Amphiphilic Linear-Branched Copolylactides and Disperse Systems on Their Basis
The linear-branched copolylactides containing linear side poly(ethylene oxide) blocks are synthesized and characterized. The critical micelle concentrations and the aggregative stability and the dispersity of oil/water emulsions stabilized by these copolymers are estimated. The polylactide microparticles are obtained by emulsification followed by evaporation of an organic solvent using acetylsalicylic acid as a model drug. The structure of copolylactides strongly affects the properties of the microparticles. On one hand, the presence of large poly(ethylene oxide) blocks in the linear-branched macromolecules leads to the formation of colloidal systems with a higher aggregative stability of emulsions and a lower size of particles, and on the other hand, the microparticles formed from these copolymers possess a lower incorporation efficiency relative to water-soluble low-molecular-mass compounds and the profile of the release of these compounds is nonlinear and contains the region of accelerated release.
Unable to display preview. Download preview PDF.
- 14.Purification of Laboratory Chemicals, Ed. by W. L. E. Armarego and D. D. Perrin (Buttleworth- Heinemann, Berlin, 1998).Google Scholar
- 16.W. C. Griffin, J. Soc. Cosmet. Chem. 5 (4), 249 (1954).Google Scholar
- 19.Yu. I. Veitser and D. M. Mints, High-molecular Flocculants at Purifying of Water and Sewage (Stroiizdat, Moscow, 1984) [in Russian].Google Scholar