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Russian Journal of Organic Chemistry

, Volume 55, Issue 5, pp 615–619 | Cite as

A New Synthesis of Calcium N-(5-Hydroxynicotinoyl)-L-glutamate and Its X-ray Diffraction Structure

  • A. V. KiselevEmail author
  • A. A. Machula
  • S. I. EfimovEmail author
  • E. B. Pashkova
  • S. V. Stovbun
Article
  • 11 Downloads

Abstract

A new synthesis of N-(5-hydroxynicotinoyl)-L-glutamic acid via a 5-hydroxynicotinic acid imidazolide intermediate has been developed. Its calcium salt (Ampasse) has been synthesized and its structure was studied by X-ray diffraction analysis. The reaction conditions for all stages of the process have been optimized and a method for the purification of the substance has been improved.

Keywords

Ampasse calcium N-(5-hydroxynicotinoyl)-L-glutamate N-(5-hydroxynicotinoyl)-L-glutamic acid 5-hydroxynicotinic acid diethyl L-glutamate XRD 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Semenov Institute of Chemical PhysicsRussian Academy of SciencesMoscowRussia
  2. 2.BIONAll-Russian Research Institute of Agricultural Radiology and AgroecologyObninsk, Kaluzhskaya obl.Russia

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