Russian Journal of Organic Chemistry

, Volume 53, Issue 5, pp 734–737 | Cite as

One-pot synthesis of alkyl 3-aryl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoates

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Abstract

Reaction of 3-aryl-2-bromopropanoic acids esters, products of the Meerwein arylation, with sodium azide afforded alkyl 2-azido-3-arylpropanoates. The latter react with ethyl acetoacetate and phenylacetylene to form 1,2,3-triazole derivatives. A one-pot method for the synthesis of 3-aryl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-propanoic acid esters via a tricomponent reaction of alkyl 2-bromo-3-arylpropanoates, sodium azide, and phenylacetylene in the presence of CuI was developed.

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • N. T. Pokhodylo
    • 1
  • R. D. Savka
    • 1
  • M. D. Obushak
    • 1
  1. 1.Lviv Ivan Franko National UniversityLvivUkraine

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