and Lebedev, V.A., Ros. Fisiol. Zh. im. Sechenova, I.M., 2000, vol. 86, no. 8, pp. 935–945.

    CAS  Google Scholar 

  15. Koob, G.F. and Bloom, F.E., Science, 1988, vol. 242, no. 4879, pp. 715–723.

    Article  PubMed  CAS  Google Scholar 

  16. Koob, G.F. and Le Moal, M., Neuropsychopharmacology. 2001, vol. 24, no. 2, pp. 97–129.

    Article  PubMed  CAS  Google Scholar 

  17. Bozarth, M.A. and Wise, R.A., Prog. Neuropsychopharmacol. Biol. Psychiatry, 1983, vol. 7, no. 4–6, pp. 569–575.

    Article  PubMed  CAS  Google Scholar 

  18. Wise, R.A. and Bozarth, M.A., Psychiatr. Med., 1985, vol. 3, no. 4, pp. 445–460.

    PubMed  CAS  Google Scholar 

  19. Robinson, T.E. and Berridge, K.C., Annu. Rev. Psychol., 2003, vol. 54, pp. 25–53.

    Article  PubMed  Google Scholar 

  20. Van Ree, J.M., Gerrits, M.A.F.M., Vanderschuren, L.J.M.J., Pharmacol. Rev., 1999, vol. 51, no. 2, pp. 341–396.

    PubMed  Google Scholar 

  21. White, F.J., J. Neurosci., 2002, vol. 22, no. 9, pp. 3303–3305.

    PubMed  CAS  Google Scholar 

  22. Golikov, S.N., Sanotskii, I.V., and Tiunov, L.A., Obshchie mekhanismy toksicheskogo deistviya (General Mechanisms of Toxic Action), Leningrad: Meditsyna, 1986.

    Google Scholar 

  23. Agatsuma, S. and Hiroi, N., Nihon Shinkei Seishin Yakurigaku Zasshi, 2004, vol. 24, no. 3, pp. 137–145 (Articlein Japanese).

