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Epoxygenase Inhibitors Attenuate the Stimulatory Effect of Glutoxim on Na+ Transport in Frog Skin

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

Using voltage-clamp technique, the involvement of epoxygenases in immunomodulatory drug glutoxim regulation of Na+ transport in frog skin was investigated. We have shown for the first time that preincubation of the frog skin with epoxygenase inhibitors econazole or proadifen almost completely inhibits the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of the enzymes and/or products of epoxygenase oxidation pathway of arachidonic acid metabolism in glutoxim effect on Na+ transport in frog skin epithelium.

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Authors and Affiliations

  1. St. Petersburg State University, St. Petersburg, 199034, Russia

    Z. I. Krutetskaya, A. V. Melnitskaya, V. G. Antonov & A. D. Nozdrachev

Authors
  1. Z. I. Krutetskaya
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  2. A. V. Melnitskaya
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  3. V. G. Antonov
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  4. A. D. Nozdrachev
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Corresponding author

Correspondence to Z. I. Krutetskaya.

Additional information

Original Russian Text © Z.I. Krutetskaya, A.V. Melnitskaya, V.G. Antonov, A.D. Nozdrachev, 2018, published in Doklady Akademii Nauk, 2018, Vol. 480, No. 4, pp. 499–502.

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Krutetskaya, Z.I., Melnitskaya, A.V., Antonov, V.G. et al. Epoxygenase Inhibitors Attenuate the Stimulatory Effect of Glutoxim on Na+ Transport in Frog Skin. Dokl Biochem Biophys 480, 152–154 (2018). https://doi.org/10.1134/S1607672918030079

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  • DOI: https://doi.org/10.1134/S1607672918030079

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