Doklady Biochemistry and Biophysics

, Volume 468, Issue 1, pp 203–205 | Cite as

Expression of human selenoprotein genes selh, selk, selm, sels, selv, and gpx-6 in various tumor cell lines

  • E. G. Varlamova
  • M. V. Goltyaev
  • E. E. Fesenko
Biochemistry, Biophysics and Molecular Biology

Abstract

The expression level of the genes encoding six selenocysteine-containing human proteins was determined in the brain, cervical, liver, breast, prostate, and human fibrosarcoma cancer cells. It was found that a high level of expression in all studied types genes of tumor cells is characteristic for selh, selk, and selm genes, encoding SelH, SelK, and SelM proteins, respectively, whereas a complete lack of such expression was shown for gpx-6, selv, and sels genes. The results of this work can be regarded as a major prerequisite for further studies on the role of the three selenoproteins SelH, SelK, and SelM in the regulation of carcinogenesis processes associated with these types of cancer.

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • E. G. Varlamova
    • 1
  • M. V. Goltyaev
    • 1
  • E. E. Fesenko
    • 1
  1. 1.Institute of Cell BiophysicsRussian Academy of SciencesPushchino, Moscow oblastRussia

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