Polymer Science Series C

, Volume 52, Issue 1, pp 122–133 | Cite as

Conformational changes of a DNA molecule induced by metal complexes formed in solution

  • N. A. Kasyanenko
  • D. A. Mukhin
  • I. Yu. Perevyazko


Changes in the tertiary structure of a high-molecular-mass DNA in solution that result from the addition of trivalent lanthanum ions, including intramolecular structuring of the macromolecule, are studied by atomic-force microscopy. The effect of bivalent magnesium and manganese ions on the structure of DNA in an aqueous-alcohol solution is analyzed. The data are compared with the results of viscometry, dynamic light scattering, flow birefringence, circular dichroism, and UV spectrophotometry.


Lanthanum Polymer Science Series Alcohol Concentration Specific Viscosity Flow Birefringence 
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  1. 1.
    N. C. Seeman, Biochemistry 42, 7259 (2003).CrossRefGoogle Scholar
  2. 2.
    R. P. Goodman, I. A. T. Schaap, C. F. Tardin, et al., Science (Washington, D. C.) 310, 166 (2005).CrossRefGoogle Scholar
  3. 3.
    E. Ben-Jacob, Z. Hermon, and S. Caspi, Phys. Rev. Lett., A 263, 199 (1999).Google Scholar
  4. 4.
    A. Ongaro, F. Griffin, L. Nagle, et al., Adv. Mater. (Weinheim, Fed. Repub. Ger.) 16, 1799 (2004).CrossRefGoogle Scholar
  5. 5.
    C. P. Mountford, A. H. Buck, C. G. Campbell, et al., J. Phys. Chem. B 112, 2439 (2008).CrossRefGoogle Scholar
  6. 6.
    K. Kanatani, Y. Ochi, A. Okamoto, and L. Saito, Nucleic Acids Res., No. 3, 161 (2003).Google Scholar
  7. 7.
    S-H. Park, R. Barish, H. Li, et al., Nano Lett. 5, 693 (2005).CrossRefGoogle Scholar
  8. 8.
    J. F. Hainfeld, F. R. Furuya, R. D. Powell, and W. Liu, Microsc. Microanal. 7, 1034 (2001).Google Scholar
  9. 9.
    L. Cai, H. Tabata, and T. Kawai, Appl. Phys. Lett. 77, 3105 (2000).CrossRefGoogle Scholar
  10. 10.
    I. L. Volkov, N. V. Bazlov, A. S. Bondarenko, et al., Zh. Strukt. Khim. 50, 994 (2009).Google Scholar
  11. 11.
    E. V. Frisman and N. A. Kas’yanenko, Mol. Biol. (Moscow) 24, 301 (1990).Google Scholar
  12. 12.
    N. A. Kas’yanenko, Zh. Strukt. Khim. 47, 163 (2006).Google Scholar
  13. 13.
    N. A. Kas’yanenko, G. N. Sel’man-Khusein Sosa, V. N. Uverskii, and E. V. Frisman, Mol. Biol. (Moscow) 21, 140 (1987).Google Scholar
  14. 14.
    N. A. Kas’yanenko, H. E. D’yakonova, and E. V. Frisman, Mol. Biol. (Moscow) 23, 835 (1989).Google Scholar
  15. 15.
    A. H. Veselkov, V. A. Moroshkin, I. D. Polyakova, et al., Mol. Biol. (Moscow) 10, 1050 (1976).Google Scholar
  16. 16.
    N. Kasyanenko, N. Arikainen, and E. Frisman, Biophys. Chem. 70, 93 (1998).CrossRefGoogle Scholar
  17. 17.
    N. A. Kasyanenko, A. V. Zanina, O. V. Nazarova, and E. F. Panarin, Langmuir 15, 7912 (1999).CrossRefGoogle Scholar
  18. 18.
    N. Kasyanenko and D. Afanasieva, in NATO Science for Peace and Security, Ser. B: Phys. Biophys. Nanomaterials for Application in Medicine and Biology, Ed. by M. Giersig and G. Khomutov (Springer, The Netherlands, 2008), p. 29.Google Scholar
  19. 19.
    L. S. Lerman, Proc. Natl. Acad. Sci. U. S. A. 68, 1886 (1971).CrossRefGoogle Scholar
  20. 20.
    L. C. Gosule and J. A. Schellman, Nature (London) 259, 333 (1976).CrossRefGoogle Scholar
  21. 21.
    J. Widom and R. L. Baldwin, J. Mol. Biol. 144, 431 (1980).CrossRefGoogle Scholar
  22. 22.
    R. W. Wilson and V. A. Bloomfield, Biochemistry 18, 2192 (1979).CrossRefGoogle Scholar
  23. 23.
    V. A. Bloomfield, Biopolymers 31, 1471 (1991).CrossRefGoogle Scholar
  24. 24.
    N. A. Kasyanenko, D. A. Afanasieva, B. A. Dribinsky, et al., Struct. Chem. 18, 519 (2007).CrossRefGoogle Scholar
  25. 25.
    S. Y. Park, D. Harries, and W. M. Gelbart, Biophys. J. 75, 714 (1998).CrossRefGoogle Scholar
  26. 26.
    N. A. Kas’yanenko and L. V. Plotnikova, Vestn. S.-Peterb. Gos. Univ., Ser. 4: Fiz., Khim. (2001).Google Scholar
  27. 27.
    N. A. Kas’yanenko, L. V. Plotnikova, A. V. Zanina, et al., Biofizika 47, 433 (2002).Google Scholar
  28. 28.
    A. V. Slita, N. A. Kasyanenko, O. V. Nazarova, et al., J. Biotechnol. 127, 679 (2007).CrossRefGoogle Scholar
  29. 29.
    N. A. Kas’yanenko, N. B. Zakharova, D. A. Mukhin, et al., Biofizika 53, 31 (2008).Google Scholar
  30. 30.
    N. A. Kasyanenko, S. A. Prokhorova, E. E. F. Haya, et al., Colloids Surf., A 148, 121 (1999).CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • N. A. Kasyanenko
    • 1
  • D. A. Mukhin
    • 1
  • I. Yu. Perevyazko
    • 1
  1. 1.Faculty of PhysicsSt. Petersburg State UniversityPetrodvorets, St. PetersburgRussia

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