Synthesis and Anticancer Activity of (E)-5-[(1-Aryl-1H-1,2,3-triazol-4-yl)methylene]thiazolidine-2,4-diones

Abstract

A novel series of 1,2,3-triazolylthiazolidinedione analogs have been synthesized by the condensation of the corresponding 1-aryl-1H-1,2,3-triazole-4-carbaldehydes with thiazolidine-2,4-dione in the presence of KOH. The title compounds were evaluated for their in vitro anticancer activity using MTT assay against four cancer cell lines: A549 (lung), HT-29 (colon), MCF-7 (breast), and A375 (melanoma). Most compounds displayed good anticancer activity, but hydroxy- and nitro-substituted derivatives showed higher activity than the others.

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Scheme 1.
Fig. 1.

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ACKNOWLEDGMENTS

The authors are grateful to the Department of Science of Humanities, Vignan’s Foundation for Science Technology and Research (VFSTR) University, for providing laboratory facilities.

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Correspondence to V. K. Manikala.

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Manikala, V.K., Rao, V.M. Synthesis and Anticancer Activity of (E)-5-[(1-Aryl-1H-1,2,3-triazol-4-yl)methylene]thiazolidine-2,4-diones. Russ J Org Chem 56, 863–868 (2020). https://doi.org/10.1134/S1070428020050206

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Keywords:

  • thiazolidinediones
  • 1,2,3-triazole
  • anticancer activity
  • molecular docking studies