Doklady Biochemistry and Biophysics

, Volume 466, Issue 1, pp 9–12 | Cite as

Recombinant 1F9 spidroin microgels for murine full-thickness wound repairing

  • M. M. Moisenovich
  • N. V. Malyuchenko
  • A. Yu. Arkhipova
  • A. V. Goncharenko
  • M. S. Kotlyarova
  • L. I. Davydova
  • T. V. Vasil’eva
  • V. G. Bogush
  • I. I. Agapov
  • V. G. Debabov
  • M. P. Kirpichnikov
Biochemistry, Biophysics and Molecular Biology

Abstract

The study of the stimulating effect of the microgels (MGs) based on recombinant 1F9 spidroin on the regeneration of the deep skin wound in mice was carried out. The use of spidroin MGs was shown to increase significantly the quality of healing compared to the control. The introduction of the MG in the wound edges led to recovery of all the structural elements of the skin: the epidermis, the dermis, including vascular and nervous network, in the periphery of the wound underlying muscles, and skin appendages (sebaceous and sweat glands and hair follicles) was revealed.

Keywords

Hair Follicle DOKLADY Biochemistry Skin Appendage Full Thickness Wound Wind Edge 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • M. M. Moisenovich
    • 1
  • N. V. Malyuchenko
    • 1
  • A. Yu. Arkhipova
    • 1
  • A. V. Goncharenko
    • 1
  • M. S. Kotlyarova
    • 1
  • L. I. Davydova
    • 2
  • T. V. Vasil’eva
    • 1
  • V. G. Bogush
    • 2
  • I. I. Agapov
    • 3
  • V. G. Debabov
    • 2
  • M. P. Kirpichnikov
    • 1
  1. 1.Department of Biotechnology, Faculty of BiologyMoscow State UniversityMoscowRussia
  2. 2.State Research Institute for Genetics and Selection of Industrial MicroorganismsMoscowRussia
  3. 3.Shumakov Research Institute of Transplantation and Artificial OrgansRussian Ministry of HealthMoscowRussia

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