    PubMed  CAS  Google Scholar 

  24. Beitner-Johnson, D., Guitart, X., and Nestler, E.J. Brain Res., 1991, vol. 561, no. 1, pp. 147–150.

    Article  PubMed  CAS  Google Scholar 

  25. Guitart, X., Beitner-Johnson, D., Marby, D.W., et al., Synapse, 1992, vol. 12, no. 3, pp. 242–253.

    Article  PubMed  CAS  Google Scholar 

  26. Anokhina, I.P., Veretinskaya, A.G., and Vekshina, N.L., Vopr. Narkologii, 2003, no. 6, pp. 62–68.

  27. Anokhina, I.P., Ivanets, N.N., Shamakina, I.Yu., et al., Nrkologiya, 2004, no. 6, pp. 71–77.

  28. Lektsyi po narkologii (Lectures on Narcology), Ivanets, N.N., Ed., Moscow: Nolidzh, 2000.

    Google Scholar 

  29. Bardo, M.T. Crit. Rev. Neurobiol., 1998, vol. 12, no. 1–2, pp. 37–67.

    PubMed  CAS  Google Scholar 

  30. De Vries, T.J. and Shippenberg, T.S., J. Neurosci., 2002, vol. 22, no. 9, pp. 3321–3325.

    PubMed  Google Scholar 

  31. Rocha, B.A., Scearce-Levie, K., Lucas, J.J., et al., Nature, 1998, vol. 393, no. 6681, pp. 175–178.

    Article  PubMed  CAS  Google Scholar 

  32. Acquas, E. and Di Chiara, G. J. Neurochem., 1992, vol. 58, no. 5, pp. 1620–1625.

    Article  PubMed  CAS  Google Scholar 

  33. Fuentealba, J.A., Forray, M.I., Gysling, K., J. Neurochem., 2000, vol. 75, no. 2, pp. 741–748.

    Article  PubMed  CAS  Google Scholar 

  34. Moises, H.C. and Smith, C.B., Brain Res., 1987, vol. 400, no. 1, pp. 110–126.

    Article  PubMed  CAS  Google Scholar 

  35. Tjon, G.H., De Vries, T.J., Ronken, E., et al., Eur. J. Pharmacol., 1994, vol. 252, no. 2, pp. 205–212.

    Article  PubMed  CAS  Google Scholar 

  36. Turchan, J., Lason, W., Budziszewska, B., and Przewlocka, B., Neuropeptides, 1997, vol. 31, no. 1, pp. 24–28.

    Article  PubMed  CAS  Google Scholar 

  37. Shalev, U., Grimm, J.W., and Shaham, Y., Pharmacol. Rev., 2002, vol. 54, no. 1. pp. 1–42.

    Article  PubMed  CAS  Google Scholar 

  38. Salamone, J.D. and Correa, M., Behav. Brain Res., 2002, vol. 137, no. 1–2, pp. 3–25.

    Article  PubMed  CAS  Google Scholar 

  39. Bosse, A. and Kuschinsky, K., Naunyn-Schmiedeberg’s Arch. Pharmacol., 1976, vol. 294, no. 1, pp. 17–22.

    Article  CAS  Google Scholar 

  40. Diana, M., Muntoni, A.L., Pistis, M., et al., Eur. J. Neurosci., 1999, vol. 11, no. 3, pp. 1037–1041.

    Article  PubMed  CAS  Google Scholar 

  41. Diana, M., Pistis, M., Muntoni, A., and Gessa, G., J. Pharmacol. Exp. Ther., 1995, vol. 272, no. 2, pp. 781–785.

    PubMed  CAS  Google Scholar 

  42. Honkanen, A., Piepponen, T.P., and Ahtee, L., Neurosci. Lett., 1994, vol. 180, no. 2, pp. 119–122.

    Article  PubMed  CAS  Google Scholar 

  43. Lee, J.M., DeLeon-Jones, F., Fields, J.Z., and Ritzmann, R.F., Alcohol. Drug. Res., 1987, vol. 7, no. 1, pp. 1–10.

    PubMed  Google Scholar 

  44. Martin, J.R. and Takemori, A.E., Eur. J. Pharmacol., 1986, vol. 121, no. 2, pp. 221–229.

    Article  PubMed  CAS  Google Scholar 

  45. Casas, M., Guardia, J., Prat, G., and Trujols, J., Addiction, 1995, vol. 90, no. 6, pp. 831–835.

    Article  PubMed  CAS  Google Scholar 

  46. Stinus, L., Nadaud, D., Deminiere, J.M., et al., Biol. Psychiatry, 1989, vol. 26, no. 4, pp. 363–371.

    Article  PubMed  CAS  Google Scholar 

  47. Kozlov, A.A., Rokhlina, M.L., Chistyakova, L.A., and Ogar’, D.V., Narkologiya, 2004, no. 8, pp. 50–58.

  48. Spielewoy, C., Gonon, F., Roubert, C., et al., Eur. J. Neurosci., 2000, vol. 12, no. 5, pp. 1827–1837.

    Article  PubMed  CAS  Google Scholar 

  49. Noda, Y. and Nabeshima, T., Nippon Yakurigaku Zasshi, 2002, vol. 119, no. 4, pp. 213–217 (Article in Japanese).

    PubMed  CAS  Google Scholar 

  50. Noda, Y., Mamiya, T., and Nabeshima, T., NipponY-akurigaku Zasshi, 2001, vol. 117, no. 1, pp. 21–26 (Articlein Japanese).

    CAS  Google Scholar 

  51. Nakajima, S., Neurosci. Biobehav. Rev., 1989, vol. 13, no. 2–3, pp. 123–128.

    Article  PubMed  CAS  Google Scholar 

  52. Smith, J.W., Fetsko, L.A., Xu, R., and Wang, Y., Neuroscience, 2002, vol. 113, no. 4, pp. 755–765.

    Article  PubMed  CAS  Google Scholar 

  53. Walters, C.L. and Blendy, J.A., J. Neurosci., 2001, vol. 21, no. 23, pp. 9438–9444.

    PubMed  CAS  Google Scholar 

  54. Carlezon, W.A.Jr., Thome, J., and Olson, V.G., et al., Science, 1998, vol. 282, no. 5397, pp. 2272–2275.

    Article  PubMed  CAS  Google Scholar 

  55. Hiroi, N., Brown, J.R., Haile, C.N., et al., Proc. Natl. Acad. Sci., U. S. A., 1997, vol. 94, no. 19, pp. 10397–10402.

    Article  PubMed  CAS  Google Scholar 

  56. Bespalov, A.Yu. and Zvartau, E.E., Neiropsikhofarmacologiya antagonistov NMDA-retseptorov (Neuropcychofarmacology of Antagonists of the NMDA Receptors), SPb: Nevskii dialect, 2000.

