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Nonconventional three-finger toxin BMLCL from krait Bungarus multicinctus venom with high affinity interacts with nicotinic acetylcholine receptors

  • Biochemistry, Biophysics and Molecular Biology
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Abstract

Nonconventional three-finger toxin BMLCL was isolated from B. multicinctus venom, and its interaction with different subtypes of nicotinic acetylcholine receptor (nAChR) was studied. It was found that BMLCL is able to interact with high efficiency with both α7 and muscle type nAChRs.

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    Yu. N. Utkin, I. E. Kasheverov, D. S. Kudryavtsev, T. V. Andreeva, V. G. Starkov, R. H. Ziganshin & V. I. Tsetlin

  2. Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam

    Hoang Ngoc Anh, Nguyen Thi Thanh Thao & Nguyen Cuu Khoa

  3. The National University of Science and Technology MISiS, Moscow, Russia

    Yu. N. Utkin & D. V. Kuznetsov

  4. Syneuro Ltd., Moscow, Russia

    I. E. Kasheverov & D. S. Kudryavtsev

Authors
  1. Yu. N. Utkin
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  2. I. E. Kasheverov
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  3. D. S. Kudryavtsev
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  4. T. V. Andreeva
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  5. V. G. Starkov
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  6. R. H. Ziganshin
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  7. D. V. Kuznetsov
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  8. Hoang Ngoc Anh
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  9. Nguyen Thi Thanh Thao
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  10. Nguyen Cuu Khoa
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  11. V. I. Tsetlin
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Corresponding author

Correspondence to Yu. N. Utkin.

Additional information

Original Russian Text © Yu.N. Utkin, I.E. Kasheverov, D.S. Kudryavtsev, T.V. Andreeva, V.G. Starkov, R.H. Ziganshin, D.V. Kuznetsov, Hoang Ngoc Anh, Nguyen Thi Thanh Thao, Nguyen Cuu Khoa, V.I. Tsetlin, 2015, published in Doklady Akademii Nauk, 2015, Vol. 464, No. 3, pp. 365–368.

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Utkin, Y.N., Kasheverov, I.E., Kudryavtsev, D.S. et al. Nonconventional three-finger toxin BMLCL from krait Bungarus multicinctus venom with high affinity interacts with nicotinic acetylcholine receptors. Dokl Biochem Biophys 464, 294–297 (2015). https://doi.org/10.1134/S1607672915050099

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  • DOI: https://doi.org/10.1134/S1607672915050099

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