Synthesis of Novel 1-Pyrazolyl-2,7-naphthyridine Derivatives

Abstract

Novel 3-amino-1-(3,5-dimethyl-1H-pyrazol-1-yl)-2,7-naphthyridines were synthesized on the basis of monohydrazides derived from 2,7-naphthyridines. The cyclization of 3-chloro-1-(3,5-dimethyl-1H-pyrazol-1-yl)-2,7-naphthyridine with hydrazine hydrate gave the tricyclic pyrazolo[3,4-c]-2,7-naphthyridine, which was used to prepare the novel heterocyclic system pyrimido[1',2':1,5]pyrazolo[3,4-c]-2,7-naphthyridine.

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The work was financially supported by the Armenian National Science and Education Fund (ANSEF).

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Correspondence to S. N. Sirakanyan.

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Sirakanyan, S.N., Ghazaryan, S.G., Hakobyan, E.K. et al. Synthesis of Novel 1-Pyrazolyl-2,7-naphthyridine Derivatives. Russ J Org Chem 56, 840–844 (2020). https://doi.org/10.1134/S1070428020050176

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Keywords:

  • pyrazole
  • 2,7-naphthyridines
  • pyrazolo[3,4-c]-2,7-naphthyridine
  • pyrimido[1',2':1,5]pyrazolo[3,4-c]2,7-naphthyridine