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Synthesis and Anticonvulsant Activity of Amino Amides and Amino Esters Based on 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-cyclopentane-1-carboxylic Acid

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Abstract

Alkaline hydrolysis of 1-(2,3-dihydro-1,4-benzodioxin-6-yl)cyclopentane-1-carbonitrile gave the corresponding carboxylic acid which was converted to carbonyl chloride, and the latter reacted with N, N-di-alkylalkane-α,ω-diamines and dialkylaminoalkanols to afford new amino amides and amino esters which were isolated as hydrochlorides. Anticonvulsant activity of the synthesized compounds was studied.

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References

  1. Arustamyan, Zh.S., Markaryan, R.E., Agekyan, A.A., Stepanyan, G.M., Paronikyan, R.V, Shirinyan, E.A., Noravyan O.S., and Minasyan, N.S., Khim. Zh. Arm., 2014, vol. 67, p. 92.

    CAS  Google Scholar 

  2. Airapetyan, G.K., Akopyan, M.G., Arustamyan, Zh.S., and Markaryan, E.A., Chem. Heterocycl. Compd., 1993, vol. 29, p. 578. doi https://doi.org/10.1007/BF00534473

    Article  Google Scholar 

  3. Kankanala, J., Marchand, Ch., Abdelmalak, M., Aihara, H., Pommier, Y., and Wang, S., J. Med. Chem., 2016, vol. 59, p. 2734. doi https://doi.org/10.1021/acs.jmedchem.5b01973

    Article  CAS  PubMed  Google Scholar 

  4. Davies, S.G., Fletcher, A.M., Frost, A.B., Kennedi, M.S., Roberts, P.M., and Thomson, J.E., Tetrahedron, 2016, vol. 72, p. 2139. doi https://doi.org/10.1016/j.tet.2016.03.008

    Article  CAS  Google Scholar 

  5. Vogel, H.G. and Vogel, W.H., Drug Discovery and Evaluation: Pharmacological Assays, Vogel, H.G., Ed., Berlin: Springer, 2008, 3rd ed., p. 565.

  6. Belen’kii M.L., Elementy kolichestvennoi otsenki farmakologicheskogo effekta (Elements of Quantitative Evaluation of Pharmacological Effect), Leningrad: Meditsina, 1961.

    Google Scholar 

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Authors and Affiliations

  1. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan, Armenia

    Zh. S. Arustamyan, R. E. Markaryan, A. A. Aghekyan, I. M. Nazaryan, A. G. Hakobyan & R. G. Paronikyan

  2. Molecular Structure Research Center, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan, Armenia

    N. S. Minasyan

Authors
  1. Zh. S. Arustamyan
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  2. R. E. Markaryan
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  3. A. A. Aghekyan
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  4. I. M. Nazaryan
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  5. A. G. Hakobyan
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  6. R. G. Paronikyan
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  7. N. S. Minasyan
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Corresponding author

Correspondence to A. A. Aghekyan.

Additional information

Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 6, pp. 896–900.

Conflict of Interests

The authors declare no conflict of interests.

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Arustamyan, Z.S., Markaryan, R.E., Aghekyan, A.A. et al. Synthesis and Anticonvulsant Activity of Amino Amides and Amino Esters Based on 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-cyclopentane-1-carboxylic Acid. Russ J Org Chem 55, 796–799 (2019). https://doi.org/10.1134/S1070428019060095

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  • DOI: https://doi.org/10.1134/S1070428019060095

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