Doklady Biochemistry and Biophysics

, Volume 463, Issue 1, pp 225–228 | Cite as

The immunization with peptide 189–205, a derivative of serotonin receptor subtypes 1B, changes the sensetivity of adenylyl cyclase to hormones in the rat brain

  • K. V. Derkach
  • E. A. Shpakova
  • I. I. Tarasenko
  • O. A. Zharova
  • A. O. Shpakov
Biochemistry, Biophysics and Molecular Biology


The aim of this work was to study the effect of multiple (during 12 months) immunization of rats with BSA-conjugated peptide 189–205 corresponding to the second extracellular loop of rat HT1BR on ACSS activity in the brain of immunized animals (group HT1BR) and its regulation by hormones.


Forskolin Adenylyl Cyclase DOKLADY Biochemistry Adenylyl Cyclase Activity Synaptosomal Membrane 
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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • K. V. Derkach
    • 1
  • E. A. Shpakova
    • 1
  • I. I. Tarasenko
    • 1
  • O. A. Zharova
    • 1
  • A. O. Shpakov
    • 1
  1. 1.Sechenov Institute of Evolutionary Physiology and BiochemistryRussian Academy of SciencesSt. PetersburgRussia

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