A Convenient One-Pot Synthesis of Chalcones and Their Derivatives and Their Antimicrobial Activity


A series of chalcones were synthesized by base-catalyzed Clasien-Schmidt condensation of substituted benzaldehydes and substituted acetophenones at room temperature. The addition of hydrazine hydrate and hydroxylamine hydrochloride across the double bond of the obtained chalcones gave pyrazole and isoxazole derivatives, respectively. All the synthesized compounds were characterized by 1H and 13C NMR and FT-IR spectroscopy and screened for their in vitro antimicrobial activity against two bacterial strains, Pseudomonas aeruginosa and Pseudomonas oryzihabitans using Ciprofloxacin as standard drug. 1-(2-Methoxyphenyl)-3-phenylprop-2-en-1-one and 1-(4-chlorophenyl)-3-phenylprop-2-en-1-one showed significant activity against both bacterial strains and hence proved to be potent antimicrobial agents.

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Correspondence to D. Utreja.

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Salotra, R., Utreja, D. & Sharma, P. A Convenient One-Pot Synthesis of Chalcones and Their Derivatives and Their Antimicrobial Activity. Russ J Org Chem 56, 2207–2211 (2020). https://doi.org/10.1134/S1070428020120258

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  • chalcones
  • Clasien–Schmidt condensation
  • antimicrobial activity
  • Pseudomonas aeruginosa
  • Pseudomonas oryzihabitans