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Doklady Biochemistry and Biophysics

, Volume 464, Issue 1, pp 294–297 | Cite as

Nonconventional three-finger toxin BMLCL from krait Bungarus multicinctus venom with high affinity interacts with nicotinic acetylcholine receptors

  • Yu. N. Utkin
  • I. E. Kasheverov
  • D. S. Kudryavtsev
  • T. V. Andreeva
  • V. G. Starkov
  • R. H. Ziganshin
  • D. V. Kuznetsov
  • Hoang Ngoc Anh
  • Nguyen Thi Thanh Thao
  • Nguyen Cuu Khoa
  • V. I. Tsetlin
Biochemistry, Biophysics and Molecular Biology

Abstract

Nonconventional three-finger toxin BMLCL was isolated from B. multicinctus venom, and its interaction with different subtypes of nicotinic acetylcholine receptor (nAChR) was studied. It was found that BMLCL is able to interact with high efficiency with both α7 and muscle type nAChRs.

Keywords

DOKLADY Biochemistry Kunitz Type Proteinase Inhibitor Quinuclidinyl Benzilate GH4C1 Cell Acetylcholine Binding Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • Yu. N. Utkin
    • 1
    • 3
  • I. E. Kasheverov
    • 1
    • 4
  • D. S. Kudryavtsev
    • 1
    • 4
  • T. V. Andreeva
    • 1
  • V. G. Starkov
    • 1
  • R. H. Ziganshin
    • 1
  • D. V. Kuznetsov
    • 3
  • Hoang Ngoc Anh
    • 2
  • Nguyen Thi Thanh Thao
    • 2
  • Nguyen Cuu Khoa
    • 2
  • V. I. Tsetlin
    • 1
  1. 1.Shemyakin–Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussia
  2. 2.Institute of Applied Materials ScienceVietnam Academy of Science and TechnologyHo Chi Minh CityVietnam
  3. 3.The National University of Science and Technology MISiSMoscowRussia
  4. 4.Syneuro Ltd.MoscowRussia

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