    Google Scholar 

  57. Hummel, M. and Unterwald, E.M., J. Cell. Physiol., 2002, vol. 191, no. 1, pp. 17–27.

    Article  PubMed  CAS  Google Scholar 

  58. Haile, C.N., Hiroi, N., Nestler, E.J., and Kosten, T.A., Synapse, 2001, vol. 41, no. 3, pp. 179–190.

    Article  PubMed  CAS  Google Scholar 

  59. Nylander, I., Vlaskovska, M., and Terenius, L., Brain Res., 1995, vol. 683, no. 1, pp. 25–35.

    Article  PubMed  CAS  Google Scholar 

  60. Nabeshima, A., Toki, S., Saito, T., and Takahata, N., Nihon Shinkei Seishin Yakurigaku Zasshi, 1995, vol. 15, no. 4, pp. 345–353 (Article in Japanese).

    PubMed  CAS  Google Scholar 

  61. Werme, M., Thoren, P., Olson, L., and Brene, S., Eur. J. Neurosci., 2000, vol. 12, no. 8, pp. 2967–2974.

    Article  PubMed  CAS  Google Scholar 

  62. Werme, M., Olson, L., and Brene, S., Mol. Brain Res., 2000, vol. 76, no. 1, pp. 18–24.

    Article  PubMed  CAS  Google Scholar 

  63. Maldonado, R. and Rodriguez de Fonseca, F., J. Neurosci., 2002, vol. 22, no. 9, pp. 3326–3331.

    PubMed  CAS  Google Scholar 

  64. Anokhina, I.P., Lektsyi po narkologii (Lectures on Narcology), Ivanets, N.N., Ed., Moscow: Nolidzh, 2000, pp. 16–40.

    Google Scholar 

  65. Wang, G.J., Volkow, N.D., Fowler, J.S., et al., Neuropsychopharmacology, 1997, vol. 16, no. 2, pp. 174–182.

    Article  PubMed  CAS  Google Scholar 

  66. Wong, D.F., Maini, A., Rousset, O.G., and Brasic, J.R., Alcohol. Res. Health., 2003, vol. 27, no. 2, pp. 161–173.

    PubMed  Google Scholar 

  67. Kotler, M., Cohen, H., Segman, R., et al., Mol. Psychiatry, 1997, vol. 2, no. 3, pp. 251–254.

    Article  PubMed  CAS  Google Scholar 

  68. Li, T., Xu, K., Deng, H., et al., Mol. Psychiatry, 1997, vol. 2, no. 5, pp. 413–416.

    Article  PubMed  CAS  Google Scholar 

  69. Li, T., Liu, X., Zhao, J., et al., Am. J. Med. Genet., 2002, vol. 114, no. 3, pp. 329–335.

    Article  PubMed  Google Scholar 

  70. Gelernter, J., Kranzler, H., and Lacobelle, J., Genomics, 1998, vol. 52, no. 3, pp. 289–297.

    Article  PubMed  CAS  Google Scholar 

  71. Schuckit, M.A., Mazzanti, C., Smith T.L., et al., Biol. Psychiatry, 1999, vol. 45, no. 5, pp. 647–651.

    Article  PubMed  CAS  Google Scholar 

  72. Raevskii, K.S., and Georgiev, V.P., Mediatornye aminokisloty: neirofarmakologicheskie i neirokhimicheskie aspekty (Mediator Amino Acids: Neuropharmacological and neurochemical aspects), Moscow: Meditsyna, 1986.

