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One-pot synthesis of alkyl 3-aryl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoates

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Abstract

Reaction of 3-aryl-2-bromopropanoic acids esters, products of the Meerwein arylation, with sodium azide afforded alkyl 2-azido-3-arylpropanoates. The latter react with ethyl acetoacetate and phenylacetylene to form 1,2,3-triazole derivatives. A one-pot method for the synthesis of 3-aryl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-propanoic acid esters via a tricomponent reaction of alkyl 2-bromo-3-arylpropanoates, sodium azide, and phenylacetylene in the presence of CuI was developed.

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Authors and Affiliations

  1. Lviv Ivan Franko National University, ul. Kyryla i Mefodiya 6, Lviv, 79005, Ukraine

    N. T. Pokhodylo, R. D. Savka & M. D. Obushak

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  1. N. T. Pokhodylo
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  2. R. D. Savka
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  3. M. D. Obushak
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Correspondence to M. D. Obushak.

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Original Russian Text © N.T. Pokhodylo, R.D. Savka, M.D. Obushak, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 5, pp. 723–726.

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Pokhodylo, N.T., Savka, R.D. & Obushak, M.D. One-pot synthesis of alkyl 3-aryl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoates. Russ J Org Chem 53, 734–737 (2017). https://doi.org/10.1134/S1070428017050141

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  • DOI: https://doi.org/10.1134/S1070428017050141

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