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Doklady Biochemistry and Biophysics

, Volume 485, Issue 1, pp 126–128 | Cite as

The Generation of the Human mAb RabD4 Specific to the Rabies Virus Glycoprotein and Characterization Thereof

  • E. N. IlinaEmail author
  • E. V. Solopova
  • T. K. Aliev
  • M. V. Larina
  • D. S. Balabashin
  • N. E. Varlamov
  • D. A. Dolgikh
  • P. G. Sveshnikov
  • M. P. Kirpichnikov
BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

We generated a novel human neutralizing human mAb RabD4 against rabies virus glycoprotein using in vitro stimulation of human peripheral B cells produced by immunized donor. The human mAb RabD4 showed a high antigen-binding activity and virus-neutralizing activity in the FAVN test with the CVS-11 rabies virus.

Notes

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • E. N. Ilina
    • 1
    Email author
  • E. V. Solopova
    • 2
  • T. K. Aliev
    • 1
  • M. V. Larina
    • 3
  • D. S. Balabashin
    • 3
  • N. E. Varlamov
    • 2
  • D. A. Dolgikh
    • 1
    • 3
  • P. G. Sveshnikov
    • 2
  • M. P. Kirpichnikov
    • 1
    • 3
  1. 1.Moscow State UniversityMoscowRussia
  2. 2.All-Russia Research Center of Molecular Diagnostics and TherapyMoscowRussia
  3. 3.Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscowRussia

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