    Google Scholar 

  73. Leshner, A.I. and Koob, G.F., Proc. Assoc. Am. Physicians, 1999, vol. 111, no. 2, pp. 99–108.

    Article  PubMed  CAS  Google Scholar 

  74. McBride, W.J., Murphy, J.M., and Ikemoto, S., Behav. Brain Res., 1999, vol. 101, no. 2, pp. 129–152.

    Article  PubMed  CAS  Google Scholar 

  75. Bespalov, A.Y., Balster, R.L., and Beardsley, P.M., J. Pharmacol. Exp. Ther., 1999, vol. 290, no. 1, pp. 20–27.

    PubMed  CAS  Google Scholar 

  76. Popik, P., Mamczarz, J., Fraczek, M., et al., Neuropharmacology, 1998, vol. 37, no. 8, pp. 1033–1042.

    Article  PubMed  CAS  Google Scholar 

  77. Hodge, C.W., Cox, A.A., and Bratt, A.M., Psychopharmacology (Berlin), 2001, vol. 154, no. 1, pp. 13–22.

    Article  CAS  Google Scholar 

  78. Watanabe, T., Nakagawa, T., Yamamoto, R., et al., Jpn. J. Pharmacol., 2002, vol. 88, no. 4, pp. 399–406.

    Article  PubMed  CAS  Google Scholar 

  79. Rasmussen, K., Neuropsychopharmacology, 1995, vol. 13, no. 4, pp. 295–300.

    Article  PubMed  CAS  Google Scholar 

  80. Belozertseva, I.V., Danysz, W., and Bespalov, A.Y., Naunyn-Schmiedeberg″s Arch. Pharmacol., 2000, vol. 361, no. 3, pp. 279–282.

    Article  CAS  Google Scholar 

  81. Zarrindast, M.R. and Mousa-Ahmadi, E., Eur. J. Pharmacol., 1999, vol. 381, no. 2–3, pp. 129–133.

    Article  PubMed  CAS  Google Scholar 

  82. Petrie, J., Sapp, D.W., Tyndale, R.F., et al., Alcohol. Clin. Exp. Res., 2001, vol. 25, no. 6, pp. 819–828.

    Article  PubMed  CAS  Google Scholar 

  83. Cummins, J.T., Sack, M., and von Hungen, K., Life Sci., 1990, vol. 47, no. 10, pp. 877–882.

    Article  PubMed  CAS  Google Scholar 

  84. Kang, M., Spigelman, I., Sapp, D.W., and Olsen, R.W., Brain Res., 1996, vol. 709, no. 2, pp. 221–228.

    Article  PubMed  CAS  Google Scholar 

  85. Cadete-Leite, A., Brandao, F., Andrade, J.P., et al., Alcohol Alcohol., 1997, vol. 32, no. 4, pp. 471–484.

    PubMed  CAS  Google Scholar 

  86. Martin, G., Ahmed, S.H., Blank, T., et al., J. Neurosci., 1999, vol. 19, no. 20, pp. 9081–9089.

    PubMed  CAS  Google Scholar 

  87. Eravci, M., Schulz, O., Grospietsch, T., et al., Br. J. Pharmacol., 2000, vol. 131, no. 3, pp. 423–432.

    Article  PubMed  CAS  Google Scholar 

  88. Tremwel, M.F. and Hunter, B.E., Synapse, 1994, vol. 17, no. 2, pp. 141–148.

    Article  PubMed  CAS  Google Scholar 

  89. Congeddu, E., Saba, L., Porcella, A., et al., Mol. Brain Res., 2003, vol. 110, no. 2, pp. 289–297.

    Article  PubMed  CAS  Google Scholar 

  90. Loh, E.W. and Ball, D., Neurochem. Int., 2000, vol. 37, no. 5–6, pp. 413–423.

    Article  PubMed  CAS  Google Scholar 

  91. Saba, L., Porcella, A., Congeddu, E., et al., Mol. Brain Res., 2001, vol. 87, no. 2, pp. 263–270.

    Article  PubMed  CAS  Google Scholar 

  92. Chen, F., Rezvani, A., Jarrott, B., and Lawrence, A.J., Neurochem. Int., 1998, vol. 32, no. 2, pp. 143–151.

    Article  PubMed  CAS  Google Scholar 

  93. Sanna, A., Congeddu, E., Saba, L., et al., Brain Res., 2004, vol. 998, no. 2, pp. 148–154.

    Article  PubMed  CAS  Google Scholar 

  94. Malatynska, E., Dyr, W., Krzascik, P., and Kostowski, W., Alcohol Alcohol., 2001, vol. 36, no. 4, pp. 309–313.

    PubMed  CAS  Google Scholar 

  95. Burov, Yu.V. and Zhukov, V.N., Teoreticheskie osnovy poiska sredstv dlya lecheniya alkogolisma (Theoretical Basis of a Search for Means for the Treatment of Alcoholism), Itogi nauki i tekhniki, VINITI, ser. Toksikologiya, Val’dman, A.V., Ed., 1988, vol. 13, pp. 57–92.

  96. Ostrovskii, Yu. M. and Sadovnik, M.I., Teoreticheskie osnovy poiska sredstv dlya lecheniya alkogolisma (Theoretical Basis of a Search for Means for the Treatment of Alcoholism), Itogi nauki i tekhniki, VINITI, ser. Toksikologiya, Val’dman, A.V., Ed., 1988, vol. 13, pp. 93–150.

