Doklady Biochemistry and Biophysics

, Volume 465, Issue 1, pp 436–439 | Cite as

Penetration of thyroliberin in the blood and brain regions at intranasal or intravenous administration

  • K. V. Shevchenko
  • T. V. Vyunova
  • A. S. Radilov
  • L. A. Andreeva
  • I. Yu. Nagaev
  • V. P. Shevchenko
  • V. R. Rembovsky
  • N. F. Myasoedov
Biochemistry, Biophysics and Molecular Biology

Abstract

The maximum amounts of the thyroliberin in the blood and brain of rats at intranasal and intravenous administration were determined. It is found that rat hippocampal, cortical, and cerebellar membranes contain two types of specific binding sites (high- and low-affinity) for the labeled ligand. It was shown that, at intranasal and intravenous administration, maximum amounts of the thyroliberin were detected in the cerebellum and then in the cortex and hippocampus. The degradation of the thyroliberin in the rat brain and its regions at intranasal and intravenous administration was studied. It is shown that the degree of degradation and the formation of proteolytic products of the thyroliberin is different in different regions of the rat brain.

Keywords

Tritium Intranasal Administration DOKLADY Biochemistry Proteolytic Product Prolyl Endopeptidase 

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • K. V. Shevchenko
    • 1
  • T. V. Vyunova
    • 1
  • A. S. Radilov
    • 2
  • L. A. Andreeva
    • 1
  • I. Yu. Nagaev
    • 1
  • V. P. Shevchenko
    • 1
  • V. R. Rembovsky
    • 2
  • N. F. Myasoedov
    • 1
  1. 1.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia
  2. 2.Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological AgencyMinistry of Public Health of the Russian FederationLeningrad oblastRussia

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