Abstract
The linear-branched copolylactides containing linear side poly(ethylene oxide) blocks are synthesized and characterized. The critical micelle concentrations and the aggregative stability and the dispersity of oil/water emulsions stabilized by these copolymers are estimated. The polylactide microparticles are obtained by emulsification followed by evaporation of an organic solvent using acetylsalicylic acid as a model drug. The structure of copolylactides strongly affects the properties of the microparticles. On one hand, the presence of large poly(ethylene oxide) blocks in the linear-branched macromolecules leads to the formation of colloidal systems with a higher aggregative stability of emulsions and a lower size of particles, and on the other hand, the microparticles formed from these copolymers possess a lower incorporation efficiency relative to water-soluble low-molecular-mass compounds and the profile of the release of these compounds is nonlinear and contains the region of accelerated release.
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Original Russian Text © V.V. Istratov, V.I. Gomzyak, T.V. Krupina, V.A. Vasnev, S.N. Chvalun, 2017, published in Vysokomolekulyarnye Soedineniya, Seriya B, 2017, Vol. 59, No. 6, pp. 474–480.
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Istratov, V.V., Gomzyak, V.I., Krupina, T.V. et al. Amphiphilic Linear-Branched Copolylactides and Disperse Systems on Their Basis. Polym. Sci. Ser. B 59, 730–736 (2017). https://doi.org/10.1134/S156009041706001X
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DOI: https://doi.org/10.1134/S156009041706001X