  97. Mitchem, L.D., Kruschel, C.K., Dallman, E., et al., Pharmacol. Biochem. Behav., 1999, vol. 62, no. 1, pp. 97–102.

    Article  PubMed  CAS  Google Scholar 

  98. June, H.L., Grey, C., Warren-Reese, C., et al., Alcohol. Clin. Exp. Res., 1998, vol. 22, no. 9, pp. 2174–2185.

    Article  PubMed  CAS  Google Scholar 

  99. Piepponen, T.P., Kivastik, T., Katajamaki, J., et al., Pharmacol. Biochem. Behav., 1997, vol. 58, no. 1, pp. 275–279.

    Article  PubMed  CAS  Google Scholar 

  100. Matthes, H.W., Maldonado, R., Simonin, F., et al., Nature, 1996, vol. 383, no. 6603, pp. 819–823.

    Article  PubMed  CAS  Google Scholar 

  101. Berrendero, F., Kieffer, B.L., and Maldonado, R., J. Neurosci., 2002, vol. 22, no. 24, pp. 10935–10940.

    PubMed  CAS  Google Scholar 

  102. Bohn, L.M., Gainetdinov, R.R., Sotnikova, T.D., et al., J. Neurosci., 2003, vol. 23, no. 32, pp. 10265–10273.

    PubMed  CAS  Google Scholar 

  103. Suzuki, T., Ikeda, H., Tsuji, M., et al., Life Sci., 1997, vol. 61, no. 11, pp. PL 165–170.

    Article  CAS  Google Scholar 

  104. Nylander, I., Vlaskovska, M., and Terenius, L., Brain Res., 1995, vol. 683, no. 1, pp. 25–35.

    Article  PubMed  CAS  Google Scholar 

  105. Bond, C., LaForge, K.S., Tian, M., et al., Proc. Natl. Acad. Sci. U. S. A., 1998, vol. 95, no. 16, pp. 9608–9613.

    Article  PubMed  CAS  Google Scholar 

  106. Shi, J., Hui, L., Xu, Y., et al., Hum. Mutat., 2002, vol. 19, no. 4, pp. 459–460.

    Article  PubMed  CAS  Google Scholar 

  107. Franke, P., Nothen, M.M., Wang, T., et al., Am. J. Med. Genet., 1999, vol. 88, no. 5, pp. 462–464.

    Article  PubMed  CAS  Google Scholar 

  108. Mayer, P., Rochlitz, H., Rauch, E., et al., Neuroreport., 1997, vol. 8, no. 11, pp. 2547–2550.

    Article  PubMed  CAS  Google Scholar 

  109. Ide, S., Kobayashi, H., Tanaka, K., et al., Ann. N.Y. Acad. Sci., 2004, vol. 1025, pp. 316–324.

    Article  PubMed  CAS  Google Scholar 

  110. Mas-Nieto, M., Pommier, B., Tzavara, E.T., et al., Br. J. Pharmacol., 2001, vol. 132, no. 8, pp. 1809–1816.

    Article  PubMed  CAS  Google Scholar 

  111. Sarnyai, Z., Shaham, Y., and Heinrichs, S.C., Pharmacol. Rev., 2001, vol. 53, no. 2, pp. 209–244.

    PubMed  CAS  Google Scholar 

  112. Basile, A.S., Fedorova, I., Zapata, A., et al., Proc. Natl. Acad. Sci. U. S. A., 2002, vol. 99, no. 17, pp. 11452–11457.

