Advertisement

Doklady Biochemistry and Biophysics

, Volume 470, Issue 1, pp 313–315 | Cite as

Gene expression of proteins of the vesicle cycle in the striatum and motor cortex under functional failure of nigrostriatal system

  • E. R. Mingazov
  • M. V. Ugrumov
Biochemistry, Biophysics, and Molecular Biology
  • 43 Downloads

Abstract

Degeneration of dopaminergic neurons in the substantia nigra and the decrease in the dopamine level in the striatum lead to dysfunctions of motor behavior. This is accompanied by dysregulation of neuro-transmission in glutamatergic neurons of the motor cortex and GABA-ergic neurons of the striatum. It is shown that dysregulation of the gene expression of vesicle cycle proteins in neurons of the motor cortex occurs at an early (presymptomatic) stage of degeneration of the nigrostriatal system, and in more severe degeneration (symptomatic stage) the level of gene expression of vesicle cycle proteins in the striatum decreases.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Parent, A. and Hazrati, L., Brain Res. Brain Res. Rev., 1995, vol. 20, pp. 191–127.Google Scholar
  2. 2.
    Obeso, J.F., Rodriguez-Oroz, M. Cruz., and Benitez-Temino, B., Mov. Disord., 2008, vol. 23, pp. 548–559.CrossRefGoogle Scholar
  3. 3.
    Pisani, A., Mov. Disord., 2005, vol. 4, pp. 395–402.CrossRefGoogle Scholar
  4. 4.
    Ehringer, H. and Hornykiewicz, O., Klin. Wochenschr., 1960, vol. 38, pp. 1236–1239.CrossRefPubMedGoogle Scholar
  5. 5.
    Hosp, J.A. and Luft, A.R., Front Neurol., 2013, vol. 4, pp. 1–7.CrossRefGoogle Scholar
  6. 6.
    Sudhof, T.C., Neuron, 2012, vol. 75, pp. 11–25.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Ng, E.L. and Tang, B.L., Brain Res. Rev., 2008, vol. 58, pp. 236–246.CrossRefPubMedGoogle Scholar
  8. 8.
    Agid, Y., Lancet, 1991, vol. 337, pp. 1321–1324.CrossRefPubMedGoogle Scholar
  9. 9.
    Simunovic, F., Yi, M., and Wang, Y., Brain, 2009, vol. 132, pp. 1795–1809.CrossRefPubMedGoogle Scholar
  10. 10.
    Miller, R.M., Callahan, L.M., and Casaceli, C., J. Neurosci., 2004, vols. 7445–7454, no. 34, p. 24.Google Scholar
  11. 11.
    Ugrumov, M.V., Khaindrava, V.G., and Kozina, E.A., Neuroscience, 2011, vol. 181, pp. 175–188.CrossRefPubMedGoogle Scholar
  12. 12.
    Kozina, E.A., Khakimova, G.R., and Khaindrava, V.G., J. Neurol. Sci., 2014, vol. 340, pp. 198–207.CrossRefPubMedGoogle Scholar
  13. 13.
    Calabresi, P., Picconi, B., Tozzi, A., and Filippo, M.D., Trends Neurosci., 2007, vol. 5, pp. 211–219.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Koltzov Institute of Developmental BiologyRussian Academy of SciencesMoscowRussia

Personalised recommendations