Abstract
Three-component condensation of thiourea with equimolar amounts of formaldehyde and morpholine afforded N-(morpholin-4-ylmethyl) derivative, whereas analogous reaction with 2 equiv of formaldehyde and amine gave symmetrical N,N′-bis(morpholin-4-ylmethyl)thiourea. In the condensation of thiourea with piperidine and formaldehyde, only symmetrical N,N′-bis(piperidin-1-ylmethyl)thiourea was isolated, regardless of the reactant ratio.
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14 December 2018
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This study was performed in the framework of the project (no. 10.735.2014/K) and base parts (no. 10.7608.2017/8.9) of state assignment of the Ministry of Education and Science of the Russian Federation in the sphere of research activity.
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Original Russian Text © Yu.A. Martinovich, S.M. Ramsh, F. Hamoud, V.S. Fundamenskii, V.V. Gurzhii, V.I. Zakharov, E.S. Khrabrov, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 6, pp. 876–883.
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Martinovich, Y.A., Ramsh, S.M., Hamoud, F. et al. Aminomethylation of Thiourea with Formaldehyde and Cyclic Amines. Russ J Org Chem 54, 878–885 (2018). https://doi.org/10.1134/S107042801806009X
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DOI: https://doi.org/10.1134/S107042801806009X