Abstract
We studied the possibility of optimizing modular nanotransporters (MNTs) for the intracellular delivery of antibody fragments into the nuclei of cells of a specified type. Basic MNT with a reduced size retaining the desired functions was obtained, and the principal possibility of obtaining an MNT carrying an antibody fragment by microbiological synthesis was shown.
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Original Russian Text © A.V. Ulasov, Y.V. Khramtsov, T.N. Lupanova, A.D. Tsvetkova, A.A. Rosenkranz, T.A. Slastnikova, G.P. Georgiev, A.S. Sobolev, 2018, published in Doklady Akademii Nauk, 2018, Vol. 479, No. 1, pp. 92–95.
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Ulasov, A.V., Khramtsov, Y.V., Lupanova, T.N. et al. MNT Optimization for Intracellular Delivery of Antibody Fragments. Dokl Biochem Biophys 479, 62–65 (2018). https://doi.org/10.1134/S1607672918020023
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DOI: https://doi.org/10.1134/S1607672918020023