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Simultaneous Double C2/C3 Functionalization of Quinoline with p-Nitrobenzoyl(phenyl)acetylene. One-Pot Synthesis of 3-(4-Nitrobenzoyl)-2-phenylquinoline

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Abstract

4-Nitrophenyl)(2-phenylquinolin-3-yl)methanone has been synthesized in one step by simultaneous double C2/C3 functionalization of the pyridine ring of quinoline molecule by the action of p-nitrobenzoyl( phenyl)acetylene in aqueous potassium hydroxide.

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Authors and Affiliations

  1. Favorskii Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, ul. Favorskogo 1, Irkutsk, 664033, Russia

    K. V. Belyaeva, L. P. Nikitina, A. V. Afonin & B. A. Trofimov

Authors
  1. K. V. Belyaeva
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  2. L. P. Nikitina
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  3. A. V. Afonin
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  4. B. A. Trofimov
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Corresponding author

Correspondence to B. A. Trofimov.

Additional information

Original Russian Text © K.V. Belyaeva, L.P. Nikitina, A.V. Afonin, B.A. Trofimov, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 12, pp. 1830–1832.

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Belyaeva, K.V., Nikitina, L.P., Afonin, A.V. et al. Simultaneous Double C2/C3 Functionalization of Quinoline with p-Nitrobenzoyl(phenyl)acetylene. One-Pot Synthesis of 3-(4-Nitrobenzoyl)-2-phenylquinoline. Russ J Org Chem 54, 1845–1847 (2018). https://doi.org/10.1134/S1070428018120205

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  • DOI: https://doi.org/10.1134/S1070428018120205

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