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Synthesis of 4,4′-Oxydibenzoic Acid Amides and Sulfonamides Containing 2-Arylaminopyrimidine Moieties

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Abstract

New 4,4′-oxydibenzamides and sulfamoyl derivatives of 4,4′-oxydibenzoic acid containing pharmacophoric 2-arylaminopyrimidine fragments in the amide moiety have been synthesized. Acylation of amines of the pyrimidine series with 2-chlorosulfonyl-substituted 4,4′-oxydibenzoic acid gave the corresponding sulfonamides. Arylaminopyrimidine derivatives of 4,4′-oxydibenzamide were obtained in 75–87% yield by acylation of 3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}anilines with 4,4′-oxydibenzoyl chloride. The reactivity of 4,4′-oxydibenzoyl chloride toward amines is discussed.

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Authors and Affiliations

  1. Institute of New Materials Chemistry, National Academy of Sciences of Belarus, 220141, Minsk, Belarus

    Zh. V. Ignatovich, A. L. Ermolinskaya, V. G. Petushok & E. V. Koroleva

  2. Belarusian State Technological University, 220006, Minsk, Belarus

    Ya. M. Katok

Authors
  1. Zh. V. Ignatovich
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  2. A. L. Ermolinskaya
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  3. V. G. Petushok
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  4. Ya. M. Katok
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  5. E. V. Koroleva
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Correspondence to E. V. Koroleva.

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Ignatovich, Z.V., Ermolinskaya, A.L., Petushok, V.G. et al. Synthesis of 4,4′-Oxydibenzoic Acid Amides and Sulfonamides Containing 2-Arylaminopyrimidine Moieties. Russ J Org Chem 56, 2092–2097 (2020). https://doi.org/10.1134/S1070428020120076

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  • DOI: https://doi.org/10.1134/S1070428020120076

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