Doklady Biochemistry and Biophysics

, Volume 485, Issue 1, pp 141–144 | Cite as

Neuroprotective Action of Amidic Neurolipins in Models of Neurotoxicity on the Culture of Human Neural-Like Cells SH-SY5Y

  • M. G. AkimovEmail author
  • A. M. Ashba
  • E. V. Fomina-Ageeva
  • N. M. Gretskaya
  • N. F. Myasoedov
  • V. V. Bezuglov


It was established that in neurodegeneration models in the human neuron-like cell line SH-SY5Y, amide derivatives of arachidonic and docosahexaenoic acids were inactive in experiments with MPP+ and CoCl2 but protected from H2O2. The protective activity of neurolipins decreased in the series DHA-DA > AA-SER ≥ AA-GLY > AA-GABA ≥ AA-EA and was manifested starting from a concentration of 0.5 nM.



This study was supported by the Russian Foundation for Basic Research (project no. 17-00-00105 and 17-00-00109).


The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • M. G. Akimov
    • 1
    Email author
  • A. M. Ashba
    • 1
  • E. V. Fomina-Ageeva
    • 1
  • N. M. Gretskaya
    • 1
  • N. F. Myasoedov
    • 2
  • V. V. Bezuglov
    • 1
  1. 1.Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscowRussia
  2. 2.Institute of Molecular Genetics, Russian Academy of SciencesMoscowRussia

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