Polymer Science Series B

, Volume 57, Issue 5, pp 530–537 | Cite as

Preparation and characterization of pentapeptide-grafted poly(D,L-lactide)/nanohydroxyapatite/poly(D,L-lactide) composite membrane

Polymer Membranes
  • 83 Downloads

Abstract

A kind of novel bioinspired polymeric material based on poly(D,L-lactic acid) was prepared. Firstly, the maleic anhydride (MA) grafted to PDLLA (PDLLA-g-MA) was synthesized, then PDLLA-g-MA reacted with Gly-Arg-Gly-Asp-Tyr (GRGDY) pentapeptide, which can give the biocompatibility and bioactivity to polymer. Then nano-hydroxyapatite (HAP) was added to enhance the hydrophilicity and cell adhesion of composite obtained. According to spectroscopy (FTIR, 13C NMR) and pyrolysis-gas chromatography-mass spectrometry, PDLLA-g-MA and PDLLA-g-MA-g-GRGDY were synthesized successfully. Static water contact angle test, thermogravimetry, methylthiazolyl tetrazolium assay and scanning electron microscopy were used to characterize the properties of materials. The results show that the new composite material had better hydrophilicity and cell affinity than pure PDLLA, so it can be used as a potential composite membrane for tissue engineering application.

Keywords

Polylactic Acid Polymer Science Series Composite Membrane Maleic Anhydride Maleic Anhydride 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    D. Muenprasat, S. Suttireungwong, and C. Tongpin, JOM-J. Min. Met. Mat. S. 20, 189 (2010).Google Scholar
  2. 2.
    N. Prempeh, J. L. Li, D. G. Liu, et al., Pol. Sci., Ser. A 56, 856 (2014).CrossRefGoogle Scholar
  3. 3.
    K. Hamad, M. Kaseem, Y. G. Ko, and F. Deri, Pol. Sci., Ser. A 56, 812 (2014).CrossRefGoogle Scholar
  4. 4.
    B. Śengüland and N. Dilsiz, Pol. Sci., Ser. A 56, 896 (2014).CrossRefGoogle Scholar
  5. 5.
    R. Wen, H. Y. Li, S. Y. Du, et al., J. Biomater. Sci. Pol. Ed. 25, 923 (2014).CrossRefGoogle Scholar
  6. 6.
    C. Deng, H. Y. Tian, P. B. Zhang, et al., Biomacromolecules 7, 590 (2006).CrossRefGoogle Scholar
  7. 7.
    P. Gentile, V. Chiono, I. Carmagnola, and P. V. Hatton, Int. J. Mol. Sci. 15, 3640 (2014).CrossRefGoogle Scholar
  8. 8.
    X. F. Niu, F. Tian, L. Z. Wang, et al., Chin. J. Pol. Sci. 32, 43 (2014).CrossRefGoogle Scholar
  9. 9.
    N. L. García, M. Lamanna, N. D’Accorso, et al., Pol. Degrad. Stab. 97, 2021 (2012).CrossRefGoogle Scholar
  10. 10.
    V. H. Orozco, J. Palacio, J. Sierra, and B. L. López, Coll. Pol. Sci. 291, 2775 (2013).CrossRefGoogle Scholar
  11. 11.
    Z. L. He, Q. Wang, Y. Sun, et al., J. Biomater. Sci. Pol. Ed. 25, 943 (2014).CrossRefGoogle Scholar
  12. 12.
    L. Y. Zhao and G. X. Zhai, J. Control. Release 172, e102 (2013).CrossRefGoogle Scholar
  13. 13.
    J. Xu, J. H. Zhao, Y. Liu, et al., Int. J. Nanomed. 7, 211 (2012).CrossRefGoogle Scholar
  14. 14.
    S. W. Hwang, S. B. Lee, C. K. Lee, et al., Pol. Test. 31, 333 (2012).CrossRefGoogle Scholar
  15. 15.
    P. B. Zhang, H. T. Wu, H. Wu, et al., Biomacromolecules 12, 2667 (2011).CrossRefGoogle Scholar
  16. 16.
    X. H. Wang, S. Shi, G. Guo, et al., J. Biomater. Sci. 22, 1917 (2011).CrossRefGoogle Scholar
  17. 17.
    Y. F. Wang, Y. H. Yan, W. Ren, et al., Trans. Nonferr. Met. Soc. China 1, 29 (2004).Google Scholar
  18. 18.
    T. Wan, S. P. Li, W. J. Zhou, et al., Bio-Med. Mater. Eng. 15, 333 (2005).Google Scholar
  19. 19.
    J. C. Wei, A. Liu, L. Chen, et al., Macromol. Biosci. 9, 631 (2009).CrossRefGoogle Scholar
  20. 20.
    C. S. Wu, Polym. Degrad. Stab. 80, 127 (2003).CrossRefGoogle Scholar
  21. 21.
    C. S. Wu, Polym. Degrad. Stab. 94, 1076 (2009).CrossRefGoogle Scholar
  22. 22.
    R. Mani, M. Bhattacharya, and J. Tang, J. Pol. Sci., Part A 37, 1693 (1999).CrossRefGoogle Scholar
  23. 23.
    D. A. Barrera, E. Zylstra, P. T. Lansbury, and R. Langer, J. Am. Chem. Soc. 115, 11010 (1993).CrossRefGoogle Scholar
  24. 24.
    Y. Hirano, M. Okuno, T. Hayashi, et al., J. Biomater. Sci. Pol. Ed. 4, 235 (1993).CrossRefGoogle Scholar
  25. 25.
    J. I. Rosales-Leal, M. A. Rodríguez-Valverde, G. Mazzaglia, et al., Coll. Surf., Ser. A 365, 222 (2010).CrossRefGoogle Scholar
  26. 26.
    Z. L. Tang, Y. Akiyama, and T. Okano, Polymer 4, 1478 (2012).CrossRefGoogle Scholar
  27. 27.
    A. Higuchi, Q. D. Ling, S. S. Kumar, et al., Prog. Pol. Sci. 39, 1348 (2014).CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  1. 1.State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of TechnologyWuhanChina

Personalised recommendations