    Article  PubMed  CAS  Google Scholar 

  113. Navarro, M., Carrera, M.R., Fratta, W., et al., J. Neurosci., 2001, vol. 21, no. 14, pp. 5344–5350.

    PubMed  CAS  Google Scholar 

  114. Pontieri, F.E., Monnazzi, P., Scontrini, A., et al., Eur. J.Pharmacol., 2001, vol. 421, no. 3, pp. R1–3.

    Article  PubMed  CAS  Google Scholar 

  115. Vigano, D., Grazia Cascio, M., Rubino, T., et al., Neuropsychopharmacology., 2003, vol. 28, no. 6, pp. 1160–1167.

    PubMed  CAS  Google Scholar 

  116. Castane, A., Valjent, E., Ledent, C., et al., Neuropharmacology, 2002, vol. 43, no. 5, pp. 857–867.

    Article  PubMed  CAS  Google Scholar 

  117. Cossu, G., Ledent, C., Fattore, L., et al., Behav. Brain Res, 2001, vol. 118, no. 1, pp. 61–65.

    Article  PubMed  CAS  Google Scholar 

  118. Martin, M., Ledent, C., Parmentier, M., et al., Eur. J. Neurosci., 2000, vol. 12, no. 11, pp. 4038–4046.

    Article  PubMed  CAS  Google Scholar 

  119. Naassila, M., Pierrefiche, O., Ledent, C., and Daoust, M., Neuropharamcology, 2004, vol. 46, no. 2, pp. 243–253.

    Article  CAS  Google Scholar 

  120. Rice, O.V., Gordon, N., and Gifford, A.N., Brain Res., 2002, vol. 945, no. 1, pp. 135–138.

    Article  PubMed  CAS  Google Scholar 

  121. Reibaud, M., Obinu, M.C., Ledent, C., et al., Eur. J. Pharmacol., 1999, vol. 379, no. 1, pp. R1–2.

    Article  PubMed  CAS  Google Scholar 

  122. Bohme, G.A., Laville, M., Ledent, C., et al., Neuroscience, 2000, vol. 95, no. 1, pp. 5–7.

    Article  PubMed  CAS  Google Scholar 

  123. Kunos, G. and Batkai, S., Neurochem. Res., 2001, vol.26, no. 8–9, pp. 1015–1021.

    Article  PubMed  CAS  Google Scholar 

  124. Comings, D.E., Muhleman, D., Gade, R., et al., Mol. Psychiatry, 1997, vol. 2, no. 2, pp. 161–168.

    Article  PubMed  CAS  Google Scholar 

  125. Heller, d., Schneider, U., Seifert, J., et al., Addict. Biol., 2001, vol. 6, no. 2, pp. 183–187.

    Article  PubMed  CAS  Google Scholar 

  126. Zhang, P.W., Ishiguro, H., Ohtsuki, T., et al., Mol. Psychiatry, 2004, vol. 9, no. 10, pp. 916–931.

    Article  PubMed  CAS  Google Scholar 

  127. Koob, G.F., Neuropsychopharmacol., 2003, vol. 13, no. 6, pp. 442–52.

    Article  CAS  Google Scholar 

  128. Koob, G.F. and Weiss, F., Recent Dev. Alcohol., 1992, vol. 10, pp. 201–233.

    PubMed  CAS  Google Scholar 

  129. Weiss, F., Ciccocioppo, R., Parsons, L.H., et al., Ann. N. Y. Acad. Sci., 2001, vol. 937, pp. 1–26.

    Article  PubMed  CAS  Google Scholar 

  130. Sarnyai, Z. and Kovacs, G.L., Psychoneuroendocrinology 1994, vol. 19, no. 1, pp. 85–117.

    Article  PubMed  CAS  Google Scholar 

  131. Meunier, J.C., Therapie, 2001, vol. 56, no. 3, pp. 227–234 (Article in French).

    PubMed  CAS  Google Scholar 

  132. Murtra, P., Sheasby, A.M., Hunt, S.P., and De Felipo, C., Nature, 2000, vol. 405, no. 6783, pp. 180–183.

    Article  PubMed  CAS  Google Scholar 

  133. De Jong, I.E.M. and De Kloet, E.R., Ann. N. Y. Acad. Sci., 2004, vol. 1018, no. 1, pp. 192–198.

    Article  PubMed  CAS  Google Scholar 

  134. Hamdy, M.M., Mamiya, T., Noda, Y., et al., Behav. Brain Res., 2001, vol. 118, no. 1, pp. 85–93.

    Article  PubMed  CAS  Google Scholar 

  135. Kaewsuk, S., Hutamekalin, P., Ketterman, A.J., et al., Eur. J. Pharmacol., 2001, vol. 411, no. 1–2, pp. 11–16.

    Article  PubMed  CAS  Google Scholar 

  136. Machelska, H., Ziolkowska, B., Mika, J., et al., Neuroreport., 1997, vol. 8, no. 12, pp. 2743–2747.

    Article  PubMed  CAS  Google Scholar 

