Polymer Science Series B

, Volume 57, Issue 5, pp 530–537 | Cite as

Preparation and characterization of pentapeptide-grafted poly(D,L-lactide)/nanohydroxyapatite/poly(D,L-lactide) composite membrane

Polymer Membranes


A kind of novel bioinspired polymeric material based on poly(D,L-lactic acid) was prepared. Firstly, the maleic anhydride (MA) grafted to PDLLA (PDLLA-g-MA) was synthesized, then PDLLA-g-MA reacted with Gly-Arg-Gly-Asp-Tyr (GRGDY) pentapeptide, which can give the biocompatibility and bioactivity to polymer. Then nano-hydroxyapatite (HAP) was added to enhance the hydrophilicity and cell adhesion of composite obtained. According to spectroscopy (FTIR, 13C NMR) and pyrolysis-gas chromatography-mass spectrometry, PDLLA-g-MA and PDLLA-g-MA-g-GRGDY were synthesized successfully. Static water contact angle test, thermogravimetry, methylthiazolyl tetrazolium assay and scanning electron microscopy were used to characterize the properties of materials. The results show that the new composite material had better hydrophilicity and cell affinity than pure PDLLA, so it can be used as a potential composite membrane for tissue engineering application.


Polylactic Acid Polymer Science Series Composite Membrane Maleic Anhydride Maleic Anhydride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  1. 1.State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of TechnologyWuhanChina

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