Doklady Biochemistry and Biophysics

, Volume 485, Issue 1, pp 95–100 | Cite as

Architecture of Promoters of House-Keeping Genes in Polytene Chromosome Interbands of Drosophila melanogaster

  • T. Yu. ZykovaEmail author
  • V. G. Levitsky
  • I. F. Zhimulev


This is the first study to investigate the molecular-genetic organization of polytene chromosome interbands located on both molecular and cytological maps of Drosophila genome. The majority of the studied interbands contained one gene with a single transcription initiation site; the remaining interbands contained one gene with several alternative promoters, two or more unidirectional genes, and “head-to-head” arranged genes. In addition, intricately arranged interbands containing three or more genes in both unidirectional and bidirectional orientation were found. Insulator proteins, ORC, P-insertions, DNase I hypersensitive sites, and other open chromatin structures were situated in the promoter region of the genes located in the interbands. This area is critical for the formation of the interband, an open chromatin region in which gene transcription and replication are combined.



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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • T. Yu. Zykova
    • 1
    Email author
  • V. G. Levitsky
    • 2
    • 3
  • I. F. Zhimulev
    • 1
    • 3
  1. 1.Institute of Molecular and Cellular Biology, Siberian Branch, Russian Academy of SciencesNovosibirskRussia
  2. 2.Institute of Cytology and Genetics, Siberian Branch, Russian Academy of SciencesNovosibirskRussia
  3. 3.Novosibirsk State UniversityNovosibirskRussia

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