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Doklady Biochemistry and Biophysics

, Volume 485, Issue 1, pp 115–118 | Cite as

Loading Rate of Exogenous and Autoantigenic Determinants on Major Histocompatibility Complex Class II Mediates Resistance to Multiple Sclerosis

  • A. E. MamedovEmail author
  • M. Yu. Zakharova
  • O. O. Favorova
  • O. G. Kulakova
  • A. N. Boyko
  • V. D. KnorreEmail author
  • N. A. Vorobieva
  • E. N. Khurs
  • I. S. Kiselev
  • N. M. Baulina
  • A. G. Gabibov
  • A. A. Belogurov
BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

Genetic analysis of thousands of patients with multiple sclerosis (MS) and healthy Russian donors showed that the carriage of groups of HLA-DRB1*15 and HLA-DRB1*03 alleles is associated with the risk of MS, whereas the carriage of groups of HLA-DRB1*01 and HLA-DRB1*11 alleles is protective. Recombinant HLA-DRB1*01:01 with a high affinity can recognize the fragments of myelin basic protein (MBP), one of the autoantigens in MS. However, the comparison of the kinetic parameters of the load of MBP and viral HA peptides on HLA-DRB1*01:01, which is catalyzed by HLA-DM, showed a significantly lower rate of exchange of CLIP for MBP peptides. We assume that the observed protective properties of the group of HLA-DRB1*01 alleles may be directly associated with the ability of HLA-DRB1*01:01 to kinetically distinguish peptides of exogenous and endogenous nature.

Notes

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • A. E. Mamedov
    • 1
    Email author
  • M. Yu. Zakharova
    • 1
    • 2
  • O. O. Favorova
    • 2
  • O. G. Kulakova
    • 2
  • A. N. Boyko
    • 2
  • V. D. Knorre
    • 1
    Email author
  • N. A. Vorobieva
    • 3
  • E. N. Khurs
    • 4
  • I. S. Kiselev
    • 2
  • N. M. Baulina
    • 2
  • A. G. Gabibov
    • 1
    • 5
  • A. A. Belogurov
    • 1
    • 5
  1. 1.Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesMoscowRussia
  2. 2.Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian FederationMoscowRussia
  3. 3.Institute of Gene Biology, Russian Academy of SciencesMoscowRussia
  4. 4.Engelhardt Institute of Molecular Biology, Russian Academy of SciencesMoscowRussia
  5. 5.Biological Faculty, Moscow State UniversityMoscowRussia

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