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Effect of New Derivatives of 2-Aminothiophene-3-Carboxylic Acid on Calcium-Activated Chloride Currents in Rat Neurons

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

Using the patch-clamp method in the whole-cell configuration, we showed that the new derivatives of 2-aminothiophene-3-carboxylic acid, which were synthesized by us earlier, can both block (compound 1) and potentiate (compound 2) calcium-activated chloride currents in single rat cerebellar Purkinje cells.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow oblast, 142432, Russia

    V. V. Grigoriev, V. L. Zamoyski, A. V. Aksinenko & V. B. Sokolov

Authors
  1. V. V. Grigoriev
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  2. V. L. Zamoyski
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  3. A. V. Aksinenko
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  4. V. B. Sokolov
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  5. S. O. Bachurin
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Corresponding author

Correspondence to V. L. Zamoyski.

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Original Russian Text © V.V. Grigoriev, V.L. Zamoyski, A.V. Aksinenko, V.B. Sokolov, S.O. Bachurin, 2018, published in Doklady Akademii Nauk, 2018, Vol. 483, No. 1.

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Grigoriev, V.V., Zamoyski, V.L., Aksinenko, A.V. et al. Effect of New Derivatives of 2-Aminothiophene-3-Carboxylic Acid on Calcium-Activated Chloride Currents in Rat Neurons. Dokl Biochem Biophys 483, 293–296 (2018). https://doi.org/10.1134/S1607672918060042

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  • DOI: https://doi.org/10.1134/S1607672918060042

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