  137. Przewlocka, B., Lason, W., Przewlocki, R., Neuroscience, 1994, vol. 63, no. 4, pp. 1111–1116.

    Article  PubMed  CAS  Google Scholar 

  138. Kumar, S. and Bhargava, H.N., Gen. Pharmacol., 1997, vol. 29, no. 2, pp. 223–227.

    PubMed  CAS  Google Scholar 

  139. Ikemoto, M., Osugi, T., Wang, X.B., et al., Neuroreport., 1995, vol. 6, no. 2, pp. 262–264.

    Article  PubMed  CAS  Google Scholar 

  140. Osugi, T., Ikemoto, M., Tanaka, H., et al., Mol. Brain Res., 1994, vol. 21, no 3–4. pp. 256–262.

    Article  PubMed  CAS  Google Scholar 

  141. Lou, L., Zhou, T., Wang, P., and Pei, G., Mol. Pharmacol., 1999, vol. 55, no. 3, pp. 557–563.

    PubMed  CAS  Google Scholar 

  142. Garcia, M.M., Gilster, J., and Harlan, R.E., Brain Res., 1996, vol. 734, no. 1–2, pp. 123–134.

    Article  PubMed  CAS  Google Scholar 

  143. Erdtmann-Vourliotis, M., Mayer, P., Riechert, U., and Hollt, V., Mol. Brain Res., 1999, vol. 71, no. 2, pp. 313–324.

    Article  PubMed  CAS  Google Scholar 

  144. Shichinohe, S., Ozawa, H., Saito, T., et al., Alcohol. Clin. Exp. Res., 1998, vol. 22, no. 3, Suppl. pp. 84S–87S.

    Article  PubMed  CAS  Google Scholar 

  145. Escriba, P.V., Sastre, M., and Garcia-Sevilla, J.A., Arch. Gen. Psychiatry, 1994, vol. 51, no. 6, pp. 494–501.

    PubMed  CAS  Google Scholar 

  146. Garcia-Sevilla, J.A., Ventayol, P., Busquets, X., et al., Neurosci. Lett., 1997, vol. 226, no. 1, pp. 29–32.

    Article  PubMed  CAS  Google Scholar 

  147. Hashimoto, E., Frolich, L., Ozawa, H., et al., Alcohol. Clin. Exp. Res., 1996, vol. 20, no. 9, Suppl. pp. 301A–304A.

    Article  PubMed  CAS  Google Scholar 

  148. Busquets, X., Escriba, P.V., Sastre, M., and Garcia-Sevilla, J.A., J. Neurochem., 1995, vol. 64, no. 1, pp. 247–252.

    Article  PubMed  CAS  Google Scholar 

  149. Ferrer-Alcon, M., La Harpe, R., and Garcia-Sevilla, J.A., Mol. Brain Res., 2004, vol. 121, no. 1–2, pp. 114–122.

    Article  PubMed  CAS  Google Scholar 

  150. Ozaita, A., Escriba, P.V., Ventayol, P., et al., J. Neurochem., 1998, vol. 70, no. 3, pp. 1249–1257.

    Article  PubMed  CAS  Google Scholar 

  151. Bishop, G., Cullinan, W., Curran, E., and Gutstein, H., Neurobiol. Dis., 2002, vol. 10, no. 3, p. 334.

    Article  PubMed  CAS  Google Scholar 

  152. Erdtmann-Vourliotis, M., Mayer, P., Linke, R., et al., Mol. Brain Res., 1999, vol. 72, no. 1, pp. 1–16.

    Article  PubMed  CAS  Google Scholar 

  153. Erdtmann-Vourliotis, M., Mayer, P., Riechert, U., et al., Mol. Brain Res., 1998, vol. 61, no. 1–2, pp. 51–61.

    Article  PubMed  CAS  Google Scholar 

  154. Pontieri, F.E., Calo, L., Di Grezia, R., et al., Eur. J. Pharmacol., 1997, vol. 335, no. 2–3, pp. 133–137.

    Article  PubMed  CAS  Google Scholar 

  155. Frankel, P.S., Harlan, R.E., and Garcia, M.M., Brain Res., 1999, vol. 835, no. 2, pp. 204–212.

    Article  PubMed  CAS  Google Scholar 

  156. Tolliver, B.K., Sganga, M.W., and Sharp, F.R., Eur. J. Neurosci., 2000, vol. 12, no. 9, pp. 3399–3406.

    Article  PubMed  CAS  Google Scholar 

  157. Lu, L., Zeng, S., Liu, D., and Ceng, X., Neurosci. Lett., 2000, vol. 291, no. 3, pp. 191–195.

    Article  PubMed  CAS  Google Scholar 

  158. Fan, G.H., Wang, L.Z., Qiu, H.C., et al., Mol. Pharmacol., 1999, vol. 56, no. 1, pp. 39–45.

    PubMed  CAS  Google Scholar 

  159. Krupitskii, E.M., Burakov, A.M., Priputina, L.S., et al., Zh. Nevrologii i psikhiatrii im Korsakova, S.S., 2004, vol. 104, no. 7, pp. 50–53.

