Skip to main content
SpringerLink
Log in

Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
  • Published:
Doklady Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) loop 4, GSB-106, which, similarly to BDNF, activated TrkB, PI3K/AKT, and MAPK/ERK. When administered systemically, it exhibited neuroprotective, antidepressant, and antidiabetic activities and stimulated neurogenesis and synaptogenesis. In this study, we established that GSB-106 also exhibits the analgesic activity, typical for BDNF, which was revealed in rats in hot plate and tail flick tests 0.5–48 h after intraperitoneal injection at doses of 0.1 and 1 mg/kg.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

REFERENCES

  1. Kaplan, D.R. and Miller, F.D., Curr. Opin. Neurobiol., 2000, vol. 10, pp. 381–391.

    Article  CAS  PubMed  Google Scholar 

  2. Autry, A.E. and Monteggia, L.M., Pharmacol. Rev., 2012, vol. 64, no. 2, pp. 238–258.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Thoenen, H. and Sendtner, M., Nat. Neurosci., 2002, vol. 5, pp. 1046–1050.

    Article  CAS  PubMed  Google Scholar 

  4. Robinson, R.C., Radziejewski, C., Stuart, D.I., and Jones, E.Y., Biochemistry, 1995, vol. 34, no. 13, pp. 4139– 4146.

    Article  CAS  PubMed  Google Scholar 

  5. Gudasheva, T.A., Tarasyuk, A.V., Pomogaibo, S.V., Logvinov, I.O., Povarnina, P.Yu., Antipova, T.A., and Seredenin, S.B., Russ. J. Bioorg. Chem., 2012, vol. 38, no. 3, pp. 243–252.

    Article  CAS  Google Scholar 

  6. Gudasheva, T.A., Tarasyuk, A.V., Sazonova, N.M., Povarnina, P.Yu., Antipova, T.A., and Seredenin, S.B., Dokl. Akad. Nauk, 2017, vol. 476, pp. 108–112.

    Google Scholar 

  7. Gudasheva, T.A., Povarnina, P.Yu., Logvinov, I.O., Antipova, T.A., and Seredenin, S.B., Drug Des. Devel. Ther., 2016, no. 10, pp. 3545–3553.

  8. Seredenin, S.B., Voronina, T.A., Gudasheva, T.A., Garibova, T.L., Molodavkin, G.M., Litvinova, S.A., Elizarova, O.A., and Poseva, V.I., Acta Naturae, 2013, vol. 5, no. 4, pp. 116–120.

    Article  Google Scholar 

  9. Tallerova, A.V., Povarnina, P.Yu., Blynskaya, E.V., Bueva, V.V., Gudasheva, T.A., and Seredenin, S.B., Khim.-Farm. Zh., 2018, vol. 52, no. 5, pp. 15–17.

    Google Scholar 

  10. Gudasheva, T.A., Povarnina, P.Yu., and Seredenin, S.B., Bull. Exp. Biol. Med., 2016, vol. 162, no. 9, pp. 448–451.

    Google Scholar 

  11. Gudasheva, P.Yu., Povarnina, T.A., and Antipova, S.B., Seredenin, Dokl. Biochem. Biophys., 2018, vol. 481, pp. 225–227.

    Article  CAS  PubMed  Google Scholar 

  12. Ostrovskaya, R.U., Yagubova, S.S., Gudasheva, T.A., and Seredenin, S.B., Bull. Exp. Biol. Med., 2017, vol. 164, no. 12, pp. 701–705.

    Google Scholar 

  13. Siuciak, J.A., Altar, C.A., Wiegand, S.J., and Lindsay, R.M., Brain Res., 1994, vol. 633, nos. 1–2, pp. 326–330.

    Article  CAS  PubMed  Google Scholar 

  14. Siuciak, J.A., Wong, V., Pearsall, D., Wiegand, S.J., and Lindsay, R.M., Eur. J. Neurosci., 1995, vol. 7, no. 4, pp. 663–670.

    Article  CAS  PubMed  Google Scholar 

  15. Le Bars, D., Gozariu, M., and Cadden, S.W., Pharmacol. Rev., 2001, vol. 53, no. 4, pp. 597–652.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, 125315, Moscow, Russia

    T. A. Gudasheva, M. A. Konstantinopolsky, A. V. Tarasiuk, L. G. Kolik &  S. B. Seredenin

Authors
  1. T. A. Gudasheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. A. Konstantinopolsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. V. Tarasiuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. G. Kolik
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. B. Seredenin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. A. Gudasheva.

Additional information

Translated by M. Batrukova

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gudasheva, T.A., Konstantinopolsky, M.A., Tarasiuk, A.V. et al. Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity. Dokl Biochem Biophys 485, 123–125 (2019). https://doi.org/10.1134/S1607672919020121

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1607672919020121

Search

Navigation