Abstract
A new synthesis of N-(5-hydroxynicotinoyl)-L-glutamic acid via a 5-hydroxynicotinic acid imidazolide intermediate has been developed. Its calcium salt (Ampasse) has been synthesized and its structure was studied by X-ray diffraction analysis. The reaction conditions for all stages of the process have been optimized and a method for the purification of the substance has been improved.
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Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 5, pp. 709–713.
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Kiselev, A.V., Machula, A.A., Efimov, S.I. et al. A New Synthesis of Calcium N-(5-Hydroxynicotinoyl)-L-glutamate and Its X-ray Diffraction Structure. Russ J Org Chem 55, 615–619 (2019). https://doi.org/10.1134/S1070428019050063
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DOI: https://doi.org/10.1134/S1070428019050063