    CAS  Google Scholar 

  160. Antidepressanty b terapii patologicheskogo vlecheniya k psikhotropnym veshchestvam (Antidepressants in Theraphy of Pathological Attraction to Psychotropic Substances), Ivanets, N.N., Ed., Moscow: Politek-F, 2000.

    Google Scholar 

  161. Shabanov, P.D. and Shtakel’berg, O.Yu., Narkomanii: patopsikhologiya, klinika, reabilitatsyya (Narcotism: Pathological Psychology, Clinics, Reabilitation), Grinenko, A.Ya., Ed., SPb: Lan’, 2000.

    Google Scholar 

  162. Ivanets, N.N. and Vinnikova, M.A., Heroinovaya narkomaniya (postabstinentnoe sostoyanie: klinika i lechenie (Heroin Narcotism (Posyabstinence: Clinics and Treatment), Moscow: Medpractika, 2000.

    Google Scholar 

  163. Voronin, K.E., Lektsii po narkologii (Lectures on Narcology), Ivanets, N.N., Ed., Moscow: Nolidzh, 2000, pp. 250–270.

    Google Scholar 

  164. Wilde, M.I. and Wagstaff, A.J., Drugs, 1997, vol. 53, no. 6, pp. 1038–1053.

    Article  PubMed  CAS  Google Scholar 

  165. Krutitskii, E.M., Zvartau, E.E., Masalov, D.V., et al., Psikhiatriya konsul’tirovaniya i vzaimodeistviya (Psychiatry of Consultation and Interaction), Vanchakova, N.P., Ed., 2003, pp. 54–55.

  166. Vetulani, J., Pol. J. Pharmacol., 2001, vol. 53, no. 5, pp. 415–434.

    PubMed  CAS  Google Scholar 

  167. Khersh, D., Peili, D. Renner, D.A. Jn., Narcologiya (Narcology), Fridman, L.S., Fleming, N.S., Roberts, D.Kh., and Khaiman, S.E., Moscow-SPb: Binom, Nevskii dialect, 1998, pp. 187–199.

    Google Scholar 

  168. Sivolap, Yu.P., and Savchenkov, V.A., Zh. Nevrologii i psikhiatrii im. Korsakova, S.S., 2000, vol. 100, no. 5, pp. 66–70.

    Google Scholar 

  169. O’Malley, S.S. and Froehlich, J.C., Recent Dev. Alcohol., 2003, vol. 16, pp. 217–245.

    Article  PubMed  Google Scholar 

  170. Olsen, L., Christophersen, A.S., Frogopsahl. G., et al., Br. J. Clin. Pharmacol., 2004, vol. 58, no. 2, pp. 219–222.

    Article  PubMed  CAS  Google Scholar 

  171. Collins, S.L. and Kantak, K.M., Psychopharmacology (Berlin), 2002, vol. 159, no. 4, pp. 361–369.

    Article  CAS  Google Scholar 

  172. Lallemand, F. and De Witte, P., Pharmacol. Biochem. Behav., 1997, vol. 58, no. 3, pp. 753–761.

    Article  PubMed  CAS  Google Scholar 

  173. Self, D.W., Genova, L.M., Hope, B.T., et al., J. Neurosci., 1998, vol. 18, no. 5, pp. 1848–1859.

    PubMed  CAS  Google Scholar 

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  1. Bekhterev Regional Center of Therapy and Diagnostic, ul. Korabelnaya 6, St. Petersburg, 198096, Russia

    A. I. Golovko & S. I. Golovko

  2. State University of New York, Upstate Medical University, Syracuse, USA

    L. V. Leontieva

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Original Russian Text © A.I. Golovko, S.I. Golovko, L.V. Leontieva, 2007, published in Neirokhimiya, 2006, Vol. 23, No. 1, pp. 5–18.

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Golovko, A.I., Golovko, S.I. & Leontieva, L.V. The neurochemistry of the psychological dependence syndrome in addictive diseases of chemical etiology. Neurochem. J. 1, 1–13 (2007). https://doi.org/10.1134/S1819712407010011

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