Abstract
Poly(γ-benzyl L-glutamate)- g-poly(ethylene glycol) (PBLG-g- PEG) with different grafting ratio was prepared using P-toluenesulfonic acid as catalyst. The effect of the molecular weight of mono- methyl oligo(ethylene glycol), the molar feed ratio and reaction time on the grafting ratio was investigated. The micelles of PBLG-g-PEG were prepared by the dialysis method in deionized water. Transmission electron microscopy and dynamic light scatter studies showed that the micelles exhibited spherical morphologies and the diameter of the micelles was in the range of 50–200 nm. Clonazepam was loaded onto the core part of the micelles and drug-loading content and rele ase rate were dependent on the grafting ratio.
Similar content being viewed by others
Reference
V. I. Lozinsky, I. A. Simenel, M. G. Semenova, and L. E. Belyakova, Polymer Science, Ser. A 48, 435 (2006).
D. Tang, J. Lin, S. Lin, et al., Macromol. Rapid Com-;mun. 25, 1241 (2004).
C. Allen, D. Maysinger, and A. Eisenberg, Colloids Surf., B 16, 3 (1999).
M. Moffitt and A. Eisenberg, Macromolecules 30, 4363 (1997).
A. Rosler, G. W. M. Vandermeulen, and H.-A. Klok, Adv. Drug Delivery Rev. 53, 95 (2001).
H. Zhao, E. P. Douglas, B. S. Harrison, and K. S. Schanze, Langmuir 17, 8428 (2001).
C. S. Cho, J. B. Cheon, Y. I. Jeong, et al., Macromol. Rapid Commun. 18, 361 (1997).
Y. I. Jeong, J. W. Nah, H. C. Lee, et al., Int. J. Pharm. 188, 49 (1999).
A. Lavasanifar, J. Samuel, and G. S. Kwon, Adv. Drug Delivery Rev. 54, 169 (2002).
P. Markland, C. L. Amidon, and V. C. Yang, Int. J. Pharm. 178, 183 (1999).
J.-W. Nah, Y.-I. Jeong, and C.-S. Cho, J. Polym. Sci., Part B: Polym. Phys. 36, 415 (1998).
J.-W. Nah, Y.-I. Jeong, C.-S. Cho, and S. I. Kim, J. Appl. Polym. Sci. 75, 1115 (2000).
I. Oh, K. Lee, H.-Y. Kwon, et al., Int. J. Pharm. 181, 107 (1999).
M. Bae, S. Cho, J. Song, et al., Drug. Exp. Clin. Res. 29, 15 (2003).
Y.-I. Jeong, J.-B. Cheon, S.-H. Kim, et al., J. Controlled Release 51, 169 (1998).
T. Li, J. Lin, T. Chen, and S. Zhang, Polymer 47, 4485 (2006).
I. Oh, K. Lee, H. Y. Kwon, et al., Int. J. Pharm. 181, 107 (1999).
K. Inomata, Y. Sasaki, and T. Nose, J. Polym. Sci., Part B: Polym. Phys. 40, 1904 (2002).
G. Floudas, P. Papadopoulos, H. A. Klok, et al., Macromolecules 36, 3673 (2003).
W. H. Daly and D. Poche, Tetrahedron Lett., 5859 (1988).
K. Inomata, N. Ohara, H. Shimizu, and T. Nose, Polymer 39, 3379 (1998).
K. Inomata, H. Shimizu, and T. Nose, J. Polym. Sci., Part B: Polym. Phys. 38, 1331 (2000).
J. Lin, S. Zhang, T. Chen, et al., J. Biomed. Mater. Res., B 76, 432 (2006).
Author information
Authors and Affiliations
Corresponding author
Additional information
The article is published in the original.
Rights and permissions
About this article
Cite this article
Yi, J., Zhou, X., Hu, G. et al. Preparation of the amphiphilic copolymer of poly(γ-benzyl L-glutamate)-g-poly(ethylene glycol) with different grafting ratio. Polym. Sci. Ser. B 52, 35–40 (2010). https://doi.org/10.1134/S1560090410010057
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1560090410010057