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Gene expression of proteins of the vesicle cycle in the striatum and motor cortex under functional failure of nigrostriatal system

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

Degeneration of dopaminergic neurons in the substantia nigra and the decrease in the dopamine level in the striatum lead to dysfunctions of motor behavior. This is accompanied by dysregulation of neuro-transmission in glutamatergic neurons of the motor cortex and GABA-ergic neurons of the striatum. It is shown that dysregulation of the gene expression of vesicle cycle proteins in neurons of the motor cortex occurs at an early (presymptomatic) stage of degeneration of the nigrostriatal system, and in more severe degeneration (symptomatic stage) the level of gene expression of vesicle cycle proteins in the striatum decreases.

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References

  1. Parent, A. and Hazrati, L., Brain Res. Brain Res. Rev., 1995, vol. 20, pp. 191–127.

    Google Scholar 

  2. Obeso, J.F., Rodriguez-Oroz, M. Cruz., and Benitez-Temino, B., Mov. Disord., 2008, vol. 23, pp. 548–559.

    Article  Google Scholar 

  3. Pisani, A., Mov. Disord., 2005, vol. 4, pp. 395–402.

    Article  Google Scholar 

  4. Ehringer, H. and Hornykiewicz, O., Klin. Wochenschr., 1960, vol. 38, pp. 1236–1239.

    Article  CAS  PubMed  Google Scholar 

  5. Hosp, J.A. and Luft, A.R., Front Neurol., 2013, vol. 4, pp. 1–7.

    Article  Google Scholar 

  6. Sudhof, T.C., Neuron, 2012, vol. 75, pp. 11–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ng, E.L. and Tang, B.L., Brain Res. Rev., 2008, vol. 58, pp. 236–246.

    Article  CAS  PubMed  Google Scholar 

  8. Agid, Y., Lancet, 1991, vol. 337, pp. 1321–1324.

    Article  CAS  PubMed  Google Scholar 

  9. Simunovic, F., Yi, M., and Wang, Y., Brain, 2009, vol. 132, pp. 1795–1809.

    Article  PubMed  Google Scholar 

  10. Miller, R.M., Callahan, L.M., and Casaceli, C., J. Neurosci., 2004, vols. 7445–7454, no. 34, p. 24.

    Google Scholar 

  11. Ugrumov, M.V., Khaindrava, V.G., and Kozina, E.A., Neuroscience, 2011, vol. 181, pp. 175–188.

    Article  CAS  PubMed  Google Scholar 

  12. Kozina, E.A., Khakimova, G.R., and Khaindrava, V.G., J. Neurol. Sci., 2014, vol. 340, pp. 198–207.

    Article  CAS  PubMed  Google Scholar 

  13. Calabresi, P., Picconi, B., Tozzi, A., and Filippo, M.D., Trends Neurosci., 2007, vol. 5, pp. 211–219.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia

    E. R. Mingazov & M. V. Ugrumov

Authors
  1. E. R. Mingazov
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  2. M. V. Ugrumov
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Correspondence to E. R. Mingazov.

Additional information

Original Russian Text © E.R. Mingazov, M.V. Ugrumov, 2016, published in Doklady Akademii Nauk, 2016, Vol. 470, No. 1, pp. 99–101.

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Mingazov, E.R., Ugrumov, M.V. Gene expression of proteins of the vesicle cycle in the striatum and motor cortex under functional failure of nigrostriatal system. Dokl Biochem Biophys 470, 313–315 (2016). https://doi.org/10.1134/S160767291605001X

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  • DOI: https://doi.org/10.1134/S160767291605001X

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