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A Convenient Synthesis of N2-Alkylated Guanines

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Abstract

An improved three-step synthesis of N2-alkylated guanines has been developed starting from N2-Boc-protected 2-amino-6-chloropurine which was treated with Boc2O, and the resulting doubly N2,9-protected derivative was subjected to N2-alkylation with alkyl halides, followed by hydrolysis. The advantages of this procedure include short reaction steps, simple operations, and good yields.

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Acknowledgments

The authors thank the Laboratory of Organic Functional Molecules, the Sino-French Institute of ECNU, for supports.

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Authors and Affiliations

  1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

    H. T. Zhu, L. Y. Qin, T. Liu & Y. Luo

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  1. H. T. Zhu
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  2. L. Y. Qin
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  3. T. Liu
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  4. Y. Luo
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Corresponding author

Correspondence to Y. Luo.

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The authors declare no conflict of interests.

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Zhu, H.T., Qin, L.Y., Liu, T. et al. A Convenient Synthesis of N2-Alkylated Guanines. Russ J Org Chem 55, 874–878 (2019). https://doi.org/10.1134/S1070428019060198

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  • DOI: https://doi.org/10.1134/S1070428019060198

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