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Polymer Science, Series B

, Volume 59, Issue 6, pp 730–736 | Cite as

Amphiphilic Linear-Branched Copolylactides and Disperse Systems on Their Basis

  • V. V. Istratov
  • V. I. Gomzyak
  • T. V. Krupina
  • V. A. Vasnev
  • S. N. Chvalun
Functional Polymers

Abstract

The linear-branched copolylactides containing linear side poly(ethylene oxide) blocks are synthesized and characterized. The critical micelle concentrations and the aggregative stability and the dispersity of oil/water emulsions stabilized by these copolymers are estimated. The polylactide microparticles are obtained by emulsification followed by evaporation of an organic solvent using acetylsalicylic acid as a model drug. The structure of copolylactides strongly affects the properties of the microparticles. On one hand, the presence of large poly(ethylene oxide) blocks in the linear-branched macromolecules leads to the formation of colloidal systems with a higher aggregative stability of emulsions and a lower size of particles, and on the other hand, the microparticles formed from these copolymers possess a lower incorporation efficiency relative to water-soluble low-molecular-mass compounds and the profile of the release of these compounds is nonlinear and contains the region of accelerated release.

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • V. V. Istratov
    • 1
  • V. I. Gomzyak
    • 2
  • T. V. Krupina
    • 1
  • V. A. Vasnev
    • 1
  • S. N. Chvalun
    • 2
  1. 1.Nesmeyanov Institute of Organoelement CompoundsRussian Academy of SciencesMoscowRussia
  2. 2.Moscow Technological UniversityMoscowRussia

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