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Synthesis of 3-Chloro-4H-imidazo[5,1-c][1,4]benzothiazines and 3-Chloro-4H-5λ6-imidazo[5,1-c][1,4]benzothiazine 5,5-Dioxides

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Abstract

Intramolecular cyclization of S-BBBBB[1-(2-bromoaryl)-4-chloro-1H-imidazol-5-yl]methylBBBBB ethanethioates on heating in DMF in the presence of K2CO3 afforded 3-chloro-4H-imidazo[5,1-c][1,4]benzothiazines which were oxidized with hydrogen peroxide to the corresponding S,S-dioxides.

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Authors and Affiliations

  1. Bukovinian State Medical University, Teatral’naya pl. 2, Chernovtsy, 58000, Ukraine

    V. A. Chornous & A. N. Grozav

  2. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 5, Kiev, 02660, Ukraine

    M. V. Vovk

Authors
  1. V. A. Chornous
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  2. A. N. Grozav
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  3. M. V. Vovk
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Corresponding author

Correspondence to A. N. Grozav.

Additional information

Original Russian Text © V.A. Chornous, A.N. Grozav, M.V. Vovk, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 1, pp. 149–151.

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Chornous, V.A., Grozav, A.N. & Vovk, M.V. Synthesis of 3-Chloro-4H-imidazo[5,1-c][1,4]benzothiazines and 3-Chloro-4H-5λ6-imidazo[5,1-c][1,4]benzothiazine 5,5-Dioxides. Russ J Org Chem 54, 151–153 (2018). https://doi.org/10.1134/S1070428018010189

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  • DOI: https://doi.org/10.1134/S1070428018010189

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