Russian Journal of Organic Chemistry

, Volume 55, Issue 5, pp 602–607 | Cite as

Synthesis of Methyl 4-Aryl-4-oxo-2-{4-[(1,3-thiazol-2-yl)-sulfamoyl]phenylamino}but-2-enoates and Their Reactions with Ninhydrin

  • V. L. GeinEmail author
  • O. V. Bobrovskaya
  • A. A. Russkikh
  • M. V. Dmitriev
  • A. N. Yankin


The reaction of methyl aroylpyruvates with 2-(4-aminobenzenesulfonamido)thiazole (norsulfazole) in acetic acid-ethanol (1: 1) afforded methyl (2Z)-4-aryl-4-oxo-2-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl-amino} but-2-enoates which reacted with ninhydrin in glacial acetic acid to give 4-aroyl-3-{4-[(1,3-thiazol-2-yl)-sulfamoyl]phenylamino} spiro[2,5-dihydrofuran-5,2′-indane]-2,1′,3′-triones.


methyl (2Z)-4-aryl-4-oxo-2-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenylamino} but-2-enoates 2-(4-aminobenzenesulfonamido)thiazole (norsulfazole) ninhydrin 4-aroyl-3-{4-[(1,3-thiazol-2-yl)sulfamoyl]-phe-nylamino} spiro[2,5-dihydrofuran-5,2′-indane]-2,1′,3′-triones, synthesis 


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The studies were carried out using the equipment of the resource centers of the Science Park of St. Petersburg State University “Chemistry Educational Center,” “Chemical Analysis and Materials Research Center,” and “Magnetic Resonance Research Centre.”


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • V. L. Gein
    • 1
    Email author
  • O. V. Bobrovskaya
    • 1
  • A. A. Russkikh
    • 1
  • M. V. Dmitriev
    • 2
  • A. N. Yankin
    • 3
  1. 1.Perm State Pharmaceutical AcademyPermRussia
  2. 2.Perm State National Research UniversityPermRussia
  3. 3.St. Petersburg State UniversitySt. PetersburgRussia

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