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mRNA expression profile of mouse oligodendrocytes in inflammatory conditions

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

In this study, we performed transcriptome profiling of oligodendrocyte culture of mice treated with the remyelinating therapeutic agent benztropine in the presence and absence of interferon gamma (IFNγ). The results of this work are important for understanding the expression profile of oligodendrocytes under conditions of systemic inflammation in the central nervous system in multiple sclerosis as well as the mechanisms of cellular response to benztropine in light of its possible use for the treatment of multiple sclerosis.

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    A. A. Kudriaeva, E. S. Kuzina, E. A. Surina, V. D. Knorre, A. A. Belogurov Jr. & A. G. Gabibov

  2. BioKlinikum Scientific-Technical Center LLC, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088, Russia

    N. A. Khaustova, D. V. Maltseva & A. G. Tonevitsky

  3. Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, ul. Karla Marksa 74, Kazan, Tatarstan, 420055, Russia

    I. S. Glagoleva, A. A. Belogurov Jr. & A. G. Gabibov

  4. Faculty of Chemistry, Moscow State University, Moscow, 119991, Russia

    A. G. Gabibov

Authors
  1. A. A. Kudriaeva
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  2. N. A. Khaustova
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  3. D. V. Maltseva
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  4. E. S. Kuzina
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  5. I. S. Glagoleva
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  6. E. A. Surina
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  7. V. D. Knorre
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  8. A. A. Belogurov Jr.
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  9. A. G. Tonevitsky
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  10. A. G. Gabibov
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Corresponding author

Correspondence to V. D. Knorre.

Additional information

Original Russian Text © A.A. Kudriaeva, N.A. Khaustova, D.V. Maltseva, E.S. Kuzina, I.S. Glagoleva, E.A. Surina, V.D. Knorre, A.A. Belogurov Jr., A.G. Tonevitsky, A.G. Gabibov, 2016, published in Doklady Akademii Nauk, 2016, Vol. 469, No. 3, pp. 361–365.

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Kudriaeva, A.A., Khaustova, N.A., Maltseva, D.V. et al. mRNA expression profile of mouse oligodendrocytes in inflammatory conditions. Dokl Biochem Biophys 469, 264–268 (2016). https://doi.org/10.1134/S1607672916040086

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  • DOI: https://doi.org/10.1134/S1607672916040086

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