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VEGF-R1 as a Potential Molecular Target for Anticancer Therapy

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

The possibility of using VEGF-R1 receptor for targeted therapy in oncology was investigated. Using the approach to measuring the protein content in intact nuclei of cells, which was developed by us, we showed the presence of this receptor in the nuclei of tumor, but not normal cells. A direct correlation between the level of VEGF-R1 expression in the nucleus and the degree of malignancy of tumor cells, indicating the prognostic value of this parameter, was found. The mechanisms of the functioning of this receptor and the pathways of inhibiting its activity are discussed, and the validity of the selection of VEGF-R1 as a molecular target for anticancer therapy is conformed.

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References

  1. Fan, F., Wey, J.S., McCarty, M.F., et al., Oncogen, 2005, vol. 24, pp. 2647–2653.

    Article  CAS  Google Scholar 

  2. Wey, J.S., Fan, F., Gray, M.J., et al., Cancer, 2005, vol. 104, pp. 427–438.

    Article  CAS  PubMed  Google Scholar 

  3. Lee, T.-H., Seng, S., Sekine, M., et al., PLoS Medicine, 2007, vol. 4, no. 6, pp. 1001–1016.

    Article  Google Scholar 

  4. Bhattacharya, R., Ye, X.C., Wang, R., et al., Cancer Res., 2016, vol. 76, no. 10, pp. 3014–3024. doi: 10.1158/0008-5472.CAN-15-1605

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Tyrsina, E.G., Nikulitskii, S.I., Inshakov, A.N., and Ryabaya, O.O., Onkoginekologiya, 2016, no. 2, pp. 13–21.

    Google Scholar 

  6. Nikulitskii, S.I., Tyrsina, E.G., Inshakov, A.N., and Borovkova, N.B., Ross. Bioterapevt. Zh., 2016, no. 2, pp. 75–80.

    Google Scholar 

  7. Szabo, E., Schneider, H., Seystahl, K., et al., Neuro Oncol., 2016, no. 9, pp. 1242–1252. doi: 10.1093/neuonc/now043

    Article  Google Scholar 

  8. Vincent, L., Jin, D.K., Karajannis, M.A., et al., Cancer Res., 2005, vol. 65, pp. 3185–3192.

    Article  CAS  PubMed  Google Scholar 

  9. Owen, L.A., Uehara, H., Cahoon, J., et al., PLoS ONE, 2013, vol. 7, no. 3, p. e33576.

    Article  Google Scholar 

  10. Broers, J.L.V. and Ramaekers, F.C.S., Adv. Exp. Med. Biol., 2014, vol. 773, pp. 27–48. doi 10.1007/978-1-4899-8032-8_2.2. PMID:24563342

    Article  CAS  PubMed  Google Scholar 

  11. Chen, M.-K. and Hung, M.-C., Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases, FEBS J., 2015, vol. 282, no. 19, pp. 3693–3721. doi 10.1111/febs.13342

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, 115478, Russia

    E. G. Tyrsina, S. I. Nikulitskiy, A. N. Inshakov & O. O. Ryabaya

Authors
  1. E. G. Tyrsina
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  2. S. I. Nikulitskiy
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  3. A. N. Inshakov
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  4. O. O. Ryabaya
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Corresponding author

Correspondence to E. G. Tyrsina.

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Original Russian Text © E.G. Tyrsina, S.I. Nikulitskiy, A.N. Inshakov, O.O. Ryabaya, 2018, published in Doklady Akademii Nauk, 2018, Vol. 478, No. 2, pp. 236–239.

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Tyrsina, E.G., Nikulitskiy, S.I., Inshakov, A.N. et al. VEGF-R1 as a Potential Molecular Target for Anticancer Therapy. Dokl Biochem Biophys 478, 18–20 (2018). https://doi.org/10.1134/S1607672918010052

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  • DOI: https://doi.org/10.1134/S1607672918010052

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